Patents by Inventor Lene Feldskov Nielsen
Lene Feldskov Nielsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11911310Abstract: An adhesive wafer for an ostomy device, the wafer comprising a skin-facing adhesive layer, a backing layer on the non-skin-facing side of the adhesive layer, and a hole for accommodating a stoma. On the central portion of the backing layer is located a release layer being configured to release a neutralizer. The neutralizer is capable of neutralizing or at least minimizing the level of skin or adhesive aggressiveness of the output.Type: GrantFiled: November 2, 2018Date of Patent: February 27, 2024Assignee: Coloplast A/SInventors: Lene Feldskov Nielsen, Monica Ramos Gallego
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Publication number: 20210177641Abstract: An adhesive wafer for an ostomy device, the wafer comprising a skin-facing adhesive layer, a backing layer on the non-skin-facing side of the adhesive layer, and a hole for accommodating a stoma. On the central portion of the backing layer is located a release layer being configured to release a neutralizer. The neutralizer is capable of neutralizing or at least minimizing the level of skin or adhesive aggressiveness of the output.Type: ApplicationFiled: November 2, 2018Publication date: June 17, 2021Inventors: Lene Feldskov Nielsen, Monica Ramos Gallego
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Patent number: 10123908Abstract: The present invention relates to method of preparing an absorbent wound care device comprising an active agent on a wound contacting surface, such as e.g. a protein or an enzyme, by the use of electrospraying, and a wound care device obtained by said method. The invention further relates to a wound care device comprising Thrombin and a polyurethane foam, and a method of treating bleeding.Type: GrantFiled: July 10, 2012Date of Patent: November 13, 2018Assignee: Coloplast A/SInventors: Hanne Everland, Kurt Osther, Jacob Vange, Lene Feldskov Nielsen
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Patent number: 9636438Abstract: The present invention relates to a temporary composite scaffold comprising discrete ECM particles formed as a fistula plug. We demonstrate that when using scaffolds containing ECM material, higher concentrations of ECM surprisingly do not give better cell morphology. Concentrations lower than 60% (w/w) are sufficient to obtain the best cell morphology and distribution.Type: GrantFiled: March 7, 2008Date of Patent: May 2, 2017Assignee: Coloplast A/SInventors: Lene Feldskov Nielsen, Jens Hoeg Truelsen, Hanne Everland
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Patent number: 9295762Abstract: The present application discloses that incorporation of dermatan sulfate and/or HA in composite scaffolds of certain polymers gives rise to a chondrogenic effect on chondrocytes resulting in formation of cartilage that resembles the natural ECM. This effect with dermatan sulfate as the primary additive has not previously been seen. The composites are formed by incorporation of dermatan sulfate finely dispersed particles optionally nanoparticles or as molecular dissolutions in a polymer matrix with no bonding between the DS and the matrix, providing the DS to the chondrocytes in an accessible non-crosslinked form.Type: GrantFiled: March 7, 2008Date of Patent: March 29, 2016Assignee: Coloplast A/SInventors: Hanne Everland, Jacob Vange, Christian Clausen, Lene Feldskov Nielsen
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Patent number: 9066812Abstract: An ostomy device that comprises an adhesive wafer for attaching to the skin around the stoma. The wafer comprises an adhesive layer having a proximal adhesive surface and a distal surface. The distal surface is covered with a backing layer. The wafer comprises a central portion and a peripheral portion, and it comprises at least a first and a detection zone, wherein the detection zone is configured to provide a tactile sensation on the distal surface of the wafer when exposed to moisture.Type: GrantFiled: June 22, 2010Date of Patent: June 30, 2015Assignee: Coloplast A/SInventors: Henrik Edvardsen, Michael Hansen, Danuta Ciok, Lene Feldskov Nielsen, Kent Hoeier Nielsen
