Patents by Inventor Lekhram Changoer
Lekhram Changoer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11890361Abstract: This application discloses oral care compositions comprising cannabinoids, preferably cannabidiol and/or cannabigerol. The oral care composition disclosed in this application may be a tooth paste, a tooth powder, or a mouthwash solution. The oral care composition may be used to treat oral infectious disease, including periimplantitis, periodontitis, oral mucositis, and dental pain.Type: GrantFiled: July 2, 2020Date of Patent: February 6, 2024Assignee: APIRx Pharmaceutical USA, LLCInventors: George Anastassov, Lekhram Changoer
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Publication number: 20230241078Abstract: The current invention relates to the use of a physiologically acceptable organic and/or inorganic vanadium compound or complex, such as for example bis(maltolato)oxovanadium (BMOV) in the prevention or amelioration of stress-induced metabolic derangement in a subject. More in particular, the invention relates to a physiologically acceptable organic and/or inorganic vanadium compound or complex for use in the amelioration of hyperglycemia in a subject suffering from stress such as elicited by a trauma, wherein the physiologically acceptable organic and/or inorganic vanadium compound or complex is administered to said subject before the trauma is inflicted to the subject.Type: ApplicationFiled: January 13, 2023Publication date: August 3, 2023Applicant: CFM Pharma Holding B.V.Inventors: Hendrik Jan Cornelis Meijerink, Josephus Johannes De Kimpe, Lekhram Changoer
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Publication number: 20230241085Abstract: The present invention generally relates to a sugar alcohol and cannabinoid complex, and methods to prepare this complex from cannabinoid oil comprising at least one cannabinoid. The complex is in solid form and may be used in food, pharmaceutical, cosmetic formulations, and medical devices wherein solid forms of cannabinoid are desirable. This complex also enhances release of active cannabinoids in oral consumption. Methods to make this complex are also disclosed.Type: ApplicationFiled: April 11, 2023Publication date: August 3, 2023Applicant: APIRx Pharmaceutical USA, LLCInventors: George Anastassov, Lekhram Changoer
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Publication number: 20230115025Abstract: The invention relates to floating drug delivery systems (FDDS) that provide solutions to the particular problems often encountered with floating drug delivery systems described in the art. On such generally recognized problem is the vulnerability of the systems, especially damage to the gas-filled compartment making it accessible to water so as to impair its buoyancy, ultimately resulting in insufficient gastric residence time. The invention, in an aspect, provides a self-repairing FDDS that maintains its floating capacity after damaging. The floating drug delivery systems of the invention, furthermore, allow for incorporation of high loads of active ingredients. The floating drug delivery systems can be designed in such a way that release of active ingredient from the system occurs entirely independent from the pH of the fluid surrounding the system.Type: ApplicationFiled: June 7, 2022Publication date: April 13, 2023Applicant: APeT Holding B.V.Inventors: Hendrik Jan Cornelis Meijerink, Lekhram Changoer, Willem Blom, Marinella Regina Visser, Henderik Willem Frijlink, Anko Cornelus Eissens
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Publication number: 20230050166Abstract: A method to treat the skin condition vitiligo is described in this invention. The method comprises topical application of a composition containing cannabinoids, in particular cannabidiol and cannabigerol, at a concentration of 3%-20% by weight of the composition onto the affected skin area of a subject in need thereof. Application may be twice (2) daily for about six (6) weeks. Cannabidiol and cannabigerol may be sourced naturally or synthetically.Type: ApplicationFiled: September 29, 2022Publication date: February 16, 2023Applicant: APIRx Pharmaceutical USA, LLCInventors: Lekhram Changoer, George Anastassov
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Patent number: 11484510Abstract: A method to treat the skin condition vitiligo is described in this invention. The method comprises topical application of a composition containing cannabinoids, in particular cannabidiol and cannabigerol, at a concentration of 3%-20% by weight of the composition onto the affected skin area of a subject in need thereof. Application may be twice (2) daily for about six (6) weeks. Cannabidiol and cannabigerol may be sourced naturally or synthetically.Type: GrantFiled: August 21, 2018Date of Patent: November 1, 2022Assignee: APIRx Pharmaceutical USA, LLCInventors: Lekhram Changoer, George Anastassov
