Abstract: The present invention relates to a system (10) and related method for planning a tomographic image acquisition of an object to be imaged by a tomographic imaging scanner (20). The system comprises an input (12) for receiving a 3D pre-scan image of the object and a camera system (14) for capturing 3D image information of the object. The system comprises a processor (16) for determining corresponding image features in the camera image and the pre-scan image. The processor determines an image transformation that relates the corresponding image features to each other, such that the object as represented by the pre-scan image can be transformed to the orientation, position and/or deformation of the object represented in the camera image. The processor plans the image acquisition, in which the pre-scan image is used to determine parameters including scan range. An output (18) outputs a signal representative of the determined plan.