Abstract: The present disclosure generally pertains to systems and methods for cancelling crosstalk. A multiple input, multiple output (MIMO) system in accordance with one exemplary embodiment of the present disclosure has a plurality of receivers, which are capable of exchanging information with one another. Each receiver is coupled to a respective subscriber line and receives signals from a remote transmitter. In each path of the MIMO system, in domain crosstalk and possibly some combination of noise, alien crosstalk, and/or other interference such as RF interference, is canceled from the signal being processed. In some cases, a cancellation signal for cancelling crosstalk is based on an output of a symbol decision element, such as a slicer or decoder, thereby improving the accuracy of the cancellation signal.