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Publication number: 20220304925Abstract: This invention relates to a suppository composition comprising cannabinoids. The suppository composition is formulated for easy absorption through mucosal membrane. The suppository as provided herein is useful for administration of cannabinoids in patients with nausea, vomiting, other conditions preventing swallowing, or conditions wherein suppository administration is required. Methods to manufacture the suppository composition are provided. Methods to treat pain, nausea, post-operative ileus and/or inflammatory bowel diseases using the suppository according to this invention are also provided.Type: ApplicationFiled: March 28, 2021Publication date: September 29, 2022Applicant: APIRx Pharmaceutical USA, LLCInventors: Lekhram CHANGOER, George ANASTASSOV
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Publication number: 20220040195Abstract: The present invention relates to a method for maintaining normoglycemia in a mammal in need thereof, preferably a critically ill patient suffering from acute stress, and to a method for preventing or limiting renal ischemia-reperfusion (I/R) in a mammal, preferably in a critically ill patient suffering from acute stress.Type: ApplicationFiled: October 22, 2021Publication date: February 10, 2022Applicant: CFM Pharma Holding BVInventors: Hendrik Jan Cornelis Meijerink, Lekhram Changoer
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Patent number: 11179401Abstract: The present invention relates to a method for maintaining normoglycemia in a mammal in need thereof, preferably a critically ill patient suffering from acute stress, and to a method for preventing or limiting renal ischemia-reperfusion (I/R) in a mammal, preferably in a critically ill patient suffering from acute stress.Type: GrantFiled: September 16, 2019Date of Patent: November 23, 2021Assignee: CFM PHARMA HOLDING BVInventors: Hendrik Jan Cornelis Meijerink, Lekhram Changoer
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Patent number: 11091455Abstract: ?9-THC carboxylic acid is extracted from cannabis flowers using a first organic solvent, then separated using a second aqueous solvent. ?9-THC carboxylic acid is converted to ?9-THC carboxylic salt before being extracted by a third organic solvent and converted back to ?9-THC carboxylic acid. Using a solvent swap, ?9-THC carboxylic acid is decarboxylated and extracted again with an organic solvent prior to purification to give ?9-THC.Type: GrantFiled: January 28, 2020Date of Patent: August 17, 2021Assignee: APIRx Pharmaceutical USA, LLCInventors: Lekhram Changoer, Cornelis Herman Michel Van Der Loo, Erik Keller
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Patent number: 11058646Abstract: This invention discloses anti-bacterial and anti-fungal compositions in spray form, in cream form, in liquid form, and in powder form. The anti-bacterial and anti-fungal compositions comprise cannabinoids, specifically cannabidiol, cannabigerol, tetrahydrocannabinol, tetracannabidivarin, and/or cannabidivarin for anti-bacterial and anti-fungal activities. The anti-bacterial and anti-fungal compositions may be used to treat toe nail fungus, MRSA infection, herpes virus infection, tinea pedis, burn wound infections, sun burns, diabetic infections, eczema, impetigo, dermatophytosis, psoriasis, itchy skin, atopic dermatitis, dandruff, and general topical infections.Type: GrantFiled: August 20, 2019Date of Patent: July 13, 2021Assignee: APIRx Pharmaceutical USA, LLCInventors: George E. Anastassov, Lekhram Changoer, Philippus Anne Van Damme
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Patent number: 10959978Abstract: This invention relates to a suppository composition comprising cannabinoids. The suppository composition is formulated for easy absorption through mucosal membrane. The suppository as provided herein is useful for administration of cannabinoids in patients with nausea, vomiting, other conditions preventing swallowing, or conditions wherein suppository administration is required. Methods to manufacture the suppository composition are provided. Methods to treat pain, nausea, post-operative ileus and/or inflammatory bowel diseases using the suppository according to this invention are also provided.Type: GrantFiled: December 11, 2019Date of Patent: March 30, 2021Assignee: APIRX Pharmaceutical USA, LLCInventors: Lekhram Changoer, George Anastassov
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Patent number: 10881614Abstract: The present invention relates to compositions and methods for the prophylaxis or treatment of deficiencies in essential amino acid absorption and metabolism and/or of a pathology or symptom associated there with. In particular the invention concerns the treatment and/or prevention of ADHD, ADD and autism spectrum disorders. The present inventors have developed a method for prophylaxis or treatment of such symptoms and/or pathologies associated with a deficiency in essential amino acid absorption and/or metabolism, which method, stated generally, relies on the administration of nicotinamide, typically in a long-acting formulation so as to overcome the deficiencies of existing formulations, which have proven unsuitable for effective treatment.Type: GrantFiled: September 28, 2017Date of Patent: January 5, 2021Assignee: APeT Holding B.V.Inventors: Hendrik Jan Cornelis Meijerink, Lekhram Changoer, Willem Blom, Marinella Regina Visser, Henderik Willem Frijlink, Anko Cornelus Eissens
