Patents by Inventor Leichang PAN

Leichang PAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrocyclic kinase inhibitor
    Patent number: 11584759
    Abstract: Disclosed is a macrocyclic kinase inhibitor, wherein the compound, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof is as shown in formula I. Experiments show that the new compound as shown in formula I disclosed in the present invention exhibits an excellent TRK inhibitory activity, has a significant inhibitory effect on TRKA-mutant cell growth, and exhibits an excellent inhibitory effect on in vivo tumor growth, thus providing a new choice for the clinical treatment of diseases associated with abnormal TRK activity.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: February 21, 2023
    Assignee: HITGEN INC.
    Inventors: Jin Li, Dengyou Zhang, Jingchao Feng, Zhi Wang, Leichang Pan, Jing Hu, Wei Chen
  • MACROCYCLIC KINASE INHIBITOR
    Publication number: 20210147443
    Abstract: Disclosed is a macrocyclic kinase inhibitor, wherein the compound, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof is as shown in formula I. Experiments show that the new compound as shown in formula I disclosed in the present invention exhibits an excellent TRK inhibitory activity, has a significant inhibitory effect on TRKA-mutant cell growth, and exhibits an excellent inhibitory effect on in vivo tumor growth, thus providing a new choice for the clinical treatment of diseases associated with abnormal TRK activity.
    Type: Application
    Filed: April 17, 2019
    Publication date: May 20, 2021
    Applicant: HITGEN INC.
    Inventors: Jin LI, Dengyou ZHANG, Jingchao FENG, Zhi WANG, Leichang PAN, Jing HU, Wei CHEN