Abstract: The present disclosure discloses a polypeptide, derivative thereof or pharmaceutically acceptable salt thereof. The polypeptide, derivative thereof, or pharmaceutically acceptable salt thereof has a structure (U—X1SHX4SX6X7X8X9X10X11X12X13X14X15X16X17X18X19X20DX22PX24TDVGAGSX32—NH2) as represented by formula (I) and a modifying group. The structure represented by formula (I) includes two amino acids Z1 or two amino acids Z2. The sites of the two amino acids Z1 or the two amino acids Z2 are Xi and Xi+7 respectively, where i is any integer between 6 and 13. The modifying group is bound to the two amino acids Z1 or the two amino acids Z2 via covalent bonds. The polypeptide or derivative thereof has certain activation activity on amylin receptor and calcitonin receptor simultaneously, and has long in-vivo half-life through modification of side chain modifying groups so as to support low-dose and low-frequency administration, and can be used for preventing or treating metabolic related diseases.

Abstract: Provided is a polypeptide or a derivative thereof or a pharmaceutically acceptable salt thereof. The polypeptide or the derivative thereof comprises a structure as represented by Formula (I): X1X2X3GTX6X7X8DX10X11X12X13X14X15X16X17X18X19X20X21X22X23X24X25LX27X28X29X30P X32SX34X35PPPX39 (I). The structure represented by Formula (I) comprises two amino acids with —SH on the side chain or two amino acids the side chain containing —NH2, —SH or —NH2 being used for linking a modification group. The polypeptide or the derivative thereof or the pharmaceutically acceptable salt thereof exhibits strong agonistic activity on three receptor targets of GLP-1R, GCGR and GIPR, can effectively control blood sugar and reduce body 10 weight, and can be used for preventing or treating metabolic disorder related diseases and the like.

Abstract: An electronic device may have a hinge that allows the device to be flexed about a bend axis. A display may span the bend axis. To facilitate bending about the bend axis without damage, the display may include a display cover layer with a flexible portion. The flexible portion of the display cover layer may be interposed between first and second rigid portions of the display cover layer. The display cover layer may also include a layer with self-healing properties. The layer of self-healing material may be formed across the entire display cover layer or may be formed only in the flexible region of the display cover layer. The display cover layer may include a layer of elastomer in the flexible region of the display cover layer for increased flexibility. Self-healing may be initiated or expedited by externally applied heat, light, electric current, or other type of external stimulus.

Abstract: An electronic device may have a hinge that allows the device to be flexed about a bend axis. A display may span the bend axis. To facilitate bending about the bend axis without damage, the display may include a display cover layer with a flexible portion. The flexible portion of the display cover layer may be interposed between first and second rigid portions of the display cover layer. The display cover layer may also include a layer with self-healing properties. The layer of self-healing material may be formed across the entire display cover layer or may be formed only in the flexible region of the display cover layer. The display cover layer may include a layer of elastomer in the flexible region of the display cover layer for increased flexibility. Self-healing may be initiated or expedited by externally applied heat, light, electric current, or other type of external stimulus.

Abstract: An electronic device may have a hinge that allows the device to be flexed about a bend axis. A display may span the bend axis. To facilitate bending about the bend axis without damage, the display may include a display cover layer with a flexible portion. The flexible portion of the display cover layer may be interposed between first and second rigid portions of the display cover layer. The display cover layer may also include a layer with self-healing properties. The layer of self-healing material may be formed across the entire display cover layer or may be formed only in the flexible region of the display cover layer. The display cover layer may include a layer of elastomer in the flexible region of the display cover layer for increased flexibility. Self-healing may be initiated or expedited by externally applied heat, light, electric current, or other type of external stimulus.

Abstract: A segmented grouting method for ramp drivage in an aquifer is provided. Concerning grouting reinforcement for a ramp in an aquifer, a grouting process is divided into four stages according to a pressure change, that is, micro-pressure filling, low-pressure diffusion, medium-pressure reinforcement, and high-pressure fracturing. In the micro-pressure filling, an initial pressure of a grouting orifice is 0, and a low-concentration single-component grout is used to fill an original fissure of the aquifer. In the low-pressure diffusion, a low-concentration bicomponent grout is used for grouting, the original fissure is expanded, and a grouting radius is increased. In the medium-pressure reinforcement, a high-concentration bicomponent grout is used for grouting, thereby reinforcing the aquifer. In the high-pressure fracturing, a high-concentration bicomponent grout is used to reinforce a new fractured fissure of the orifice caused by a high pressure and the original fissure, thereby forming a confining bed.

Abstract: An electronic device may have a hinge that allows the device to be flexed about a bend axis. A display may span the bend axis. To facilitate bending about the bend axis without damage, the display may include a display cover layer with a flexible portion. The flexible portion of the display cover layer may be interposed between first and second rigid portions of the display cover layer. The display cover layer may also include a layer with self-healing properties. The layer of self-healing material may be formed across the entire display cover layer or may be formed only in the flexible region of the display cover layer. The display cover layer may include a layer of elastomer in the flexible region of the display cover layer for increased flexibility. Self-healing may be initiated or expedited by externally applied heat, light, electric current, or other type of external stimulus.

