Abstract: Unsaturated solutions of phenoxazone and/or phenoxazine small molecules, or precursors or derivatives thereof, for example xanthommatin, uses the phenoxazone and/or phenoxazine as standalone discrete molecules in dermatological and skin care formulations to enhance protection and safety. The unaggregated xanthommatin molecules are capable of boosting UV-filtering performance and increasing the photo-stability and UV-absorptive properties of known chemical UV filters. Accordingly, unaggregated xanthommatin in an unsaturated solution can replace the performance of the UV-A filter avobenzone in suncare products and replace the performance of known antioxidants producing more performance stability over time.

Abstract: The present invention provides in vitro models of non-penetrating traumatic brain injury, which include a network of extracellular matrix (ECM) protein fibrils, methods for preparing such models, and uses of such models for, e.g., identifying compounds suitable for preventing or treating non-penetrating traumatic brain injury.

Abstract: The present invention provides synthetic pigment structures, isolated pigment granules, and pigment proteins, as well as methods of making and using them.

Abstract: The present invention is based, at least in part, on the isolation of intact pigment granules from the brown chromatophores in the skin of the cuttlefish, Sepia officinalis and the characterization of the optical properties of the isolated pigment granules. In particular, it has been discovered that the isolated pigment granules not only fluoresce in the far red wavelength of light when excited with blue/green light, but they also absorb and transmit or scatter light in the visible light range and are stable and optically active under ambient conditions.