Patents by Inventor Lelia M. Fuentes

Lelia M. Fuentes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enantioselective process for producing 1-beta-methyl carbapenem antibiotic intermediates
    Patent number: 5104984
    Abstract: A process is described for the stereochemically controlled synthesis of intermediates useful in producing 1-betamethylcarbapenem antibiotic intermediates involving reacting a beta lactam with a chiral thia- or oxazolidinone enolate to preferentially produce a beta-methyl intermediate which can be transformed into a carbapenem antibiotic.
    Type: Grant
    Filed: July 11, 1990
    Date of Patent: April 14, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Thomas N. Salzmann, Lelia M. Fuentes, Ichiro Shinkai
  • Chiral 1-.beta.-methyl-carbapenem intermediates
    Patent number: 5075436
    Abstract: A multistep process is described for selectively obtaining 1-.beta.-methylcarbapenem intermediates in high overall yield. The desired 1-.beta.-methyl chirality is obtained through the hydrogenation of certain bicyclic .beta.-lactam ring structures containing an exocyclic methylene double bond alpha to the .beta.-lactam ring, in the presence of a metallic nickel hydrogenation catalyst. The hydrogenation results in a mixture of .alpha.- and .beta.-methyl isomers having a high .beta./.alpha.epimeric molar ratio. New 1-.beta.-methylcarbapenem intermediates containing the exocyclic double bond are also described.
    Type: Grant
    Filed: January 19, 1989
    Date of Patent: December 24, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Ichiro Shinkai, Anthony O. King, Lelia M. Fuentes
  • Process for bis(substituted phenyl) phosphorohalidates
    Patent number: 4845261
    Abstract: This invention relates to a novel process for preparing bis(substituted phenyl) phosphorohalidates.
    Type: Grant
    Filed: May 11, 1987
    Date of Patent: July 4, 1989
    Assignee: Merck & Co., Inc.
    Inventor: Lelia M. Fuentes
  • Enantioselective process for producing 1-betamethylcarbapenem antibiotic intermediates
    Patent number: 4791207
    Abstract: A process is described for the stereochemically controlled synthesis of intermediates useful in producing 1-betamethylcarbapenem antibiotics.
    Type: Grant
    Filed: May 4, 1987
    Date of Patent: December 13, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Thomas N. Salzmann, Lelia M. Fuentes, Ichiro Shinkai