Patents by Inventor Len Pennacchio
Len Pennacchio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200087360Abstract: The present invention provides for a recombinant or isolated polypeptide comprising the amino acid sequence of an enhancer polypeptide associated with a diarrhea disorder; a transgenic non-human mammal, wherein the mammal is deleted or knocked out for one or more of an intestine-critical region (ICR); a pharmaceutical composition comprising the polypeptide of the present invention and a pharmaceutical acceptable carrier; and, a method of treating or preventing a subject suffering or at risk or suspected of suffering from a diarrhea disease or disorder, the method comprising administrating a pharmaceutical composition of the present invention to a subject in need of such treatment.Type: ApplicationFiled: May 22, 2019Publication date: March 19, 2020Applicant: The Regents of the University of CaliforniaInventors: Yiwen Zhu, Len A. Pennacchio
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Patent number: 9952216Abstract: Herein are described a set of novel specific human enhancers for specific forebrain cell types used to study and select for human neural progenitor cells. This approach enables the ability to generate interneurons from human ES, iPS and iN cells, making them available for human transplantation and for molecular/cellular analyzes. These approaches are also directly applicable to generating other neuronal cell types, such as cortical and striatal projection neurons, which have implications for many human diseases.Type: GrantFiled: October 10, 2014Date of Patent: April 24, 2018Assignee: The Regents of the University of CaliforniaInventors: Axel Visel, John L. R. Rubenstein, Ying-Jiun (Jasmine) Chen, Len A. Pennacchio, Daniel Vogt, Cory Nicholas, Arnold Kriegstein
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Patent number: 9469874Abstract: Methods for sequencing single large DNA molecules by clonal multiple displacement amplification using barcoded primers. Sequences are binned based on barcode sequences and sequenced using a microdroplet-based method for sequencing large polynucleotide templates to enable assembly of haplotype-resolved complex genomes and metagenomes.Type: GrantFiled: October 16, 2012Date of Patent: October 18, 2016Assignee: The Regents of the University of CaliforniaInventors: Feng Chen, Tao Zhang, Kanwar K. Singh, Len A. Pennacchio, Jeff L. Froula, Kevin S. Eng
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Publication number: 20150044187Abstract: Herein are described a set of novel specific human enhancers for specific forebrain cell types used to study and select for human neural progenitor cells. This approach enables the ability to generate interneurons from human ES, iPS and iN cells, making them available for human transplantation and for molecular/cellular analyses. These approaches are also directly applicable to generating other neuronal cell types, such as cortical and striatal projection neurons, which have implications for many human diseases.Type: ApplicationFiled: October 10, 2014Publication date: February 12, 2015Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Axel Visel, John L.R. Rubenstein, Ying-Jiun (aka, Jasmine) Chen, Len A. Pennacchio
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Publication number: 20150017649Abstract: Diagnostic and therapeutic applications for Noonan Syndrome are described. The diagnostic and therapeutic applications are based on certain mutations in a RAS-specific guanine nucleotide exchange factor gene SOS1 or its expression product. The diagnostic and therapeutic applications are also based on certain mutations in a serine/threonine protein kinase gene RAFl or its expression product thereof. Also described are nucleotide sequences, amino acid sequences, probes, and primers related to RAF1 or SOS1, and variants thereof, as well as host cells expressing such variants.Type: ApplicationFiled: June 20, 2014Publication date: January 15, 2015Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, MOUNT SINAI SCHOOL OF MEDICINEInventors: Bruce D. Gelb, Marco Tartaglia, Len Pennacchio
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Patent number: 8808992Abstract: The present invention is directed to methods of diagnosing Noonan-like syndrome with loose anagen hair comprising detecting a mutation in SHOC2 gene. One specific diagnostic mutation disclosed is an A-to-G transition at position 4 resulting in a mutation at position 2 of SHOC2 amino acid sequence from serine to glycine. The invention also provides related sequences and kits.Type: GrantFiled: May 6, 2010Date of Patent: August 19, 2014Assignees: Icahn School of Medicine at Mount Sinai, The Regents of the University of CaliforniaInventors: Bruce D. Gelb, Marco Tartaglia, Len Pennacchio, Ravi Iyengar, Avi Ma'ayan
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Publication number: 20130029332Abstract: Diagnostic and therapeutic applications for Noonan Syndrome are described. The diagnostic and therapeutic applications are based on certain mutations in a RAS-specific guanine nucleotide exchange factor gene SOS1 or its expression product. The diagnostic and therapeutic applications are also based on certain mutations in a serine/threonine protein kinase gen RAF1 or its expression product thereof. Also described are nucleotide sequences, amino acid sequences, probes, and primers related to RAF1 or SOS1, and variants thereof, as well as host cells expressing such variants.Type: ApplicationFiled: June 20, 2012Publication date: January 31, 2013Applicants: The Regents of the University of California, Mount Sinai School of MedicineInventors: Bruce D. Gelb, Marco Tartaglia, Len Pennacchio
