Patents by Inventor Leo Backx

Leo Backx has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mtp inhibiting aryl piperydines or piperazines substituted with 5-membered heterocycles
    Publication number: 20070191383
    Abstract: The present invention is concerned with novel aryl piperidine or piperazine compounds substituted with certain 5-membered heterocycles having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hyper-triglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
    Type: Application
    Filed: March 7, 2005
    Publication date: August 16, 2007
    Inventors: Lieven Meerpoel, Leo Backx, Libuse Jaroskova, Peter Roevens, Louis Van Der Veken, Marcel Viellevoye, Joannes Linders
  • SULFONYL-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE
    Publication number: 20070142393
    Abstract: This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
    Type: Application
    Filed: January 30, 2007
    Publication date: June 21, 2007
    Inventors: Kristof Emelen, Janine Arts, Leo Backx, Hans De Winter, Sven Van Brandt, Marc Verdonck, Lieven Meerpoel, Isabelle Pilatte, Virginie Poncelet, Alexey Dyatkin, Jimmy Van heusden
  • POLYARYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS
    Publication number: 20070082888
    Abstract: Polyarylcarboxamide compounds of formula (I) are useful as lipid lowering agents.
    Type: Application
    Filed: October 20, 2006
    Publication date: April 12, 2007
    Inventors: LIEVEN Meerpoel, Peter Roevens, Leo Backx, Louis Van der Veken, Marcel Viellevoye
  • Polyarylcarboxamides useful as lipid lowering agents
    Publication number: 20060241113
    Abstract: Polyarylcarboxamide compounds of formula (I) are useful as lipid lowering agents.
    Type: Application
    Filed: June 26, 2006
    Publication date: October 26, 2006
    Inventors: Lieven Meerpoel, Peter Roevens, Leo Backx, Louis Van der Veken, Marcel Viellevoye
  • Biphenylcarboxamides useful as lipid lowering agents
    Publication number: 20060128972
    Abstract: Biphenylcarboxamide compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes.
    Type: Application
    Filed: January 24, 2006
    Publication date: June 15, 2006
    Inventors: Lieven Meerpoel, Leo Backx
  • N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion
    Publication number: 20060040989
    Abstract: N-aryl piperidine substituted biphenylcarboxamides compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes.
    Type: Application
    Filed: August 5, 2003
    Publication date: February 23, 2006
    Inventors: Lieven Meerpoel, Leo Backx, Peter Roevens
  • Sulfonylamino-derivatives as novel inhibitors of histone deacetylase
    Publication number: 20050171347
    Abstract: This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
    Type: Application
    Filed: March 11, 2003
    Publication date: August 4, 2005
    Inventors: Kristof Emelen, Leo Backx, Sven Van Brandt, Patrick Angibaud, Isabelle Noelle Pilatte, Marc Gustaaf Verdonck, Hans De Winter
  • Polyarylcarboxamides useful as lipid lowering agents
    Publication number: 20050159402
    Abstract: Polyarylcarboxamide compounds of formula (I) are useful as lipid lowering agents.
    Type: Application
    Filed: January 5, 2005
    Publication date: July 21, 2005
    Inventors: Lieven Meerpoel, Peter Roevens, Leo Backx, Louis Van der Veken, Marcel Viellevoye
  • Carbonylamino-derivatives as novel inhibitors of histone deacetylase
    Publication number: 20050148613
    Abstract: This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
    Type: Application
    Filed: March 11, 2003
    Publication date: July 7, 2005
    Inventors: Kristof Van Emelen, Marc Verdonck, Sven Franciscus Van Brandt, Leo Backx
  • Sulfonyl-Derivatives as novel inhibitors of histone deacetylase
    Publication number: 20050113373
    Abstract: This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
    Type: Application
    Filed: March 11, 2003
    Publication date: May 26, 2005
    Inventors: Kristof Van Emelen, Janine Arts, Leo Backx, Hans De Winter, Sven Van Brandt, Marc Verdonck, Lieven Meerpoel, Isabelle Pilatte, Virginie Poncelet, Alexey Dyatkin
  • 1-(2-aryl-1,3-dioxon-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles
    Patent number: 4939162
    Abstract: Novel 1-(2-aryl-1,3-dioxan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles wherein the 1,3-dioxane ring is optionally substituted with 1 to 3 substituents.
    Type: Grant
    Filed: February 24, 1989
    Date of Patent: July 3, 1990
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo Backx, Adolf Hubele
  • Fungicidal 1-(-2-aryl-4,5-disubstituted-1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles
    Patent number: 4602010
    Abstract: Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles wherein the 1,3-dioxolane ring is substituted in the 4- and in the 5-positions, said compounds having useful antimicrobial properties.
    Type: Grant
    Filed: November 7, 1983
    Date of Patent: July 22, 1986
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Leo Backx, Willy Van Laerhoven, Elmar Sturm
  • Substituted 1-(2-aryl-1,3-dioxolan-2-ylmethyl)-1H-1,2,4-triazoles
    Patent number: 4338327
    Abstract: Novel 1-(2-aryl-1,3-dioxolan-2-ylmethyl)-1H-1,2,4-triazoles wherein the 1,3-dioxolane ring is substituted in the 4-position which are useful for the protection of plants and plant products against fungal attack.
    Type: Grant
    Filed: June 29, 1979
    Date of Patent: July 6, 1982
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Leo Backx, Adolf Hubele, Robert Nyfeler
  • 1-(2-Aryl-4,5-disubstituted-1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles
    Patent number: 4329342
    Abstract: Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles wherein the 1,3-dioxolane ring is substituted in the 4- and in the 5-positions, said compounds having useful antimicrobial properties.
    Type: Grant
    Filed: November 3, 1980
    Date of Patent: May 11, 1982
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Leo Backx, Willy Van Laerhoven, Elmar Sturm