Abstract: The present invention relates to a hemostatic absorbable composition, comprising: a flowable plurality of separate aggregates each comprising: a plurality of absorbable carrier particles coated on a surface thereof by a plurality of smaller particles comprising an absorbable supplemental hemostasis-promoting agent. In some embodiments, the absorbable carrier particles comprise gelatin or collagen, and the supplemental hemostasis-promoting agent comprises oxidized cellulose, oxidized regenerated cellulose, carboxylic oxidized cellulose, carboxylic oxidized regenerated cellulose, thrombin, or tranexamic acid.

Abstract: A reinforcing incision drape for tissue, such as fragile tissue, includes an absorbable surgical mesh having top and bottom major surfaces. The absorbable surgical mesh has a stitching zone and first and second reinforcing zones that bound opposite sides of the stitching zone. The stitching zone is less porous and the first and second reinforcing zones are more porous than the stitching zone. A releasable liner covers the top major surface of the absorbable surgical mesh within the stitching zone of the absorbable surgical mesh. A weaker adhesive, such as a pressure sensitive adhesive, covers the bottom major surface of the surgical mesh within the centrally located stitching zone of the absorbable surgical mesh, and a stronger adhesive, such as cyanoacrylite, covers the first and second reinforcing zones of the absorbable surgical mesh.

Abstract: A skin closure system includes a surgical mesh, a topical skin adhesive, and a strip that may be secured relative to the surgical mesh. The surgical mesh includes an upper side and a lower side, with the lower side capable of adhering to a section of the patient skin that surrounds a wound. The topical skin adhesive can be applied to the upper side of the surgical mesh and cure within the surgical mesh to form a protective layer over the wound. The strip has an elongated body impregnated with an active pharmaceutical ingredient. The strip extends longitudinally along a central portion of the lower side of the elongated mesh and can diffuse the active pharmaceutical integrated toward the wound after the protective layer is formed over the wound.

Abstract: A skin closure system includes a surgical mesh dimensioned to surround a wound, a topical skin adhesive that may be applied to an upper side of the surgical mesh to thereby form a protective layer over the wound, and a sensate located on a peripheral area of the surgical mesh such that the senate is spaced a distance away from the wound.

Abstract: The present invention is directed to a sealant patch for use on or over sensitive tissue, comprising: a flat, flexible, bioresorbable substrate coated by a moisture-activated adhesive on one side thereof, wherein said adhesive is at least partially inactivated in a first portion of said patch, but remains active in peripheral areas surrounding the first portion. The adherence of the first portion to the tissue is weaker versus adherence in the peripheral areas. The adhesive in the first portion is fully or partially inactivated or pre-reacted prior to application of the sealant patch to the tissue.

Abstract: The present invention is directed to a length adaptive surgical suture comprising a monofilament or a braid of a plurality of filaments, the suture having an original length when implanted and a second length that is different from the original length within a first twenty-four (24) hour period of time after implantation to accommodate tissue swelling. The present invention is also directed to configurations and combinations that enable length adaptive results.

Abstract: An implant delivery sleeve comprises a tubular wall having a proximal end with a proximal opening, a distal end with a distal opening, and an implant delivery channel extending between the proximal and distal ends of said tubular wall. A plurality of bands interconnect portions of the tubular wall for constricting the implant delivery channel adjacent the distal end of the tubular wall. As an implant is advanced toward the distal end of the tubular wall, the constriction squeezes and/or deforms the implant for facilitating insertion into an incision that is smaller than the normal size of the implant.

Abstract: A reconfigurable suture needle includes an elongated body having a curved proximal section and a curved distal section. The curved proximal section is hollow and includes an elongated conduit extending from a proximal end to a distal end thereof. The curved distal section includes a needle point at a distal end thereof and a hollow post projecting proximally from a proximal end thereof. A suture thread passes through the elongated conduit of the curved proximal section and has a distal end that passes through the hollow post of the curved distal section for being secured to the proximal end of the curved distal section.

Abstract: An apparatus includes a cannular defining a lumen and a wound closure device. The cannula can couple with a suction source to establish fluid communication between the suction source and the lumen. The cannula includes a distal portion defining at least one aperture such that the at least one aperture is in fluid communication with the lumen and an exterior surface of the distal portion. The wound closure device can cover a wound in skin. The wound closure device can receive a layer of topical adhesive to adhere to the skin and form a microbial barrier over the wound. The wound closure device includes a cannula housing defining a channel that can receive a distal portion of the cannula. The cannula can be inserted within the cannula housing to provide fluid communication between the suction source and the wound after formation of the microbial barrier.

Abstract: An apparatus includes a cannula that can establish fluid communication with a suction source, and a wound closure path dimensioned to cover a wound in skin. The wound closure patch can receive a topical adhesive to adhere to the skin and form a microbial barrier over the wound. The wound closure patch defines a channel. The wound closure patch includes a top surface, a bottom surface defining at least one channel interposed between the top surface and the bottom surface, and a fluid coupling section in fluid communication with the channel. The fluid coupling section can couple with the cannula to thereby establish fluid communication between the cannula, the channel, and the at least one opening defined by the bottom surface.

