Patents by Inventor Len Neckers

Len Neckers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novobiocin analogues as anticancer agents
    Patent number: 7811998
    Abstract: Novel analogues and derivatives of novobiocin are provided, including compounds having modifications to the amide side chain, coumarin ring, and sugar moieties. The compounds of the present invention are useful as heat shock protein 90 inhibitors, and may be used as anticancer and neuroprotective agents.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: October 12, 2010
    Assignees: University of Kansas, The United States of America as represented by the Department of Health and Human Services
    Inventors: Brian S. Blagg, Len Neckers, Xiao Ming Yu
  • Novobiocin Analogues as Anticancer Agents
    Publication number: 20100048882
    Abstract: Novel analogues and derivatives of novobiocin are provided, including compounds having modifications to the amide side chain, coumarin ring, and sugar moieties. The compounds of the present invention are useful as heat shock protein 90 inhibitors, and may be used as anticancer and neuroprotective agents.
    Type: Application
    Filed: October 1, 2009
    Publication date: February 25, 2010
    Applicant: UNIVERSITY OF KANSAS
    Inventors: Brian S. Blagg, Len Neckers, Xiao Ming Yu
  • Novobiocin analogues as anticancer agents
    Patent number: 7608594
    Abstract: Novel analogues and derivatives of novobiocin are provided, including compounds having modifications to the amide side chain, coumarin ring, and sugar moieties. The compounds of the present invention are useful as heat shock protein 90 inhibitors, and may be used as anticancer and neuroprotective agents.
    Type: Grant
    Filed: November 3, 2005
    Date of Patent: October 27, 2009
    Assignee: University of Kansas
    Inventors: Brian S. Blagg, Len Neckers, Xiao Ming Yu
  • Novobiocin analogues as anticancer agents
    Publication number: 20060199776
    Abstract: Novel analogues and derivatives of novobiocin are provided, including compounds having modifications to the amide side chain, coumarin ring, and sugar moieties. The compounds of the present invention are useful as heat shock protein 90 inhibitors, and may be used as anticancer and neuroprotective agents.
    Type: Application
    Filed: November 3, 2005
    Publication date: September 7, 2006
    Inventors: Brian Blagg, Len Neckers, Xiao Yu
  • Use of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase as a modality in cancer therapy
    Patent number: 6040334
    Abstract: Methods of treating various cancers, such as prostatic adenocarcinoma, with inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG Co-A), such as lovastatin, are provided. Dosing ranges, schedules and toxicities are included.
    Type: Grant
    Filed: October 20, 1994
    Date of Patent: March 21, 2000
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Charles Myers, Jane Trepel, Won Ki Kang, Luke Whitesell, Len Neckers
  • Inhibition of protein kinase activity by aptameric action of oligonucleotides
    Patent number: 5998596
    Abstract: The present invention are oligonucleotides that specifically bind to and directly inhibit the biological function of target molecules such as proteins, peptides or derivatives. The direct or aptameric interaction of oligonucleotides of the present invention with proteins, peptides and derivatives represents a non-antisense mediated effect. The oligonucleotides have been shown to bind to isolated target molecules and to inhibit biological function of the target molecule within cells. In particular, the oligonucleotides have been shown to directly inhibit the kinase activity of protein-tyrosine kinase. The oligonucleotides of the present invention have significant beneficial effects against a chronic myelogenous leukemia derived cell line as demonstrated using cellular phosphotyrosine content as well as cellular growth in soft agar.
    Type: Grant
    Filed: April 4, 1995
    Date of Patent: December 7, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Raymond Bergan, Len Neckers
  • Inhibitors for replication of retroviruses and for the expression of oncogene products
    Patent number: 5286717
    Abstract: Phosphorothioate oligodeoxyribonucleotide analogs can be used to prevent replication of foreign nucleic acids in the presence of normal living cells, as well as to inhibit the proliferation of neoplastic cells.
    Type: Grant
    Filed: November 16, 1992
    Date of Patent: February 15, 1994
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jack S. Cohen, Len Neckers, Cy Stein, She L. Loke, Kazuo Shinozuka
  • Inhibitors for replication of retroviruses and for the expression of oncogene products
    Patent number: 5276019
    Abstract: Phosphorothioate oligodeoxyribonucleotide analogs can be used to prevent replication of foreign nucleic acids in the presence of normal living cells, as well as to inhibit the proliferation of neoplastic cells.
    Type: Grant
    Filed: February 22, 1988
    Date of Patent: January 4, 1994
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jack S. Cohen, Len Neckers, Cy Stein, Shee L. Loke, Kazuo Shinozuka
  • Inhibitors for replication of retroviruses and for the expression of oncogene products
    Patent number: 5264423
    Abstract: Phosphorothioate oligodeoxyribonucleotide analogs can be used to prevent replication of foreign nucleic acids in the presence of normal living cells, as well as to inhibit the proliferation of neoplastic cells.
    Type: Grant
    Filed: November 16, 1992
    Date of Patent: November 23, 1993
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jack S. Cohen, Len Neckers, Cy Stein, She L. Loke, Kazuo Shinozuka