Abstract: A device for binding and separation of at least one component from a body fluid is disclosed. The device may have a proximal end and a distal end. The device may include a housing, an inlet disposed at the proximal end, an outlet, at least one of a sheet and a disc of a first matrix for binding of a first component from the body fluid, and a plurality of beads of a second matrix for binding of a second component from the body fluid. The first matrix may have a porous structure. The first component and the second component may be one of the same and different.

Abstract: A matrix for selective binding of at least one component from a body fluid. The matrix may include a porous structure, a linker, a peptide covalently attached via the linker, and a coating of a polyalcohol.