Patent number: 8173774
Abstract: The present invention provides a polypeptide having a biological activity of the Chemotaxis Inhibitory Protein of Staphylococcus aureus (‘CHIPS’), the polypeptide comprising a variant of the amino acid sequence of SEQ ID NO:1. Preferably, the polypeptide is a CHIPS variant wherein one or more of the following amino acids is modified: N31, S32, G33, L34, P35, K40, D42, R46, Y48, K50, G52, T53, K54, N55, S56, A57, Q58, K61, E67, K69, L76, N77, P79, D83, L90, K92, K100, K101, S104, K105, S107, Y108, N111 and G112. In a preferred embodiment, the polypeptide is less immunogenic hi humans than the wildtype CHIPS protein. The invention further provides methods of making and using such variant CHIPS polypeptides.
Type:
Grant
Filed:
April 20, 2007
Date of Patent:
May 8, 2012
Assignee:
Alligator Bioscience AB
Inventors:
Christina Furebring, Johannes A. G. Van Strijp, Petrus J. A. Haas, Anna Rosen, Karin Haraldsson, Erika Gustafsson, Lena Schultz, Cornelis P. M. Van Kessel
Publication number: 20100298539
Abstract: The present invention provides a polypeptide having a biological activity of the Chemotaxis Inhibitory Protein of Staphylococcus aureus (‘CHIPS’), the polypeptide comprising a variant of the amino acid sequence of SEQ ID NO:1. Preferably, the polypeptide is a CHIPS variant wherein one or more of the following amino acids is modified: N31, S32, G33, L34, P35, K40, D42, R46, Y48, K50, G52, T53, K54, N55, S56, A57, Q58, K61, E67, K69, L76, N77, P79, D83, L90, K92, K100, K101, S104, K105, S107, Y108, N111 and G112. In a preferred embodiment, the polypeptide is less immunogenic hi humans than the wildtype CHIPS protein. The invention further provides methods of making and using such variant CHIPS polypeptides.
Type:
Application
Filed:
April 20, 2007
Publication date:
November 25, 2010
Inventors:
Christina Furebring, Johannes A.G. Van Strijp, Petrus J.A. Haas, Anna Rosen, Karin Haraldsson, Erika Gustafsson, Lena Schultz, Cornelis P.M. Van Kessel
