Patents by Inventor Lendon N. Pridgen

Lendon N. Pridgen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing 1-alkyaryl-2-alkyl-5-formylimidazole
    Patent number: 5565577
    Abstract: This invention relates to a process for preparing 1-alkylaryl-2-alkyl-5-formylimidazoles of the formula (I): ##STR1## which are useful intermediates in the preparation of 1,2,5-substituted imidazoles having angiotensin II receptor antagonist activity.
    Type: Grant
    Filed: March 22, 1995
    Date of Patent: October 15, 1996
    Assignee: SmithKline Beecham Corporation
    Inventors: Mohamed K. Mokhallalati, Lendon N. Pridgen, Susan Shilcrat, Joseph Weinstock
  • Compounds for preparing 6-phenyl-2,3-dihydroimidazo[2,1-b]-thiazoles and corresponding thiazines
    Patent number: 5008390
    Abstract: 6-Aryl-2,3-dihydroimidazo[2,1-b]thiazoles and corresponding thiazines act as nucleophiles, either directly or in the form of Grignard reagents, with N-acylpyridinium salts to produce new 6-aryl-5-(N-acyl-1,4-dihydro-4-pyridyl)-2,3-dihydroimidazo-[2,1-b]thiazole s and corresponding thiazines. These are oxidized to give the corresponding pyridyl-substituted imidazo[2,1-b]thiazoles and thiazines, which are active as inhibitors of the 5-lipoxygenase pathway of arachidonic acid metabolism.
    Type: Grant
    Filed: November 3, 1988
    Date of Patent: April 16, 1991
    Assignee: SmithKline Beckman Corporation
    Inventors: Paul E. Bender, Ivan Lantos, Michael A. McGuire, Lendon N. Pridgen, Herbert B. Winicov
  • 1.4-dihydro-4-pyridyl-substituted imidazo (2,1-b) thiazoles and the corresponding thiazines.
    Patent number: 4803279
    Abstract: 6-Aryl-2,3-dihydroimidazo[2,1-b]thiazoles and corresponding thiazines act as nucleophiles, either directly or in the form of Grignard reagents, with N-acylpyridinium salts to produce new 6-aryl-5-(N-acyl-1,4-dihydro-4-pyridyl)-2,3-dihydroimidazo-[2,1-b]thiazole s and corresponding thiazines. These are oxidized to give the corresponding pyridyl-substituted imidazo[2,1-b]thiazoles and thiazines, which are active as inhibitors of the 5-lipoxygenase pathway of arachidonic acid metabolism.
    Type: Grant
    Filed: April 28, 1986
    Date of Patent: February 7, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Paul E. Bender, Ivan Lantos, Michael A. McGuire, Lendon N. Pridgen, Herbert B. Winicov
  • Substituted pyrimidinones
    Patent number: 4675406
    Abstract: This invention relates to substituted 4-pyrimidinones which are useful as intermediates in preparing H.sub.2 -antagonists.
    Type: Grant
    Filed: January 13, 1986
    Date of Patent: June 23, 1987
    Assignee: SmithKline Beckman Corporation
    Inventors: Bing L. Lam, Lendon N. Pridgen
  • Chemical methods and intermediates for preparing substituted pyrimidinones
    Patent number: 4620001
    Abstract: A series of chemical reactions starting from the condensation of uracil with an acid stable heterocyclic aldehyde in an acid medium produces biologically active end products which are 2-heterocyclylmethylthioethylamino-5-heterocyclylmethyl-4-pyrimidinones. The new reactions and intermediates of this invention are particularly useful for preparing 2[2-(5-dimethylaminomethyl-2-furylmethylthio)-ethylamino]-5-(6-methyl-3-py ridylmethyl)-4-pyrimidinone and its salts. This compound is a potent H.sub.2 -antagonist with a long duration of activity.
    Type: Grant
    Filed: September 11, 1984
    Date of Patent: October 28, 1986
    Assignee: SmithKline Beckman Corporation
    Inventors: Bing L. Lam, Lendon N. Pridgen
  • Intermediates for preparing substituted pyrimidinones
    Patent number: 4477663
    Abstract: A series of chemical reactions starting from the condensation of uracil with an acid stable heterocyclic aldehyde in an acid medium produces biologically active end products which are 2-heterocyclylmethylthioethylamino-5-heterocyclylmethyl-4-pyrimidinones. The new reactions and intermediates of this invention are particularly useful for preparing 2[2-(5-dimethylaminomethyl-2-furylmethylthio)-ethylamino]-5-(6-methyl-3-py ridylmethyl)-4-pyrimidinone and its salts. This compound is a potent H.sub.2 -antagonist with a long duration of activity.
    Type: Grant
    Filed: April 7, 1982
    Date of Patent: October 16, 1984
    Assignee: SmithKline Beckman Corporation
    Inventors: Bing L. Lam, Lendon N. Pridgen
  • Novel heterocyclic compounds
    Patent number: 4428948
    Abstract: This invention relates to novel heterocyclic fungicides which are effective in controlling a broad spectrum of phytopathogenic fungi found in the four main classes of fungi namely Phycomycetes, Ascomycetes, Fungi Imperfecti, and Basidiomycetes. Certain of these compounds are especially effective in controlling sclerotial forming fungi such as Whetzelinia sclerotiorum=(Sclerotinia sclerotiorium) and Botrytis cinerea.
    Type: Grant
    Filed: February 3, 1977
    Date of Patent: January 31, 1984
    Assignee: Rohm and Haas Company
    Inventors: George A. Miller, Lendon N. Pridgen
  • Novel heterocyclic compounds
    Patent number: 4378357
    Abstract: This invention relates to novel heterocyclic fungicides which are effective in controlling a broad spectrum of phytopathogenic fungi found in the four main classes of fungi namely Phycomycetes, Ascomycetes, Fungi Imperfecti, and Basidiomycetes. Certain of these compounds are especially effective in controlling sclerotial forming fungi such as Whetzelinia sclerotiorum=(Sclerotinia sclerotiorium) and Botrytis cinerea.
    Type: Grant
    Filed: December 16, 1977
    Date of Patent: March 29, 1983
    Assignee: Rohm and Haas Company
    Inventors: George A. Miller, Lendon N. Pridgen
  • Chemical methods and intermediates for preparing substituted pyrimidinones
    Patent number: 4352933
    Abstract: A series of chemical reactions starting from the condensation of uracil with an acid stable heterocyclic aldehyde in an acid medium produces biologically active end products which are 2-heterocyclylmethylthioethylamino-5-heterocyclylmethyl-4-pyrimidinones. The new reactions and intermediates of this invention are particularly useful for preparing 2[2-(5-dimethylaminomethyl-2-furylmethylthio)-ethylamino]-5-(6-methyl-3-py ridylmethyl)-4-pyrimidinone and its salts. This compound is a potent H.sub.2 -antagonist with a long duration of activity.
    Type: Grant
    Filed: February 6, 1981
    Date of Patent: October 5, 1982
    Assignee: Smithkline Beckman Corporation
    Inventors: Bing L. Lam, Lendon N. Pridgen