Abstract: A single-armed suture assembly includes a needle, a flexible suture, and a flexible sheath. The flexible suture is coupled with the needle. The flexible suture includes first and second portions. The first portion includes a plurality of first barbs having first tips extending away from the longitudinal path in either an insertion direction or in a counter insertion direction that is opposite to the insertion direction. The second portion includes a plurality of second barbs having second tips extending opposite to the first tips. The flexible sheath is configured to prevent one of the first or second tips that extend in the insertion direction from contacting tissue as the flexible sheath is being advanced in the insertion direction. The other of the first or second tips that extend in the counter insertion direction is configured to contact tissue as the flexible sheath is being advanced in the insertion direction.

Abstract: A device for joining two layers of tissue, comprises a substantially flat and flexible scaffold having an upper surface, a lower surface and sidewalls; a plurality of first passages penetrating said scaffold from said upper surface to said lower surface; a plurality of second passages penetrating said scaffold from said upper surface to said lower surface; a substantially flat and flexible top cover releasably attached to said upper surface and covering all of said upper surface; said top cover having a plurality of top cover passages aligned with said first plurality of passages.

Abstract: A device for application onto incisions or wounds with a liquid rapidly polymerizable adhesive for forming skin closure systems, comprising a flat porous mesh elongated along a longitudinal axis and having an upper side and an opposing lower or wound facing side and a central portion in immediate vicinity of the axis; further having a plurality of pores and windows in said mesh, said windows substantially larger than said pores and arranged along said longitudinal axis in said central portion; a crosslinking or polymerization accelerator or initiator disposed in or on said mesh; and a pressure sensitive adhesive disposed on at least a portion of the lower surface of said mesh.

Abstract: A system or device for skin closure comprises an elastic flat flexible tape elongated along a longitudinal axis and having a lower side and an opposing upper side, said tape having a pressure sensitive adhesive on at least a portion of the lower side, said tape having a plurality of openings arranged side-by-side with spaces between said openings oriented across the longitudinal axis.

Abstract: The present invention is directed to a hemostatic semi-solid paste material comprising a bioabsorbable carrier hemostatic material; and a supplemental hemostatic agent; wherein the paste material has an elongated form extending along a lengthwise axis with an aspect ratio of at least 3; wherein the paste is self-supporting and syringe extrudable; and wherein the supplemental hemostatic agent has a non-homogenous distribution profile across a cross-section taken across the lengthwise axis. In another aspect, the present invention relates to devices for forming and expressing the hemostatic material.

Abstract: The present is directed to systems for ex vivo testing performance of a hemostatic or sealing product attached to an animal organ and fully covering a cored channel in said organ, comprising: a pressure sensor positioned proximate to said hemostatic or sealing product in said cored channel; a monitoring or recording device configured to receive pressure readings from said pressure sensor; and a pressurized fluid source connected to said cored channel and configured to supply said pressurized fluid into said cored channel under constant or variable pressure. The present invention is also directed to methods of use for such systems.

Abstract: A breast implant or tissue expander includes an implant shell having an inner chamber and a tube detachably connected with the implant shell. The tube has a first lumen that is in fluid communication with the inner chamber for adding fluid into the inner chamber to increase the size of said implant shell or for removing fluid from the inner chamber to reduce the size of the implant shell. The tube has a second lumen and one or more lateral openings in fluid communication with the second lumen for draining fluid that collects in tissue surrounding the implant shell. The breast implant has a fluid inlet opening formed in the implant shell, and a valve disposed within the fluid inlet opening. The valve is normally biased into a closed position, and is opened by inserting the distal end of the tube into the fluid inlet opening.

Abstract: A method of making an implantable prosthesis includes applying a gelling enhancer layer over an inner surface of a wall of a silicone shell having anterior and posterior walls surrounding an interior volume. The method includes filling the interior volume of the shell with a silicone gel and curing the silicone gel. The cured silicone gel that is located within a zone that is in the vicinity of the gelling enhancer layer has a higher level of cohesiveness than the cured silicone gel that is located outside the zone. The zone of the silicone gel having the higher level of cohesiveness has a thickness of 2-10 mm. The silicone gel located outside the zone has a first concentration level of a gelling enhancer and the silicone gel located within the zone has a second concentration level of the gelling enhancer that is 5%-300% greater than the first concentration level.

Abstract: An implantable device for control over the size of emphysematous bullae in a lung, including: an elongated central region having a fixed axial length; a first end including a first anchor; and a second end including a second anchor.

Abstract: The present invention is directed to a spray applicator for spraying a tissue treatment medicant onto a tissue that has a container containing the medicant and is positioned at a proximal end of the spray applicator; a spray tip positioned at a distal end of the spray applicator; a cannula connecting the container with the spray tip; an actuatable dispensing mechanism at a proximal end of the applicator to express the medicant from the container through the cannula and through the spray tip toward the tissue; an optional pressurized gas source discharging a gas through the cannula in the vicinity of the spray tip or inside the spray tip; and a distance indicator that provides indicia of the distance between the spray tip and the tissue but does not prevent positioning the spray tip closer to the tissue than a defined distance for the distance indicator.