Patents by Inventor Lekhram Changoer

Lekhram Changoer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11484510
    Abstract: A method to treat the skin condition vitiligo is described in this invention. The method comprises topical application of a composition containing cannabinoids, in particular cannabidiol and cannabigerol, at a concentration of 3%-20% by weight of the composition onto the affected skin area of a subject in need thereof. Application may be twice (2) daily for about six (6) weeks. Cannabidiol and cannabigerol may be sourced naturally or synthetically.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: November 1, 2022
    Assignee: APIRx Pharmaceutical USA, LLC
    Inventors: Lekhram Changoer, George Anastassov
  • Publication number: 20220304925
    Abstract: This invention relates to a suppository composition comprising cannabinoids. The suppository composition is formulated for easy absorption through mucosal membrane. The suppository as provided herein is useful for administration of cannabinoids in patients with nausea, vomiting, other conditions preventing swallowing, or conditions wherein suppository administration is required. Methods to manufacture the suppository composition are provided. Methods to treat pain, nausea, post-operative ileus and/or inflammatory bowel diseases using the suppository according to this invention are also provided.
    Type: Application
    Filed: March 28, 2021
    Publication date: September 29, 2022
    Applicant: APIRx Pharmaceutical USA, LLC
    Inventors: Lekhram CHANGOER, George ANASTASSOV
  • Publication number: 20220040195
    Abstract: The present invention relates to a method for maintaining normoglycemia in a mammal in need thereof, preferably a critically ill patient suffering from acute stress, and to a method for preventing or limiting renal ischemia-reperfusion (I/R) in a mammal, preferably in a critically ill patient suffering from acute stress.
    Type: Application
    Filed: October 22, 2021
    Publication date: February 10, 2022
    Applicant: CFM Pharma Holding BV
    Inventors: Hendrik Jan Cornelis Meijerink, Lekhram Changoer
  • Patent number: 11179401
    Abstract: The present invention relates to a method for maintaining normoglycemia in a mammal in need thereof, preferably a critically ill patient suffering from acute stress, and to a method for preventing or limiting renal ischemia-reperfusion (I/R) in a mammal, preferably in a critically ill patient suffering from acute stress.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: November 23, 2021
    Assignee: CFM PHARMA HOLDING BV
    Inventors: Hendrik Jan Cornelis Meijerink, Lekhram Changoer
  • Patent number: 11091455
    Abstract: ?9-THC carboxylic acid is extracted from cannabis flowers using a first organic solvent, then separated using a second aqueous solvent. ?9-THC carboxylic acid is converted to ?9-THC carboxylic salt before being extracted by a third organic solvent and converted back to ?9-THC carboxylic acid. Using a solvent swap, ?9-THC carboxylic acid is decarboxylated and extracted again with an organic solvent prior to purification to give ?9-THC.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: August 17, 2021
    Assignee: APIRx Pharmaceutical USA, LLC
    Inventors: Lekhram Changoer, Cornelis Herman Michel Van Der Loo, Erik Keller
  • Patent number: 11058646
    Abstract: This invention discloses anti-bacterial and anti-fungal compositions in spray form, in cream form, in liquid form, and in powder form. The anti-bacterial and anti-fungal compositions comprise cannabinoids, specifically cannabidiol, cannabigerol, tetrahydrocannabinol, tetracannabidivarin, and/or cannabidivarin for anti-bacterial and anti-fungal activities. The anti-bacterial and anti-fungal compositions may be used to treat toe nail fungus, MRSA infection, herpes virus infection, tinea pedis, burn wound infections, sun burns, diabetic infections, eczema, impetigo, dermatophytosis, psoriasis, itchy skin, atopic dermatitis, dandruff, and general topical infections.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: July 13, 2021
    Assignee: APIRx Pharmaceutical USA, LLC
    Inventors: George E. Anastassov, Lekhram Changoer, Philippus Anne Van Damme
  • Patent number: 10959978
    Abstract: This invention relates to a suppository composition comprising cannabinoids. The suppository composition is formulated for easy absorption through mucosal membrane. The suppository as provided herein is useful for administration of cannabinoids in patients with nausea, vomiting, other conditions preventing swallowing, or conditions wherein suppository administration is required. Methods to manufacture the suppository composition are provided. Methods to treat pain, nausea, post-operative ileus and/or inflammatory bowel diseases using the suppository according to this invention are also provided.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: March 30, 2021
    Assignee: APIRX Pharmaceutical USA, LLC
    Inventors: Lekhram Changoer, George Anastassov
  • Patent number: 10881614
    Abstract: The present invention relates to compositions and methods for the prophylaxis or treatment of deficiencies in essential amino acid absorption and metabolism and/or of a pathology or symptom associated there with. In particular the invention concerns the treatment and/or prevention of ADHD, ADD and autism spectrum disorders. The present inventors have developed a method for prophylaxis or treatment of such symptoms and/or pathologies associated with a deficiency in essential amino acid absorption and/or metabolism, which method, stated generally, relies on the administration of nicotinamide, typically in a long-acting formulation so as to overcome the deficiencies of existing formulations, which have proven unsuitable for effective treatment.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: January 5, 2021
    Assignee: APeT Holding B.V.
