Patents by Inventor Leigh Zawel

Leigh Zawel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human fast-1 gene
    Publication number: 20060281078
    Abstract: hFAST-1 is a human forkhead activin signal transducer gene. The hFAST-1 protein has the ability to bind to human Smad2 and activate an activin response element (ARE). The hFAST-1-dependent activation of ARE is dependent on endogenous Smad4 and stimulation of the TGF-? receptor. The hFAST-1 protein binds to a novel DNA motif, TGT(G/T)(T/G)ATT, which is present within the ARE. This motif is important for the activation of genes responsive to ligands of the TGF-? family. The invention includes tools for investigating the TGF-? signaling pathway and screening for compounds which modulate the action of TGF-?.
    Type: Application
    Filed: February 6, 2001
    Publication date: December 14, 2006
    Inventors: Shibin Zhou, Leigh Zawel, Bert Vogelstein, Kenneth Kinzler
  • Peptide inhibitors of smac protein binding to inhibitor of apoptosis proteins (iap)
    Publication number: 20060128632
    Abstract: The present disclosure relates to XIAP inhibitor compounds of the formula I wherein the substituents are as described in the specification. The inventive compounds are useful as therapeutic agents for the treatment of proliferative disorders, including cancer.
    Type: Application
    Filed: July 1, 2003
    Publication date: June 15, 2006
    Inventors: Sushil Sharma, Leigh Zawel, Mark Palermo, Nagarajan Chandeamouli, Kenneth Bair
  • Peptide inhibitors of smac protein binding to inhibitor of apoptosis proteins (IAP)
    Publication number: 20060052311
    Abstract: The present disclosure relates to XIAP inhibitor compounds of the formula I wherein the substituents are as described in the specification. The inventive compounds are useful as therapeutic agents for the treatment of proliferative disorders, including cancer.
    Type: Application
    Filed: August 12, 2005
    Publication date: March 9, 2006
    Inventors: Sushil Sharma, Leigh Zawel, Mark Palermo, Nagarajan Chandramouli, Kenneth Bair
  • Organic compounds
    Publication number: 20050234042
    Abstract: Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I
    Type: Application
    Filed: April 6, 2005
    Publication date: October 20, 2005
    Inventors: Mark Palermo, Sushil Sharma, Christopher Straub, Run-Ming Wang, Leigh Zawel, Yanlin Zhang, Zhuoliang Chen, Yaping Wang, Fan Yang, Wojciech Wrona, Gang Liu, Mark Charest, Feng He
  • Human fast-1 protein
    Patent number: 6225441
    Abstract: hFAST-1 is a human forkhead activin signal transducer gene. The hFAST-1 protein has the ability to bind to human Smad2 and activate an activin response element (ARE). The hFAST-1-dependent activation of ARE is dependent on endogenous Smad4 and stimulation of the TGF-&bgr; receptor. The hFAST-1 protein binds to a novel DNA motif, TGT(G/T)(T/G)ATT, which is present within the ARE. This motif is important for the activation of genes responsive to ligands of the TGF-&bgr; family. The invention includes tools for investigating the TGF-&bgr; signaling pathway and screening for compounds which modulate the action of TGF-&bgr;.
    Type: Grant
    Filed: March 7, 2000
    Date of Patent: May 1, 2001
    Assignee: The Johns Hopkins University
    Inventors: Shibin Zhou, Leigh Zawel, Bert Vogelstein, Kenneth W. Kinzler
  • Human fast-1 gene
    Patent number: 6110738
    Abstract: hFAST-1 is a human forkhead activin signal transducer gene. The hFAST-1 protein has the ability to bind to human Smad2 and activate an activin response element (ARE). The hFAST-1-dependent activation of ARE is dependent on endogenous Smad4 and stimulation of the TGF-.beta. receptor. The hFAST-1 protein binds to a novel DNA motif, TGT(G/T)(T/G)ATT, which is present within the ARE. This motif is important for the activation of genes responsive to ligands of the TGF-.beta. family. The invention includes tools for investigating the TGF-.beta. signaling pathway and screening for compounds which modulate the action of TGF-.beta..
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: August 29, 2000
    Assignee: The Johns Hopkins University
    Inventors: Shibin Zhou, Leigh Zawel, Bert Vogelstein, Kenneth W. Kinzler
  • Human Smad3 and Smad4 are sequence-specific transcription activators
    Patent number: 6100032
    Abstract: Two human Smad proteins (Smad3 and Smad4) specifically recognize an identical 8 bp palindromic sequence (GTCTAGAC) (SEQ ID NO: 1). Tandem repeats of this palindrome confer striking TGF-.beta. responsiveness to a minimal promoter. This responsiveness is abrogated by targeted deletion of the cellular Smad4 gene. DNA molecules comprising the 8 bp palindromic sequence can be used in assays for drug screening and diagnostically.
    Type: Grant
    Filed: March 13, 1998
    Date of Patent: August 8, 2000
    Assignee: Johns Hopkins University
    Inventors: Scott Eliot Kern, Leigh Zawel, Jia Le Dai, Bert Vogelstein, Kenneth W. Kinzler