Abstract: An electronic device may have a hinge that allows the device to be flexed about a bend axis. A display may span the bend axis. To facilitate bending about the bend axis without damage, the display may include a display cover layer with a flexible portion. The flexible portion of the display cover layer may be interposed between first and second rigid portions of the display cover layer. The display cover layer may also include a layer with self-healing properties. The layer of self-healing material may be formed across the entire display cover layer or may be formed only in the flexible region of the display cover layer. The display cover layer may include a layer of elastomer in the flexible region of the display cover layer for increased flexibility. Self-healing may be initiated or expedited by externally applied heat, light, electric current, or other type of external stimulus.

Abstract: An electronic device may have a hinge that allows the device to be flexed about a bend axis. A display may span the bend axis. To facilitate bending about the bend axis without damage, the display may include a display cover layer with a flexible portion. The flexible portion of the display cover layer may be interposed between first and second rigid portions of the display cover layer. The display cover layer may also include a layer with self-healing properties. The layer of self-healing material may be formed across the entire display cover layer or may be formed only in the flexible region of the display cover layer. The display cover layer may include a layer of elastomer in the flexible region of the display cover layer for increased flexibility. Self-healing may be initiated or expedited by externally applied heat, light, electric current, or other type of external stimulus.

Abstract: An electronic device may have a hinge that allows the device to be flexed about a bend axis. A display may span the bend axis. To facilitate bending about the bend axis without damage, the display may include a display cover layer with a flexible portion. The flexible portion of the display cover layer may be interposed between first and second rigid portions of the display cover layer. The display cover layer may also include a layer with self-healing properties. The layer of self-healing material may be formed across the entire display cover layer or may be formed only in the flexible region of the display cover layer. The display cover layer may include a layer of elastomer in the flexible region of the display cover layer for increased flexibility. Self-healing may be initiated or expedited by externally applied heat, light, electric current, or other type of external stimulus.

Abstract: A system and method for multi-spectral gas concentration analysis that includes using a library of multiple sets of optimized spectral sensitivities prepared in advance, and a multi-spectral IR gas analyzer tuned to a set of optimized spectral sensitivity. The multi-spectral IR gas analyzer measures spectral absorption of gas using one or more different sets of optimized spectral sensitivities.

Abstract: A method of quantifying gas leak rate includes receiving image frames acquired with a camera and including a plume from a gas leak source, determining a real-world size that each pixel represents, identifying pixels corresponding to the plume in a first image frame, calculating gas concentration path lengths of the plume for the pixels in the first image frame, calculating, based on the first image frame and a second image frame, an image velocity field of the plume including displacement vectors for the pixels, identifying, within the first image, a closed boundary enclosing the gas leak source of the plume, and calculating a first gas leak rate in the first image frame by calculating a volume rate of the plume flowing across the closed boundary based on the image velocity field, the gas concentration path lengths, and a time interval between the first and the second image frames.

Abstract: An electronic device may have a hinge that allows the device to be flexed about a bend axis. A display may span the bend axis. To facilitate bending about the bend axis without damage, the display may include a display cover layer with a flexible portion. The flexible portion of the display cover layer may be interposed between first and second rigid portions of the display cover layer. The display cover layer may also include a layer with self-healing properties. The layer of self-healing material may be formed across the entire display cover layer or may be formed only in the flexible region of the display cover layer. The display cover layer may include a layer of elastomer in the flexible region of the display cover layer for increased flexibility. Self-healing may be initiated or expedited by externally applied heat, light, electric current, or other type of external stimulus.

Abstract: A gas concentration-length quantification method may include: acquiring a multi-spectral image of detected radiance including a plurality of pixels using a multi-spectral optical gas imaging camera; estimating a background radiance for at least one of the pixels; calculating a gas concentration-length for the at least one of the pixels based on the detected radiance and the estimated background radiance; and triggering an alert when each alert condition in a list of alert conditions is satisfied. A multi-spectral configuration of the camera may include a reference band that is outside an absorption window of a target gas and an active band that includes at least a portion of the absorption window. Estimating the background radiance may include determining a model relating a detected radiance of the active band to a detected radiance of the reference band and using the model to estimate the background radiance for the active band.

Abstract: A method is provided for detecting faults in a conductive circuitry. The method includes: printing the conductive circuitry on top of a substrate using a printing head; heating the conductive circuitry with a heat source; scanning the heated conductive circuitry with a non-contact thermal detector; detecting, with the non-contact thermal detector and concurrently with the printing of the conductive circuitry, the faults where the printing head failed to print; and reprinting the faults with the printing head.

Abstract: A light emitting device includes a substrate layer, a first electrode layer, a light emitting layer, and a patterned second electrode layer. The patterned second electrode layer includes a periodic grating structure having a grating period ?g less than or equal to 200 nm and the patterned second electrode layer and the light emitting layer are separated by at most 100 nm.