    Inventors: Hendrik Jan Cornelis Meijerink, Lekhram Changoer, Willem Blom, Marinella Regina Visser, Henderik Willem Frijlink, Anko Cornelus Eissens
  • Patent number: 10842786
    Abstract: A chewing gum composition comprising cannabinoids or derivatives thereof and nicotine in the form of nicotine polacrilex is provided. The chewing gum composition is formulated to provide rapid and controlled release of cannabinoids and nicotine during chewing. Methods to provide tobacco and/or cannabis smoking cessation using the chewing gum composition according to this invention are also provided.
    Type: Grant
    Filed: April 23, 2017
    Date of Patent: November 24, 2020
    Assignee: APIRx Pharmaceutical USA, LLC
    Inventors: Lekhram Changoer, George Anastassov
  • Publication number: 20200330339
    Abstract: This application discloses oral care compositions comprising cannabinoids, preferably cannabidiol and/or cannabigerol. The oral care composition disclosed in this application may be a tooth paste, a tooth powder, or a mouthwash solution. The oral care composition may be used to treat oral infectious disease, including periimplantitis, periodontitis, oral mucositis, and dental pain.
    Type: Application
    Filed: July 2, 2020
    Publication date: October 22, 2020
    Inventors: George ANASTASSOV, Lekhram CHANGOER
  • Publication number: 20200246352
    Abstract: The current invention relates to the use of a physiologically acceptable organic and/or inorganic vanadium compound or complex, such as for example bis(maltolato)oxovanadium (BMOV) in the prevention or amelioration of stress-induced metabolic derangement in a subject. More in particular, the invention relates to a physiologically acceptable organic and/or inorganic vanadium compound or complex for use in the amelioration of hyperglycemia in a subject suffering from stress such as elicited by a trauma, wherein the physiologically acceptable organic and/or inorganic vanadium compound or complex is administered to said subject before the trauma is inflicted to the subject.
    Type: Application
    Filed: September 21, 2018
    Publication date: August 6, 2020
    Applicant: CFM Pharma Holding B.V.
    Inventors: Hendrik Jan Cornelis Meijerink, Josephus Johannes de Kimpe, Lekhram Changoer
  • Publication number: 20200188325
    Abstract: This invention discloses various cosmetics and topical formulations comprising cannabigerol, a non-psychoactive cannabinoid. The formulation may be an anti-aging cream for day or night application, a hand and nail cream, an eye cream, an acne treatment cream or tonic, an anti-diaper rash cream, a shampoo, a conditioner, a body wash, a face wash, deodorant spray, or a lip balm formulation. These topical and cosmetic formulations have speedy wound healing, skin firming, anti-bacterial, anti-dandruff, skin soothing, and UV ray protection properties.
    Type: Application
    Filed: February 6, 2020
    Publication date: June 18, 2020
    Inventors: Lekhram Changoer, George Anastassov
  • Publication number: 20200165219
    Abstract: ?9-THC carboxylic acid is extracted from cannabis flowers using a first organic solvent, then separated using a second aqueous solvent. ?9-THC carboxylic acid is converted to ?9-THC carboxylic salt before being extracted by a third organic solvent and converted back to ?9-THC carboxylic acid. Using a solvent swap, ?9-THC carboxylic acid is decarboxylated and extracted again with an organic solvent prior to purification to give ?9-THC.
    Type: Application
    Filed: January 28, 2020
    Publication date: May 28, 2020
    Inventors: Lekhram CHANGOER, Cornelis Herman Michel VAN DER LOO, Erik KELLER
  • Publication number: 20200108046
    Abstract: This invention relates to a suppository composition comprising cannabinoids. The suppository composition is formulated for easy absorption through mucosal membrane. The suppository as provided herein is useful for administration of cannabinoids in patients with nausea, vomiting, other conditions preventing swallowing, or conditions wherein suppository administration is required. Methods to manufacture the suppository composition are provided. Methods to treat pain, nausea, post-operative ileus and/or inflammatory bowel diseases using the suppository according to this invention are also provided.
