Patents by Inventor Leo Frenken

Leo Frenken has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immobilized Single Domain Antigen-Binding Molecules
    Publication number: 20160207986
    Abstract: The immobilisation of single domain antigen binding fragments of antibodies naturally devoid of light chains, or protein domains functionally equivalent thereto, onto a solid surface through covalent cross-linking is described. The binding fragments are devoid of any appended polypeptide tail or linking group. Materials comprising fragments so immobilised and uses thereof are also described.
    Type: Application
    Filed: January 18, 2016
    Publication date: July 21, 2016
    Inventors: Leo Frenken, Steven Grant, Mark Ten Haaft, Cornelis Van Der Logt
  • Production of antibodies
    Publication number: 20060064782
    Abstract: A method for modifying a plant to produce antibodies or active fragments or derivatives thereof in a desired cellular compartment comprising introducing into a plant a DNA sequence encoding a heavy chain immunoglobulin or an active fragment or derivative thereof or a sequence encoding a protein functionally equivalent thereto and plants so modified are disclosed.
    Type: Application
    Filed: November 7, 2005
    Publication date: March 23, 2006
    Inventors: Leo Frenken, Cornelis van der Logt, Yin-Miin Teh, Martine Verhoeyen, Joy Wilkinson, Stephen Jobling
  • Production of antibodies
    Publication number: 20060037107
    Abstract: A method for modifying a plant to produce antibodies or active fragments or derivatives thereof in a desired cellular compartment comprising introducing into a plant a DNA sequence encoding a heavy chain immunoglobulin or an active fragment or derivative thereof or a sequence encoding a protein functionally equivalent thereto and plants so modified are disclosed.
    Type: Application
    Filed: November 7, 2005
    Publication date: February 16, 2006
    Inventors: Leo Frenken, Cornelis van der Logt, Yin-Miin Teh, Martine Verhoeyen, Joy Wilkinson, Stephen Jobling
  • Immunoglobulins and method for their modification
    Publication number: 20050214907
    Abstract: Heavy chain immunoglobulins that comprise an amino acid with a side chain which is not positively charged, in the first tryptic site, especially at position 27, show increased stability in the gastrointestinal tract.
    Type: Application
    Filed: February 4, 2005
    Publication date: September 29, 2005
    Inventors: Edward Dolk, Leo Frenken, Cornelis Verrips