Patents by Inventor Lendon G. Payne

Lendon G. Payne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA-vaccines based on constructs derived from the genomes of human and animal pathogens
    Patent number: 7196066
    Abstract: Methods of eliciting an immune response in a subject by administering one or more large genomic DNA fragments are provided. Also provided are methods of identifying sequences encoding antigenic polypeptides. Also provided are vaccine compositions comprising one or more large genomic DNA fragments.
    Type: Grant
    Filed: November 1, 2000
    Date of Patent: March 27, 2007
    Assignee: Powderject Vaccines, Inc.
    Inventors: William F. Swain, Lee K. Roberts, Lendon G. Payne, Ralph P. Braun
  • Nucleic acid immunization
    Publication number: 20020165176
    Abstract: Recombinant nucleic acid molecules are described. The molecules have a sequence or sequences encoding an influenza virus M2 antigen. Vectors and compositions containing these molecules are also described. Methods for eliciting an immune response using these molecules and compositions are also described.
    Type: Application
    Filed: April 30, 2001
    Publication date: November 7, 2002
    Inventors: Joel R. Haynes, Michael D. Macklin, Lendon G. Payne
  • Polyphosphazene microspheres
    Patent number: 6207171
    Abstract: A soluble polyphosphazene polyelectrolyte immunoadjuvant is disclosed. In one embodiment, the polymeric adjuvant is poly[di(carboxylatrophenoxy)phosphazene] which is in the form of a microsphere and which is adsorbed with antigen after formation of the microsphere. The immunoadjuvant can be administered intranasally.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: March 27, 2001
    Assignee: Avant Immunotherapeutics, Inc.
    Inventors: Lendon G. Payne, Angela L. Woods, Sharon A. Jenkins
  • Polyphosphazene polyelectrolyte immunoadjuvants
    Patent number: 6015563
    Abstract: A polyphosphazene polyelectrolyte immunoadjuvant having improved water solubility, a vaccine composition of the immunoadjuvant and an antigen or immunogen and methods of their use in producing or enhancing an immunoprotective response in a host are disclosed.
    Type: Grant
    Filed: November 4, 1998
    Date of Patent: January 18, 2000
    Assignee: AVANT Immunotherapeutics, Inc.
    Inventors: Alexander K. Andrianov, Lendon G. Payne, Jonathan R. Sargent, Sameer S. Sule
  • Polyphosphazene polyelectrolyte immunoadjuvants
    Patent number: 5855895
    Abstract: A polyphosphazene polyelectrolyte immunoadjuvant having improved water solubility, a vaccine composition of the immunoadjuvant and an antigen or immunogen and methods of their use in producing or enhancing an immunoprotective response in a host are disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 5, 1999
    Assignee: Virus Research Institute
    Inventors: Alexander K. Andrianov, Lendon G. Payne, Jonathan R. Sargent, Sameer S. Sule
  • Hydrogel microencapsulated vaccines
    Patent number: 5529777
    Abstract: Water soluble polymers or polymeric hydrogels are used to encapsulate antigen to form vaccines. The antigen is mixed with a polymer solution, microparticles are formed of the polymer and antigen, and, optionally, the polymer is crosslinked to form a stable microparticle. Preferred polymers are alginate and polyphosphazenes, and mixtures thereof. Microparticles can be adminstered parenterally or mucosally. For oral delivery, the microparticles are preferably fifteen microns or less in diameter, and adhere to the mucosal lining of the gastrointestinal tract, increasing uptake by the reticuloendothelium.
    Type: Grant
    Filed: November 4, 1993
    Date of Patent: June 25, 1996
    Assignee: Virus Research Institute
    Inventors: Alexander K. Andrianov, Sharon A. Jenkins, Lendon G. Payne, Bryan E. Roberts
  • Phosphazene polyelectrolytes as immunoadjuvants
    Patent number: 5494673
    Abstract: An immunoadjuvant soluble polyphosphazene polyelectrolyte is disclosed. In one embodiment, the polymeric adjuvant is an poly(organophosphazene) with (i) ionized or ionizable pendant groups that contain, for example, carboxylic acid, sulfonic acid, or hydroxyl moieties, and (ii) pendant groups that are susceptible to hydrolysis under the conditions of use, to impart biodegradability to the polymer.
    Type: Grant
    Filed: July 11, 1994
    Date of Patent: February 27, 1996
    Assignee: Virus Research Institute
    Inventors: Alexander K. Andrianov, Sharon A. Jenkins, Lendon G. Payne, Bryan E. Roberts