    Type: Application
    Filed: December 11, 2019
    Publication date: April 9, 2020
    Inventors: Lekhram CHANGOER, George ANASTASSOV
  • Publication number: 20200078372
    Abstract: The present invention relates to a method for maintaining normoglycemia in a mammal in need thereof, preferably a critically ill patient suffering from acute stress, and to a method for preventing or limiting renal ischemia-reperfusion (I/R) in a mammal, preferably in a critically ill patient suffering from acute stress.
    Type: Application
    Filed: September 16, 2019
    Publication date: March 12, 2020
    Inventors: Hendrik Jan Cornelis MEIJERINK, Lekhram CHANGOER
  • Publication number: 20200038421
    Abstract: The present invention generally relates to a sugar alcohol and cannabinoid complex, and methods to prepare this complex from cannabinoid oil comprising at least one cannabinoid. The complex is in solid form and may be used in food, pharmaceutical, cosmetic formulations, and medical devices wherein solid forms of cannabinoid are desirable. This complex also enhances release of active cannabinoids in oral consumption. Methods to make this complex are also disclosed.
    Type: Application
    Filed: October 15, 2019
    Publication date: February 6, 2020
    Inventors: George Anastassov, Lekhram Changoer
  • Patent number: 10543190
    Abstract: This invention relates to a suppository composition comprising cannabinoids. The suppository composition is formulated for easy absorption through mucosal membrane. The suppository as provided herein is useful for administration of cannabinoids in patients with nausea, vomiting, other conditions preventing swallowing, or conditions wherein suppository administration is required. Methods to manufacture the suppository composition are provided. Methods to treat pain, nausea, post-operative ileus and/or inflammatory bowel diseases using the suppository according to this invention are also provided.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: January 28, 2020
    Assignee: Axim Biotechnologies, Inc.
    Inventors: Lekhram Changoer, George Anastassov
  • Publication number: 20200016095
    Abstract: This invention discloses anti-bacterial and anti-fungal compositions in spray form, in cream form, in liquid form, and in powder form. The anti-bacterial and anti-fungal compositions comprise cannabinoids, specifically cannabidiol, cannabigerol, tetrahydrocannabinol, tetracannabidivarin, and/or cannabidivarin for anti-bacterial and anti-fungal activities. The anti-bacterial and anti-fungal compositions may be used to treat toe nail fungus, MRSA infection, herpes virus infection, tinea pedis, burn wound infections, sun burns, diabetic infections, eczema, impetigo, dermatophytosis, psoriasis, itchy skin, atopic dermatitis, dandruff, and general topical infections.
    Type: Application
    Filed: August 20, 2019
    Publication date: January 16, 2020
    Inventors: George E. Anastassov, Lekhram Changoer, Phillippus Anne Van Damme
  • Patent number: 10449204
    Abstract: The present invention relates to a method for maintaining normoglycemia in a mammal in need thereof, preferably a critically ill patient suffering from acute stress, and to a method for preventing or limiting renal ischemia-reperfusion (I/R) in a mammal, preferably in a critically ill patient suffering from acute stress.
    Type: Grant
    Filed: March 6, 2012
    Date of Patent: October 22, 2019
    Assignee: CFM PHARMA HOLDING BV
    Inventors: Hendrik Jan Cornelis, Lekhram Changoer
  • Patent number: 10441552
    Abstract: This invention discloses anti-bacterial and anti-fungal compositions in spray form, in cream form, in liquid form, and in powder form. The anti-bacterial and anti-fungal compositions comprise cannabinoids, specifically cannabidiol, cannabigerol, tetrahydrocannabinol, tetracannabidivarin, and/or cannabidivarin for anti-bacterial and anti-fungal activities. The anti-bacterial and anti-fungal compositions may be used to treat toe nail fungus, MRSA infection, herpes virus infection, tinea pedis, burn wound infections, sun burns, diabetic infections, eczema, impetigo, dermatophytosis, psoriasis, itchy skin, atopic dermatitis, dandruff, and general topical infections.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: October 15, 2019
    Assignee: Axim Biotechnologies, Inc.
    Inventors: George E. Anastassov, Lekhram Changoer, Philippus Anne Van Damme