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Patent number: 10842786Abstract: A chewing gum composition comprising cannabinoids or derivatives thereof and nicotine in the form of nicotine polacrilex is provided. The chewing gum composition is formulated to provide rapid and controlled release of cannabinoids and nicotine during chewing. Methods to provide tobacco and/or cannabis smoking cessation using the chewing gum composition according to this invention are also provided.Type: GrantFiled: April 23, 2017Date of Patent: November 24, 2020Assignee: APIRx Pharmaceutical USA, LLCInventors: Lekhram Changoer, George Anastassov
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Publication number: 20200330339Abstract: This application discloses oral care compositions comprising cannabinoids, preferably cannabidiol and/or cannabigerol. The oral care composition disclosed in this application may be a tooth paste, a tooth powder, or a mouthwash solution. The oral care composition may be used to treat oral infectious disease, including periimplantitis, periodontitis, oral mucositis, and dental pain.Type: ApplicationFiled: July 2, 2020Publication date: October 22, 2020Inventors: George ANASTASSOV, Lekhram CHANGOER
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Publication number: 20200246352Abstract: The current invention relates to the use of a physiologically acceptable organic and/or inorganic vanadium compound or complex, such as for example bis(maltolato)oxovanadium (BMOV) in the prevention or amelioration of stress-induced metabolic derangement in a subject. More in particular, the invention relates to a physiologically acceptable organic and/or inorganic vanadium compound or complex for use in the amelioration of hyperglycemia in a subject suffering from stress such as elicited by a trauma, wherein the physiologically acceptable organic and/or inorganic vanadium compound or complex is administered to said subject before the trauma is inflicted to the subject.Type: ApplicationFiled: September 21, 2018Publication date: August 6, 2020Applicant: CFM Pharma Holding B.V.Inventors: Hendrik Jan Cornelis Meijerink, Josephus Johannes de Kimpe, Lekhram Changoer
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Publication number: 20200188325Abstract: This invention discloses various cosmetics and topical formulations comprising cannabigerol, a non-psychoactive cannabinoid. The formulation may be an anti-aging cream for day or night application, a hand and nail cream, an eye cream, an acne treatment cream or tonic, an anti-diaper rash cream, a shampoo, a conditioner, a body wash, a face wash, deodorant spray, or a lip balm formulation. These topical and cosmetic formulations have speedy wound healing, skin firming, anti-bacterial, anti-dandruff, skin soothing, and UV ray protection properties.Type: ApplicationFiled: February 6, 2020Publication date: June 18, 2020Inventors: Lekhram Changoer, George Anastassov
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Publication number: 20200165219Abstract: ?9-THC carboxylic acid is extracted from cannabis flowers using a first organic solvent, then separated using a second aqueous solvent. ?9-THC carboxylic acid is converted to ?9-THC carboxylic salt before being extracted by a third organic solvent and converted back to ?9-THC carboxylic acid. Using a solvent swap, ?9-THC carboxylic acid is decarboxylated and extracted again with an organic solvent prior to purification to give ?9-THC.Type: ApplicationFiled: January 28, 2020Publication date: May 28, 2020Inventors: Lekhram CHANGOER, Cornelis Herman Michel VAN DER LOO, Erik KELLER
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Publication number: 20200108046Abstract: This invention relates to a suppository composition comprising cannabinoids. The suppository composition is formulated for easy absorption through mucosal membrane. The suppository as provided herein is useful for administration of cannabinoids in patients with nausea, vomiting, other conditions preventing swallowing, or conditions wherein suppository administration is required. Methods to manufacture the suppository composition are provided. Methods to treat pain, nausea, post-operative ileus and/or inflammatory bowel diseases using the suppository according to this invention are also provided.Type: ApplicationFiled: December 11, 2019Publication date: April 9, 2020Inventors: Lekhram CHANGOER, George ANASTASSOV
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Publication number: 20200078372Abstract: The present invention relates to a method for maintaining normoglycemia in a mammal in need thereof, preferably a critically ill patient suffering from acute stress, and to a method for preventing or limiting renal ischemia-reperfusion (I/R) in a mammal, preferably in a critically ill patient suffering from acute stress.Type: ApplicationFiled: September 16, 2019Publication date: March 12, 2020Inventors: Hendrik Jan Cornelis MEIJERINK, Lekhram CHANGOER