Patents by Inventor Leo Brizuela

Leo Brizuela has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adenylyl cyclases as novel targets for the treatment of infection by eukaryotic pathogens
    Patent number: 9095578
    Abstract: The present invention relates to a method of preventing or treating a disease caused by infection by a eukaryotic pathogen, wherein the method comprises administering an effective amount of a modulator of a eukaryotic pathogen's adenylyl cyclase. The invention also provides pharmaceutical compositions useful for preventing or treating a disease, with the compositions containing a therapeutically effective amount of a modulator of a eukaryotic pathogen's adenylyl cyclase. The invention also provides screening methods for identifying selective modulators of a eukaryotic pathogen's adenylyl cyclase that do not substantially modulate an adenylyl cyclase of the subject. The invention also provides methods for culturing eukaryotic pathogens and methods for inducing the pathogenic state in vitro.
    Type: Grant
    Filed: January 11, 2008
    Date of Patent: August 4, 2015
    Assignee: CORNELL RESEARCH FOUNDATION, INC.
    Inventors: Lonny Levin, Jochen Buck, Leo Brizuela, Michael Pinnisi
  • Adenylyl cyclases as novel targets for antibactrial interventions
    Patent number: 9017681
    Abstract: The present invention relates to a method of preventing or treating a disease caused by bacterial infection by administering an effective amount of a modulator of bacterial adenylyl cyclase. The invention also provides pharmaceutical compositions useful for preventing or treating a disease, with the compositions containing a therapeutically effective amount of a modulator of bacterial adenylyl cyclase. The invention also provides screening methods for identifying selective modulators of bacterial adenylyl cyclase that do not substantially modulate adenylyl cyclase of the subject. The invention also provides methods for culturing bacterial pathogens and methods for inducing the pathogenic state in vitro.
    Type: Grant
    Filed: January 11, 2008
    Date of Patent: April 28, 2015
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Lonny Levin, Jochen Buck, Leo Brizuela, Michael Pinnisi
  • ADENYLYL CYCLASES AS NOVEL TARGETS FOR ANTIBACTRIAL INTERVENTIONS
    Publication number: 20100168203
    Abstract: The present invention relates to a method of preventing or treating a disease caused by bacterial infection by administering an effective amount of a modulator of bacterial adenylyl cyclase. The invention also provides pharmaceutical compositions useful for preventing or treating a disease, with the compositions containing a therapeutically effective amount of a modulator of bacterial adenylyl cyclase. The invention also provides screening methods for identifying selective modulators of bacterial adenylyl cyclase that do not substantially modulate adenylyl cyclase of the subject. The invention also provides methods for culturing bacterial pathogens and methods for inducing the pathogenic state in vitro.
    Type: Application
    Filed: January 11, 2008
    Publication date: July 1, 2010
    Inventors: Lonny Levin, Jochen Buck, Leo Brizuela, Michael Pinnisi
  • ADENYLYL CYCLASES AS NOVEL TARGETS FOR THE TREATMENT OF INFECTION BY EUKARYOTIC PATHOGENS
    Publication number: 20100063099
    Abstract: The present invention relates to a method of preventing or treating a disease caused by infection by a eukaryotic pathogen, wherein the method comprises administering an effective amount of a modulator of a eukaryotic pathogen's adenylyl cyclase. The invention also provides pharmaceutical compositions useful for preventing or treating a disease, with the compositions containing a therapeutically effective amount of a modulator of a eukaryotic pathogen's adenylyl cyclase. The invention also provides screening methods for identifying selective modulators of a eukaryotic pathogen's adenylyl cyclase that do not substantially modulate an adenylyl cyclase of the subject. The invention also provides methods for culturing eukaryotic pathogens and methods for inducing the pathogenic state in vitro.
    Type: Application
    Filed: January 11, 2008
    Publication date: March 11, 2010
    Inventors: Lonny Levin, Jochen Buck, Leo Brizuela, Michael Pinnisi, Leo Brizuela, Michael Pinnisi