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Patent number: 8877223Abstract: The present application discloses biodegradable polymers, to porous and other materials comprising such polymers, and to various medical uses of such materials, including use as a scaffold for supporting cell adhesion or the in-growth for regeneration of tissue. The polymer is of the formula A-O—(CHR1CHR2O)n—B wherein A is a poly(lactide-co-glycolide) residue, the molar ratio of (i) lactide units [—CH(CH3)—COO—] and (ii) glycolide units [—CH2—COO—] in the poly(lactide-co-glycolide) residue being in the range of 80:20 to 10:90, B is either a poly(lactide-co-glycolide) residue or hydrogen, C1-6-alkyl or hydroxy protecting groups, one of R1 and R2 is hydrogen or methyl, and the other is hydrogen, n is 10-1000, the molar ratio of (iii) polyalkylene glycol units [—(CHR1CHR2O)—] to the combined amount of (i) lactide units and (ii) glycolide units in the poly(lactide-co-glycolide) residue(s) is at the most 14:86, and the molecular weight of the copolymer is at least 20,000 g/mol.Type: GrantFiled: March 7, 2007Date of Patent: November 4, 2014Assignee: Coloplast A/SInventors: Jakob Vange, Khadija Schwach-Abdellaoui, Hanne Everland, Peter Sylvest Nielsen, Brian Nielsen, Lene Karin Jespersen, Lene Feldskov Nielsen
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Publication number: 20140248420Abstract: The present invention relates to method of preparing an absorbent wound care device comprising an active agent on a wound contacting surface, such as e.g. a protein or an enzyme, by the use of electrospraying, and a wound care device obtained by said method. The invention further relates to a wound care device comprising Thrombin and a polyurethane foam, and a method of treating bleeding.Type: ApplicationFiled: July 10, 2012Publication date: September 4, 2014Applicant: Coloplast A/SInventors: Hanne Everland, Kurt Osther, Jacob Vange, Lene Feldskov Nielsen
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Patent number: 8409158Abstract: An ostomy device that comprises an adhesive wafer for attaching to the skin around the stoma. The wafer comprises an adhesive layer having a proximal adhesive side and a distal side, where the distal side is covered with a backing layer. The wafer comprises a central portion and a peripheral portion, and it comprises a proximal section located on the proximal side of the central portion and a distal section visually arranged on the distal side of peripheral portion, wherein the distal section changes colour when the proximal section is exposed to fluid.Type: GrantFiled: June 22, 2010Date of Patent: April 2, 2013Assignee: Coloplast A/SInventors: Henrik Edvardsen, Michael Hansen, Danuta Ciok, Lene Feldskov Nielsen, Kent Hoeier Nielsen
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Publication number: 20120165957Abstract: The present invention relates to new reinforced biodegradable scaffolds for soft tissue regeneration, as well as methods for support and for augmentation and regeneration of living tissue, wherein a reinforced biodegradable scaffold is used for the treatment of indications, where increased strength and stability is required besides the need for regeneration of living tissue within a patient. The present invention further relates to the use of scaffolds together with cells or tissue explants for soft tissue regeneration, such as in the treatment of a medical prolapse, such as rectal or pelvic organ prolapse, or hernia.Type: ApplicationFiled: July 6, 2010Publication date: June 28, 2012Inventors: Hanne Everland, Lene Feldskov Nielsen, Jakob Vange, Monica Ramos Gallego
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Publication number: 20120143155Abstract: An ostomy device that comprises an adhesive wafer for attaching to the skin around the stoma. The wafer comprises an adhesive layer having a proximal adhesive side and a distal side, where the distal side is covered with a backing layer. The wafer comprises a central portion and a peripheral portion, and it comprises a proximal section located on the proximal side of the central portion and a distal section visually arranged on the distal side of peripheral portion, wherein the distal section changes colour when the proximal section is exposed to fluid.Type: ApplicationFiled: June 22, 2010Publication date: June 7, 2012Applicant: COLOPLAST A/SInventors: Henrik Edvardsen, Michael Hansen, Danuta Ciok, Lene Feldskov Nielsen, Kent Hoeier Nielsen
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Publication number: 20120143154Abstract: An ostomy device that comprises an adhesive wafer for attaching to the skin around the stoma. The wafer comprises an adhesive layer having a proximal adhesive surface and a distal surface. The distal surface is covered with a backing layer. The wafer comprises a central portion and a peripheral portion, and it comprises at least a first and a detection zone, wherein the detection zone is configured to provide a tactile sensation on the distal surface of the wafer when exposed to moisture.Type: ApplicationFiled: June 22, 2010Publication date: June 7, 2012Applicant: COLOPLAST A/SInventors: Henrik Edvardsen, Michael Hansen, Danuta Ciok, Lene Feldskov Nielsen, Kent Hoeier Nielsen
