Abstract: Described herein are systems and methods for microfluidic cell support, including a microfluidic cell support system and methods for its use. The microfluidic cell support system can include a base assembly, a manifold assembly, and a microfluidic celltray including a microcirculatory path in fluid communication with the manifold assembly. The microfluidic celltray can be microfluidically closed and mechanically open. In some aspects the microfluidic celltray contains one or more cell wells containing fluid for supporting living cell(s). In some aspects, the microcirculatory path provides active fluid flow between a microfluidic inflow channel and a microfluidic outflow channel.

Abstract: A method and system for providing a container for investigating at least one specimen are described. The method and system include providing a dish. The dish includes a floor, a plurality of sidewalls, and at least one pedestal. The floor has a perimeter. The plurality of sidewalls coupled with the floor proximate to the perimeter. The at least one pedestal resides on a portion of the floor and is pedestal configured to support at least one microscope slide distal from the floor. The at least one microscope slide bears the specimen(s) for investigation.

Abstract: A method and system for providing a cell support system are described. The method and system include providing a first block, a second block coupled to the first block, and a plurality of microfluidic channels. The first block includes a plurality of cell wells therein. The second block includes a plurality of through holes therethrough. The plurality of holes are in fluid communication with at least one corresponding cell well of the plurality of cell wells. The plurality of microfluidic channels are in fluid combination with at least a portion of the plurality of cell wells and are configured to provide an active fluid flow with the portion of the plurality of cell wells.

Abstract: A method and system for providing a container for investigating at least one specimen are described. The method and system include providing a dish. The dish includes a floor, a plurality of sidewalls, and at least one pedestal. The floor has a perimeter. The plurality of sidewalls coupled with the floor proximate to the perimeter. The at least one pedestal resides on a portion of the floor and is pedestal configured to support at least one microscope slide distal from the floor. The at least one microscope slide bears the specimen(s) for investigation.