Abstract: The multi-layer multi-material foam mattresses of the present disclosure and related inventions provide novel combinations of multiple layer, multiple material foam layers or stacks which provide unexpected and improved support characteristics and pressure relief and distribution. By combining multiple layers of visco-elastic or latex foam as the top structure of a mattress supported by underlying layers of a laminated urethane foam core, the conformance properties of visco-elastic or latex foam are achieved along with structural support from the underlying core. The multi-layer multi-material foam mattresses of the present disclosure and related inventions include in the various embodiments two or three layers of a first type of foam such as visco-elastic foam or latex foam, in combination with a multi-layer foam support core of a second type of foam such as urethane foam.