Abstract: The present disclosure provides a training method and a prediction method for a diagenetic parameter prediction model based on an artificial intelligence algorithm, which includes: obtaining a plurality of diagenesis samples each including diagenetic condition parameters and an actual diagenetic parameter evolved therefrom; constructing an initial diagenetic parameter prediction model based on the diagenesis samples and a total dimension of the diagenetic condition parameters; and training the initial diagenetic parameter prediction model with the diagenesis samples so as to obtain a trained diagenetic parameter prediction model. The present disclosure can obtain a diagenetic parameter prediction model by training with the existing diagenesis samples, thereby solving problems of large amount of calculation, high uncertainty and large deviations in the prediction of the diagenetic parameters, which leads to a low evaluation accuracy of reservoirs and limits the oil and gas exploration.

Abstract: The present disclosure provides a method for recovering a porosity evolution process of sequence stratigraphy of carbonate rocks. The method comprises: a step of establishing a sequence stratigraphic framework of carbonate rocks; a step of dividing diagenetic stages; a step of simulating diagenesis and porosity evolution with increasing reservoir thickness and continuous superposition of multiple reservoirs during cyclic rise and fall of sea level to obtain a simulation result; and a step of calculating the porosity evolution in space over time by using the simulation result as initial values for simulation of diagenetic evolution process and simulating in stages and continuity the multi-stage diagenetic evolution process that the carbonate rock strata undergo after sediment based on the divided diagenetic stages.

Abstract: The present disclosure provides a method for recovering a porosity evolution process of sequence stratigraphy of carbonate rocks. The method comprises: a step of establishing a sequence stratigraphic framework of carbonate rocks; a step of dividing diagenetic stages; a step of simulating diagenesis and porosity evolution with increasing reservoir thickness and continuous superposition of multiple reservoirs during cyclic rise and fall of sea level to obtain a simulation result; and a step of calculating the porosity evolution in space over time by using the simulation result as initial values for simulation of diagenetic evolution process and simulating in stages and continuity the multi-stage diagenetic evolution process that the carbonate rock strata undergo after sediment based on the divided diagenetic stages.

Abstract: The present application falls within the field of drug synthesis, and in particular, the present application relates to a method for preparing ruxolitinib, and a method for preparing the intermediate and relevant intermediates used. The method comprises reacting a compound of formula II with a compound of formula IV or a salt thereof to obtain a compound of formula III, and then subjecting the compound of formula III to an acyl halogenation reaction, an amidation reaction, and a reaction dehydrating an amide to form a cyano group or removing the protecting group to prepare ruxolitinib. The method has the characteristics of brief steps, a high stereoselectivity, a high utilization ratio of atoms, mild reaction conditions and convenient post treatment. The method avoids using expensive asymmetric reaction catalysts, and is suitable for industrial production.

Abstract: The present application relates to a method for preparing Ibutinib as shown by the following synthetic route and the intermediate compounds involved therein.

Abstract: The present application falls within the field of drug synthesis, and in particular, the present application relates to a method for preparing ruxolitinib, and a method for preparing the intermediate and relevant intermediates used. The method comprises reacting a compound of formula II with a compound of formula IV or a salt thereof to obtain a compound of formula III, and then subjecting the compound of formula III to an acyl halogenation reaction, an amidation reaction, and a reaction dehydrating an amide to form a cyano group or removing the protecting group to prepare ruxolitinib. The method has the characteristics of brief steps, a high stereoselectivity, a high utilization ratio of atoms, mild reaction conditions and convenient post treatment. The method avoids using expensive asymmetric reaction catalysts, and is suitable for industrial production.

Abstract: Provided are apparatuses and methods for super resolution imaging photolithography. An exemplary apparatus may include an illumination light generation device configured to generate illumination light for imaging a pattern included in a mask through the mask. The illumination light may include a high-frequency spatial spectrum such that a high-frequency evanescent wave component of spatial spectrum information for the light is converted to a low-frequency evanescent wave component after being transmitted through the mask pattern. For example, the illumination light generation device may be configured to form the illumination in accordance with a high numerical aperture (NA) illumination mode and/or a surface plasmon (SP) wave illumination mode.

Abstract: The present application relates to a method for preparing Ibutinib as shown by the following synthetic route and the intermediate compounds involved therein.

Abstract: Provided are apparatuses and methods for super resolution imaging photolithography. An exemplary apparatus may include an illumination light generation device configured to generate illumination light for imaging a pattern included in a mask through the mask. The illumination light may include a high-frequency spatial spectrum such that a high-frequency evanescent wave component of spatial spectrum information for the light is converted to a low-frequency evanescent wave component after being transmitted through the mask pattern. For example, the illumination light generation device may be configured to form the illumination in accordance with a high numerical aperture (NA) illumination mode and/or a surface plasmon (SP) wave illumination mode.