Abstract: The present disclosure relates to the field of nuclear imaging and therapy, and more specifically to high purity copper radiotracer compositions useful in imaging, such as positron emission tomography (PET) and single-photon emission computerized tomography (SPECT), and therapy. More specifically, the present disclosure relates to novel compositions useful in imaging and treatment of conditions such as prostate cancer, somatostatin receptor-expressing tumors, like neuroendocrine tumor, epithelial tumors, as well as to methods wherein such compositions are prepared.

Abstract: The present disclosure relates to the field of nuclear imaging and therapy, and more specifically to high purity copper radiotracer compositions useful in imaging, such as positron emission tomography (PET) and single-photon emission computerized tomography (SPECT), and therapy. More specifically, the present disclosure relates to novel compositions useful in imaging and treatment of conditions such as prostate cancer, somatostatin receptor-expressing tumors, like neuroendocrine tumor, epithelial tumors, as well as to methods wherein such compositions are prepared.

Abstract: The present disclosure relates to the field of nuclear imaging and therapy, and more specifically to high purity copper radiotracer compositions useful in imaging, such as positron emission tomography (PET) and single-photon emission computerized tomography (SPECT), and therapy. More specifically, the present disclosure relates to novel compositions useful in imaging and treatment of conditions such as prostate cancer, somatostatin receptor-expressing tumors, like neuroendocrine tumor, epithelial tumors, as well as to methods wherein such compositions are prepared.

Abstract: The present disclosure relates to the field of nuclear imaging and therapy, and more specifically to high purity copper radiotracer compositions useful in imaging, such as positron emission tomography (PET) and single-photon emission computerized tomography (SPECT), and therapy. More specifically, the present disclosure relates to novel compositions useful in imaging and treatment of conditions such as prostate cancer, somatostatin receptor-expressing tumors, like neuroendocrine tumor, epithelial tumors, as well as to methods wherein such compositions are prepared.

Abstract: The present disclosure is related to novel solid target systems that produce novel high-purity radionuclide compositions using medical cyclotrons, the compositions are of suitable radionuclidic and chemical purity for use in radiopharmaceutical applications, for example, diagnostic imaging and targeted-radionuclide therapy in nuclear medicine.

Abstract: The present disclosure relates to the field of fibroblast activation protein (FAP) inhibitors, conjugates comprising the novel FAP inhibitors, including radiotracers, for the imaging, diagnosis and treatment of conditions characterized by overexpression of FAP.

Abstract: A radionuclide generation system including a tube system configured to permit insertion and removal of irradiation targets into an instrumentation finger of a nuclear reactor, and an irradiation target drive system configured to insert the irradiation targets into the instrumentation finger and to remove the irradiation targets from the instrumentation finger. The radionuclide generation system further includes an instrumentation and control unit which is linked to an online core monitoring system and being configured to calculate optimal irradiation locations for the irradiation targets based on the actual state of the reactor as provided by the online core monitoring system.

Abstract: A method for harvesting activated irradiation targets from an instrumentation tube system of a nuclear reactor comprises: Coupling the instrumentation tube system to a discharge tube having an apex, exit port and lock element between the apex and exit port; Passing the activated irradiation targets from the instrumentation tube system into the discharge tube and blocking movement of said targets out of the discharge tube using the lock element; Separating a predefined quantity of the targets from another quantity of targets in the discharge tube by passing the predefined quantity of targets over the apex, retaining the remainder in the discharge tube by means of the apex; Coupling the exit port to a storage container and releasing the lock element to pass via gravity the predefined quantity of targets into the storage container. Systems for generating radionuclides and harvesting activated irradiation targets adapted to the above method are also provided.

Abstract: An irradiation target processing system for insertion and retrieving irradiation targets into and from an instrumentation tube in a nuclear reactor core comprises, a target retrieving system, target insertion system and transport gas supply system, mounted on a movable support, wherein: the target retrieving system comprises a target exit port coupled to a target storage container and exhaust system; the target insertion system comprises a target filling device, target retention tubing with target supply junction connectable to the instrumentation tube, and a target diverter coupled to the target filling device, target retention tubing and target retrieving system; and the transport gas supply system comprises a first gas supply tubing coupled to the exit port of the target retrieving system, a second gas supply tubing coupled to a junction for supplying gas to the instrumentation tube, and a transport gas supply junction coupled to the first and second gas supply tubing.

Abstract: To manufacture shaped bodies (10) filled with powder (22) for introduction into the reactor core of a commercial nuclear power reactor a plate made of a metal and/or metalloid is provided with one or more blind holes (14), the blind holes (14) are filled with powder (22), the blind holes (14) filled with powder (22) are reversibly sealed and shaped bodies are cut from the plate so that each blind hole (14) filled with powder (22) is surrounded by a shell made of a metal or metalloid. The powder-filled shaped bodies (10) are used in a ball measuring system for commercial nuclear power reactors and/or for the generation of radionuclides in said reactors.

Abstract: A method for harvesting activated irradiation targets (16) from an instrumentation tube system (12) of a nuclear reactor comprises the steps of: Coupling the instrumentation tube system (12) to a discharge tube (38) having an apex (50), an exit port (40) and a lock element (44) between the apex (50) and the exit port (40); Passing the activated irradiation targets (16) from the instrumentation tube system (12) into the discharge tube (38) and blocking movement of the activated irradiation targets (16) out of the discharge tube (38) by means of the lock element (44); Separating a predefined quantity (16?) of the activated irradiated targets (16) from another quantity (16?) of the targets (16) in the discharge tube (38); Coupling the exit port (40) to a storage container (42) and releasing the lock element (44) to pass the predefined quantity (16?) of the activated irradiation targets (16) under action of gravity into the storage container (42); wherein said separating step comprises passing the predefined quan

Abstract: An irradiation target processing system for insertion and retrieving irradiation targets into and from an instrumentation tube in a nuclear reactor core comprises, a target retrieving system, target insertion system and transport gas supply system, mounted on a movable support, wherein: the target retrieving system comprises a target exit port coupled to a target storage container and exhaust system; the target insertion system comprises a target filling device, target retention tubing with target supply junction connectable to the instrumentation tube, and a target diverter coupled to the target filling device, target retention tubing and target retrieving system; and the transport gas supply system comprises a first gas supply tubing coupled to the exit port of the target retrieving system, a second gas supply tubing coupled to a junction for supplying gas to the instrumentation tube, and a transport gas supply junction coupled to the first and second gas supply tubing.

Abstract: A radionuclide generation system comprises a tube system configured to permit insertion and removal of irradiation targets into an instrumentation finger of a nuclear reactor, and an irradiation target drive system configured to insert the irradiation targets into the instrumentation finger and to remove the irradiation targets from the instrumentation finger. The radionuclide generation system further comprises an instrumentation and control unit which is linked to an online core monitoring system and being configured to calculate an optimum irradiation time for the irradiation targets based on the actual state of the reactor as provided by the online core monitoring system.