Patents by Inventor Len Rybak

Len Rybak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF TRANSPLATIN TO PREVENT HEARING LOSS
    Publication number: 20160058791
    Abstract: Methods and compositions for treating and preventing toxic side effects of platinum-based chemotherapy agents are disclosed, in which transplatin is administered to a subject. Transplatin is shown to have protective effects against cisplatin-induced ototoxicity, nephotoxicity and neurotoxicity. Anti-inflammatory activity of transplatin is demonstrated and methods and compositions for treating and preventing inflammatory pain are described.
    Type: Application
    Filed: November 3, 2015
    Publication date: March 3, 2016
    Inventors: Vickram Ramkumar, Debashree Mukherjea, Len Rybak
  • Use of transplatin to prevent hearing loss
    Patent number: 9248150
    Abstract: Methods and compositions for treating and preventing toxic side effects of platinum-based chemotherapy agents are disclosed, in which transplatin is administered to a subject. Transplatin is shown to have protective effects against cisplatin-induced ototoxicity, nephotoxicity and neurotoxicity. Anti-inflammatory activity of transplatin is demonstrated and methods and compositions for treating and preventing inflammatory pain are described.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: February 2, 2016
    Assignee: The Board of Trustees of the Southern Illinois University
    Inventors: Vickram Ramkumar, Debashree Mukherjea, Len Rybak
  • USE OF TRANSPLATIN TO PREVENT HEARING LOSS
    Publication number: 20140087006
    Abstract: Methods and compositions for treating and preventing toxic side effects of platinum-based chemotherapy agents are disclosed, in which transplatin is administered to a subject. Transplatin is shown to have protective effects against cisplatin-induced ototoxicity, nephotoxicity and neurotoxicity. Anti-inflammatory activity of transplatin is demonstrated and methods and compositions for treating and preventing inflammatory pain are described.
    Type: Application
    Filed: December 3, 2013
    Publication date: March 27, 2014
    Applicant: Board of Trustees of Southern Illinois University
    Inventors: Vickram Ramkumar, Debashree Mukherjea, Len Rybak
  • Use of transplatin to prevent hearing loss
    Patent number: 8648114
    Abstract: Methods and compositions for treating and preventing toxic side effects of platinum-based chemotherapy agents are disclosed, in which transplatin is administered to a subject. Transplatin is shown to have protective effects against cisplatin-induced ototoxicity, nephotoxicity and neurotoxicity. Anti-inflammatory activity of transplatin is demonstrated and methods and compositions for treating and preventing inflammatory pain are described.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: February 11, 2014
    Assignee: The Board of Trustees of the Southern Illinois University
    Inventors: Vickram Ramkumar, Debashree Mukherjea, Len Rybak
  • METHODS FOR TREATMENT AND PREVENTION OF OTOTOXICITY BY siRNA
    Publication number: 20110160279
    Abstract: The present invention relates to methods for reducing and/or preventing ototoxicity caused by an ototoxic agent, noise or head and/or neck radiation. It is also directed to a method for preventing or reducing generation of reactive oxygen species in the inner ear of a patient. The methods of the present invention include administering at least one siRNA directed against TRPV1 mRNA, NOX3 mRNA or a combination thereof.
    Type: Application
    Filed: August 13, 2007
    Publication date: June 30, 2011
    Applicant: BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY
    Inventors: Vickram Ramkumar, Debashree Mukherjea, Len Rybak
  • USE OF TRANSPLATIN TO PREVENT HEARING LOSS
    Publication number: 20110014302
    Abstract: Methods and compositions for treating and preventing toxic side effects of platinum-based chemotherapy agents are disclosed, in which transplatin is administered to a subject. Transplatin is shown to have protective effects against cisplatin-induced ototoxicity, nephotoxicity and neurotoxicity. Anti-inflammatory activity of transplatin is demonstrated and methods and compositions for treating and preventing inflammatory pain are described.
    Type: Application
    Filed: July 14, 2010
    Publication date: January 20, 2011
    Applicant: BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY
    Inventors: Vickram Ramkumar, Debashree Mukherjea, Len Rybak