Abstract: Described herein are phenoxy-pyridyl-pyrimidine compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I structure or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: Described herein are phenoxy-pyridazinyl-pyrimidine or phenoxy-pyrimidinyl-pyrimidine compounds and pharmaceutically acceptable salts thereof for use in the treatment of Ire1-mediated diseases and cancer.

Abstract: Described herein are pyrimidinyl-pyridyloxy-naphthyl compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I or I? structure: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I or I? compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: Described herein are pyrimidinyl-pyridyloxy-naphthyl compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I or I? structure: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I or I? compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: Reduction of the complexity of a Viterbi-type sequence detector is disclosed. It was based on elimination of less probably taken branches in the trellis. The method is applied to the design of the E2PR4 channel with 8/9 rate sliding block trellis code. Coding, by itself eliminates two states by coding constraints, and the disclosed method reduces the number of required ACS units from 14 to 11, while reducing their complexity as well. For the implementation of E2PR4 detection, 4 4-way, 3 3-way, 3 2-way and one 1-way ACSs are needed. System simulations show no BER performance drop at common SNRs when compared with a full 16-state E2PR4 implementation in magnetic disk drives.

Abstract: Device and method of EEPR4 post processing in an EPR4 detection system to remove single bit errors by applying 1+D to the samples and comparing this to (1−D)(1+D)3 to the detected EPR4 bits.

Abstract: A circuit for inserting a parity signal into a data stream, including a precoder circuit to precode the data stream to be written on a medium by generating a precoded data stream; a parity circuit to generate a parity signal based on said data stream at a predetermined time; and an insertion circuit to insert said parity signal into said precoded data stream.

Abstract: A method and apparatus encoding and decoding data for storage on a mass storage device is described. The code used is a 5/6 rate code in which a maximum transition run constraint is imposed. This code is designed for use with an EEPR4 read channel and provides a Euclidian squared free distance, d2free, of 10 when used with an EEPR4 partial response filter and a Viterbi decoder.

Abstract: A circuit for inserting a parity signal into a data stream, including a precoder circuit to precode the data stream to be written on a medium by generating a precoded data stream; a parity circuit to generate a parity signal based on said data stream at a predetermined time; and an insertion circuit to insert said parity signal into said precoded data stream.