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Patent number: 8053559Abstract: We add discontinuous regions of Extra Cellular Matrix (ECM) to a biodegradable scaffold. Hereby it is possible to combine the range of physical properties the scaffold can offer with the reconstructive properties of the ECM. The optimal amount of discrete ECM material for each application is disclosed and this concentration is equally distributed in the dressing hence avoiding unnecessary high concentrations of ECM. In addition to the effect of the ECM, the porous structure of the base material provides the cells with a structure for in-growth.Type: GrantFiled: October 26, 2006Date of Patent: November 8, 2011Assignee: Coloplast A/SInventors: Peter Sylvest Nielsen, Brian Nielsen, Lene Karin Jespersen, Hanne Everland, Lene Feldskov Nielsen
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Publication number: 20100086578Abstract: The present invention relates to a temporary composite scaffold comprising discrete ECM particles formed as a fistula plug. We demonstrate that when using scaffolds containing ECM material, higher concentrations of ECM surprisingly do not give better cell morphology. Concentrations lower than 60% (w/w) are sufficient to obtain the best cell morphology and distribution.Type: ApplicationFiled: March 7, 2008Publication date: April 8, 2010Inventors: Lene Feldskov Nielsen, Jens Hoeg Truelsen, Hanne Everland
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Publication number: 20100087839Abstract: The present application discloses that incorporation of dermatan sulfate and/or HA in composite scaffolds of certain polymers gives rise to a chondrogenic effect on chondrocytes resulting in formation of cartilage that resembles the natural ECM. This effect with dermatan sulfate as the primary additive has not previously been seen. The composites are formed by incorporation of dermatan sulfate finely dispersed particles optionally nanoparticles or as molecular dissolutions in a polymer matrix with no bonding between the DS and the matrix, providing the DS to the chondrocytes in an accessible non-crosslinked form.Type: ApplicationFiled: March 7, 2008Publication date: April 8, 2010Inventors: Lene Feldskov Nielsen, Jens Truelsen, Hanne Everland
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Publication number: 20090280154Abstract: We add discontinuous regions of Extra Cellular Matrix (ECM) to a biodegradable scaffold. Hereby it is possible to combine the range of physical properties the scaffold can offer with the reconstructive properties of the ECM. The optimal amount of discrete ECM material for each application is disclosed and this concentration is equally distributed in the dressing hence avoiding unnecessary high concentrations of ECM. In addition to the effect of the ECM, the porous structure of the base material provides the cells with a structure for in-growth.Type: ApplicationFiled: October 26, 2006Publication date: November 12, 2009Inventors: Peter Sylvest Nielsen, Brian Nielsen, Lene Karin Jespersen, Hanne Everland, Lene Feldskov Nielsen
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Publication number: 20090047322Abstract: The present application discloses biodegradable polymers, to porous and other materials comprising such polymers, and to various medical uses of such materials, including use as a scaffold for supporting cell adhesion or the in-growth for regeneration of tissue. The polymer is of the formula A—O—(CHR1CHR2O)n-B wherein A is a poly(lactide-co-glycolide) residue, the molar ratio of (i) lactide units [—CH(CH3)—COO—] and (ii) glycolide units [—CH2—COO—] in the poly(lactide-co-glycolide) residue being in the range of 80:20 to 10:90, B is either a poly(lactide-co-glycolide) residue or hydrogen, C1-6-alkyl or hydroxy protecting groups, one of R1 and R2 is hydrogen or methyl, and the other is hydrogen, n is 10-1000, the molar ratio of (iii) polyalkylene glycol units [-(CHR1CHR2O)—] to the combined amount of (i) lactide units and (ii) glycolide units in the poly(lactide-co-glycolide) residue(s) is at the most 14:86, and the molecular weight of the copolymer is at least 20,000 g/mol.Type: ApplicationFiled: March 7, 2007Publication date: February 19, 2009Inventors: Jakob Vange, Khadija Schwach-Abdellaoui, Hanne Everland, Peter Sylvest Nielsen, Brian Nielsen, Lene Karin Jespersen, Lene Feldskov Nielsen