Abstract: Provided are a virus peptide-protein subunit combination vaccine based on DNA nanotechnology, and a preparation method therefor and use thereof, which belong to the technical field of biological products. Provided is a virus peptide-protein subunit combination vaccine based on DNA nanotechnology, in which a tetrahedral framework nucleic acid formed by assembly of DNA strands is used as a vector, a protein antigen triggering virus-specific T cell activation is coupled to one edge of the tetrahedral framework nucleic acid, and B cell epitope peptides of a virus are coupled to four vertices of the tetrahedral framework nucleic acid.

Abstract: A DNA adjuvant hydrogel-based peptide vaccine, and a preparation method and use thereof are provided, belonging to the technical field of biological products. The DNA adjuvant hydrogel-based peptide vaccine includes a peptide-carrier protein, a DNA hydrogel, and a free carrier protein; where the peptide-carrier protein is loaded in the DNA hydrogel or encapsulated in the DNA hydrogel by hybridization; the free carrier protein is encapsulated inside the DNA hydrogel; and the DNA hydrogel is self-assembled from a Y-shaped scaffold and a linker DNA. In the peptide vaccine, the free carrier protein is rapidly released to induce CD4+ T cell activation; while the peptide-carrier protein is slowly released, thereby achieving B cell sensitization while activating more CD4+ T cells. In this way, B cells are effectively activated to enhance an immune effect of the peptide vaccine.

Abstract: The present disclosure provides a display panel, a manufacturing method thereof and a display device. The display panel includes: a base substrate including a display region, a wiring region surrounding the display region and a bonding region located at a side of the display region; a light-emitting element arranged in the display region and including a cathode; and a first line and at least one second line in the wiring region, the first line being coupled to the cathode of the light-emitting element, two ends of the second line being coupled to the first line in the bonding region, and the first line and the second line being coupled through at least two via holes at an opposite side of the bonding region.

Abstract: The invention provides the use of an immunoadjuvant-based hydrogel in the preparing a sensitizing agent for surgical radiotherapy. The present invention also provides an immunoadjuvant-based hydrogel composition comprising sodium alginate, a tumor cell death marker aptamer, and a water-soluble immunoadjuvant with an extended sequence, wherein sodium alginate is covalently linked to the tumor cell death marker aptamer, and the sequence extended from the immunoadjuvant is partially complementary to the sequence of the tumor cell death marker aptamer. The immunoadjuvant-based hydrogel composition can undergo gelation in situ in the presence of calcium ions in the body, and realize the release of immune adjuvants in response to tumor cell death marker during tumor radiotherapy and the long-term intratumoral retention of immune adjuvant in the interval of radiotherapy, thus activating tumor-specific immune response for a long time during radiotherapy, and inhibiting the systemic metastasis of tumors.

Abstract: The present disclosure provides a display panel, a manufacturing method thereof and a display device. The display panel includes: a base substrate including a display region, a wiring region surrounding the display region and a bonding region located at a side of the display region; a light-emitting element arranged in the display region and including a cathode; and a first line and at least one second line in the wiring region, the first line being coupled to the cathode of the light-emitting element, two ends of the second line being coupled to the first line in the bonding region, and the first line and the second line being coupled through at least two via holes at an opposite side of the bonding region.

Abstract: A dimension detection device includes a first detection unit which is moved to a first predetermined position in a first direction, and configured to detect a current position of the first member, and when the current position of the first member is not a third predetermined position corresponding to the first predetermined position, send a first signal; a second detection unit which is moved to a second predetermined position in the first direction, and configured to detect a current position of the second member, and when the current position of the second member is not a fourth predetermined position corresponding to the second predetermined position, send a second signal; a movement unit which is configured to move the first detection unit and the second detection unit; and an alarm unit configured to send an alarm upon the receipt of the first signal and/or the second signal.

Abstract: The present disclosure provides a dynamic path linking method and device, and a mobile terminal. The method includes that: responding to a request for invoking the path of the primary memory, it is detected whether an external storage card exists; and the path of the primary memory is dynamically set to be a storage path of the external storage card or a storage path of an internal storage card according to a detection result. The present disclosure solves the problem that the path of the primary memory cannot be dynamically linked, thereby achieving an effect of improving user experience.

Abstract: A dimension detection device includes a first detection unit which is moved to a first predetermined position in a first direction, and configured to detect a current position of the first member, and when the current position of the first member is not a third predetermined position corresponding to the first predetermined position, send a first signal; a second detection unit which is moved to a second predetermined position in the first direction, and configured to detect a current position of the second member, and when the current position of the second member is not a fourth predetermined position corresponding to the second predetermined position, send a second signal; a movement unit which is configured to move the first detection unit and the second detection unit; and an alarm unit configured to send an alarm upon the receipt of the first signal and/or the second signal.