Patents by Inventor Leif Hilden

Leif Hilden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for manufacturing entacapone
    Patent number: 7932415
    Abstract: New processes for manufacturing entacapone are provided.
    Type: Grant
    Filed: February 6, 2007
    Date of Patent: April 26, 2011
    Assignee: Orion Corporation
    Inventors: Martti Hytönen, Leif Hilden
  • Preparation method for quetiapine
    Patent number: 7858777
    Abstract: The present invention discloses a process for the preparation of quetiapine, which comprises the ring closure and deprotection of a compound of the formula (I), as well as novel intermediates in the process.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: December 28, 2010
    Assignee: Fermion Oy
    Inventors: Leif Hilden, Arne Grumann, Soini Huhta, Petteri Rummakko
  • PROCESS FOR MANUFACTURING ENTACAPONE
    Publication number: 20090012176
    Abstract: Processes for manufacturing entacapone are provided.
    Type: Application
    Filed: February 6, 2007
    Publication date: January 8, 2009
    Inventors: Martti Hytonen, Leif Hilden
  • Preparation method for quetiapine
    Publication number: 20070111986
    Abstract: The present invention discloses a process for the preparation of quetiapine, which comprises the ring closure and deprotection of a compound of the formula (I), as well as novel intermediates in the process.
    Type: Application
    Filed: September 23, 2004
    Publication date: May 17, 2007
    Applicant: FERMION OY
    Inventors: Leif Hilden, Ame Grumann, Soini Huhta, Petteri Rummakko
  • Process for the preparation of 1 - (3-dimethylaminopropyl) -1 - (4-fluorophenyl) -1,3-dihydroisobenzofuran-5-carbonitrile
    Publication number: 20050209467
    Abstract: The present invention is directed to novel processes for the preparation of citalopram comprising halogenation of a phthalide compound of formula II, wherein R is a suitable group to be changed to CN, to afford an acid halogenide compound of formula III wherein R is as defined as above and X is halogen, and thereafter obtaining citalopram through two successive reactions with suitable organometallic halides or organoboranes or by a reaction with organometallic 4-fluorophenylhalide or 4-fluorophenylborane followed by reduction and alkylation, and an exchange of R to cyano to afford citalopram. The order of the reactions can be varied depending for example on the starting compound used.
    Type: Application
    Filed: January 31, 2005
    Publication date: September 22, 2005
    Applicant: Fermion Oy
    Inventors: Leif Hilden, Petteri Rummakko, Arne Grumann, Pekka Pietikaeinen
  • Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
    Patent number: 6753433
    Abstract: Method for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) comprising the reaction of a compound of formula wherein X is a halogen, with organometallic dimethylaminopropyl halide. Other aspects of the invention are new compounds of formula II and formula III and their preparation.
    Type: Grant
    Filed: February 24, 2003
    Date of Patent: June 22, 2004
    Assignee: Orion Corporation, FERMION
    Inventors: Leif Hilden, Tuomas Huuhtanen, Petteri Rummakko, Arne Grumann, Pekka Pietikaeinen
  • Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
    Publication number: 20030130527
    Abstract: Method for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) comprising the reaction of a compound of formula 1
    Type: Application
    Filed: February 24, 2003
    Publication date: July 10, 2003
    Applicant: ORION CORPORATION FERMION
    Inventors: Leif Hilden, Tuomas Huuhtanen, Petteri Rummakko, Arne Grumann, Pekka Pietikaeinen
  • Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
    Patent number: 6579993
    Abstract: Method for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluoro-phenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) comprising the reaction of a compound of formula wherein X is a halogen, with organometallic dimethylaminopropyl halide. Other aspects of the invention are new compounds of formula II and formula III and their preparation.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: June 17, 2003
    Assignee: Orion Corporation, Fermion
    Inventors: Leif Hilden, Tuomas Huuhtanen, Petteri Rummakko, Arne Grumann, Pekka Pietikaeinen
  • Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
    Publication number: 20020115872
    Abstract: Method for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluoro-phenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) comprising the reaction of a compound of formula 1
    Type: Application
    Filed: January 30, 2002
    Publication date: August 22, 2002
    Applicant: ORION CORPORATION FERMION
    Inventors: Leif Hilden, Tuomas Huuhtanen, Petteri Rummakko, Arne Grumann, Pekka Pietikaeinen