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Patent number: 8221979Abstract: Diagnostic and therapeutic applications for Noonan Syndrome are described. The diagnostic and therapeutic applications are based on certain mutations in a RAS-specific guanine nucleotide exchange factor gene SOS1 or its expression product. The diagnostic and therapeutic applications are also based on certain mutations in a serine/threonine protein kinase gene RAF1 or its expression product thereof. Also described are nucleotide sequences, amino acid sequences, probes, and primers related to RAF1 or SOS1, and variants thereof, as well as host cells expressing such variants.Type: GrantFiled: November 16, 2007Date of Patent: July 17, 2012Assignees: Mount Sinai School of Medicine, The Regents of the University of CaliforniaInventors: Bruce D. Gelb, Marco Tartaglia, Len Pennacchio
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Publication number: 20110059851Abstract: The present invention is directed to methods of diagnosing Noonan-like syndrome with loose anagen hair comprising detecting a mutation in SHOC2 gene. One specific diagnostic mutation disclosed is an A-to-G transition at position 4 resulting in a mutation at position 2 of SHOC2 amino acid sequence from serine to glycine. The invention also provides related sequences and kits.Type: ApplicationFiled: May 6, 2010Publication date: March 10, 2011Applicant: MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITYInventors: BRUCE D. GELB, MARCO TARTAGLIA, LEN PENNACCHIO, SRINIVAS RAVI IYENGAR, AVI MA'AYAN
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Publication number: 20100009361Abstract: Diagnostic and therapeutic applications for Noonan Syndrome are described. The diagnostic and therapeutic applications are based on certain mutations in a RAS-specific guanine nucleotide exchange factor gene SOS1 or its expression product. The diagnostic and therapeutic applications are also based on certain mutations in a serine/threonine protein kinase gene RAF1 or its expression product thereof. Also described are nucleotide sequences, amino acid sequences, probes, and primers related to RAF1 or SOS1, and variants thereof, as well as host cells expressing such variants.Type: ApplicationFiled: November 16, 2007Publication date: January 14, 2010Applicants: MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERS, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Bruce D. Gelb, Marco Tartaglia, Len Pennacchio
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Publication number: 20090181884Abstract: Methods and materials for studying the effects of a newly identified human gene, APOAV, and the corresponding mouse gene apoAV. The sequences of the genes are given, and transgenic animals which either contain the gene or have the endogenous gene knocked out are described. In addition, single nucleotide polymorphisms (SNPs) in the gene are described and characterized. It is demonstrated that certain SNPs are associated with diseases involving lipids and triglycerides and other metabolic diseases. These SNPs may be used alone or with SNPs from other genes to study individual risk factors. Methods for intervention in lipid diseases, including the screening of drugs to treat lipid-related or diabetic diseases are also disclosed.Type: ApplicationFiled: May 29, 2007Publication date: July 16, 2009Applicant: The Regents of the University of CaliforniaInventors: Edward Rubin, Len A. Pennacchio
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Patent number: 7238475Abstract: Methods and materials for studying the effects of a newly identified human gene, APOAV, and the corresponding mouse gene apoAV. The sequences of the genes are given, and transgenic animals which either contain the gene or have the endogenous gene knocked out are described. In addition, single nucleotide polymorphisms (SNPs) in the gene are described and characterized. It is demonstrated that certain SNPs are associated with diseases involving lipids and triglycerides and other metabolic diseases. These SNPs may be used alone or with SNPs from other genes to study individual risk factors. Methods for intervention in lipid diseases, including the screening of drugs to treat lipid-related or diabetic diseases are also disclosed.Type: GrantFiled: August 27, 2002Date of Patent: July 3, 2007Assignee: The Regents of The University of CaliforniaInventors: Edward Rubin, Len A. Pennacchio
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Publication number: 20030150003Abstract: Methods and materials for studying the effects of a newly identified human gene, APOAV, and the corresponding mouse gene apoAV. The sequences of the genes are given, and transgenic animals which either contain the gene or have the endogenous gene knocked out are described. In addition, single nucleotide polymorphisms (SNPs) in the gene are described and characterized. It is demonstrated that certain SNPs are associated with diseases involving lipids and triglycerides and other metabolic diseases. These SNPs may be used alone or with SNPs from other genes to study individual risk factors. Methods for intervention in lipid diseases, including the screening of drugs to treat lipid-related or diabetic diseases are also disclosed.Type: ApplicationFiled: August 27, 2002Publication date: August 7, 2003Inventors: Edward Rubin, Len A. Pennacchio
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Patent number: 6432635Abstract: An isolated nucleic acid molecule, wherein the molecule contains: (1) a first sequence consisting of human cystatin B genomic DNA as set forth in FIG. 3 (SEQ ID NO:1); (2) a second sequence, wherein said second sequence is a subsequence of said first sequence, is at least nucleotides in length, and is not present in human cystatin B cDNA; (3) a third sequence in which at least one nucleotide of said first or second sequences is replaced by a different nucleotide; or (4) a fourth sequence complementary to any of said first, second or third sequences; with the proviso that (I) if said molecule is an RNA molecule, U replaces T in said sequence of said molecule, and (ii) said third sequence is at least 95% identical to said first or second sequence.Type: GrantFiled: March 18, 1997Date of Patent: August 13, 2002Assignees: Helsinki University Licensing Ltd. Oy, The Board of Trustees of the Leland Stanford Jr. UniveristyInventors: Richard M. Myers, David R. Cox, Len A. Pennacchio, Anna-Elina Lehesjoki, Albert De La Chapelle