Abstract: A control circuit can access multi-dimensional information for a particular patient and then automatically determine a supplemental boundary for at least one portion of the particular patient (such as a treatment target comprising a part of the patient's heart and/or one or more organs-at-risk) as a function, at least in part, of the multi-dimensional information. The latter may comprise determining a margin that is added to a boundary of the at least one portion of the particular patient. The control circuit can then, for example, determine a planning treatment volume as a function, at least in part, of that supplemental boundary. These teachings will then permit, for example, optimizing a cardiac radioablation treatment plan for the particular patient as a function of various dimensions of movement as derived, at least in part, from the aforementioned multi-dimensional information.

Abstract: A control circuit can access multi-dimensional information for a particular patient and then automatically determine a supplemental boundary for at least one portion of the particular patient (such as a treatment target and/or one or more organs-at-risk) as a function, at least in part, of the multi-dimensional information. The latter may comprise determining a margin that is added to a boundary of the at least one portion of the particular patient. The control circuit can then, for example, determine a planning treatment volume as a function, at least in part, of that supplemental boundary. These teachings will then permit, for example, optimizing a radiation-based therapeutic treatment plan for the particular patient as a function of various dimensions of movement as derived, at least in part, from the aforementioned multi-dimensional information.

Abstract: Systems and methods for target area recommendation and guidance during radioablation treatment planning are disclosed. In some examples, a computing device receives (702) image data from one or more modalities for a patient. The computing device determines (708) a recommended target area for treatment based on the image data, and determines one or more corresponding segments of a segment model based on the recommended target area. Further, the computing device displays the segment model identifying the determined one or more segments, and receives (710) input data modifying the determined one or more segments. Based on the input data, the computing device updates (716) the one or more segments, and generates target definition data characterizing the updated one or more segments. The computing device transmits the target definition data for treating the patient.

Abstract: Systems (100) and methods (700, 800, 900) for target area recommendation and guidance during radioablation treatment planning are disclosed. In some examples. a computing device (104) receives image data (103) from one or more modalities for a patient. The computing device (104) determines a recommended target area for treatment based on the image data (103), and determines one or more corresponding segments of a segment model based on the recommended target area. Further, the computing device (104) displays the segment model identifying the determined one or more segments. and receives input data modifying the determined one or more segments. Based on the input data, the computing device (104) updates the one or more segments, and generates target definition data characterizing the updated one or more segments. The computing device (104) transmits the target definition data for treating the patient.

Abstract: The present invention includes a method of treating or preventing memory loss in a subject suffering from a memory loss-related disease or aging, comprising, consisting essentially of, or consisting of, administering an effective amount of a serotonin-norepinephrine reuptake inhibitor (SNRI) to the subject, wherein the serotonin-norepinephrine reuptake inhibitor is duloxetine or active derivative thereof, such as a subject with memory complaints as part of the aging process, mild cognitive impairment, Alzheimer's disease or dementia and an elevated depressive endophenotype genotype (DepE).

Abstract: A tote-sled assembly includes spaced runners adapted to slide along malleable and hardened surfaces and having separate parts that are assembled in an end to end relationship and are overlapped by a detachable connector. The tote-sled assembly further includes a plurality of toothed wheels and detachable vertical struts adapted to reduce the overall size of a partially disassembled assembly.

Abstract: A wheeled beach sled kit of separate parts adapted for intermittent assemblage and disasemblage thereof into a sled for pulling paraphanelia alternately on sand and pavements including spaced-apart tubular sled-runners rigidly interconnected by forward and rearward axles each mounting spaced-apart wheels that extend below the bottoms of the sled runners, and a pair of rails uprightly mountable in mounting sled runner holes continuous of the tubular sled runners at opposite ends of each sled runner of the paired sled runners, the pair of rails being spaced-apart and having spaced apart horizontal rail-portions when uprightly mounted, a flexible material formed into an open-top contained suspended downwardly from and between the spaced apart horizontal rail-portions, and shade structure including a pair of spaced apart supports mounted on the pair of rails, with a shade-producing fabric mounted on and extending between the shade structures.