Patents by Inventor Leo Grady

Leo Grady has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10405925
    Abstract: Systems and methods are disclosed for creating an interactive tool for determining and displaying a functional relationship between a vascular network and an associated perfused tissue. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model, including a tissue region associated with the at least one vessel of the patient; receiving a selected area of the vascular model or a selected area of the tissue model; and generating a display of a region of the tissue model corresponding to the selected area of the vascular model or a display of a portion of the vascular model corresponding to the selected area of the tissue model, respectively.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: September 10, 2019
    Assignee: HEARTFLOW, INC.
    Inventors: Clara Jaquet, Michiel Schaap, Ying Bai, Leo Grady, Charles A. Taylor
  • Patent number: 10398386
    Abstract: Systems and methods are disclosed for estimating patient-specific blood flow characteristics. One method includes acquiring, for each of a plurality of individuals, a geometric model and estimated blood flow characteristics of at least part of the individual's vascular system; executing a machine learning algorithm on the geometric model and estimated blood flow characteristics for each of the plurality of individuals; identifying, using the machine learning algorithm, features predictive of blood flow characteristics corresponding to a plurality of points in the geometric models; acquiring, for a patient, a geometric model of at least part of the patient's vascular system; and using the identified features to produce estimates of the patient's blood flow characteristic for each of a plurality of points in the patient's geometric model.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: September 3, 2019
    Assignee: HeartFlow, Inc.
    Inventors: Leo Grady, Gilwoo Choi, Michael Singer
  • Patent number: 10390885
    Abstract: Systems and methods are disclosed for evaluating cardiovascular treatment options for a patient. One method includes creating a three-dimensional model representing a portion of the patient's heart based on patient-specific data regarding a geometry of the patient's heart or vasculature; and for a plurality of treatment options for the patient's heart or vasculature, modifying at least one of the three-dimensional model and a reduced order model based on the three-dimensional model. The method also includes determining, for each of the plurality of treatment options, a value of a blood flow characteristic, by solving at least one of the modified three-dimensional model and the modified reduced order model; and identifying one of the plurality of treatment options that solves a function of at least one of: the determined blood flow characteristics of the patient's heart or vasculature, and one or more costs of each of the plurality of treatment options.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: August 27, 2019
    Assignee: HeartFlow, Inc.
    Inventors: Ryan Spilker, David Eberle, Leo Grady
  • Publication number: 20190247004
    Abstract: Systems and methods are disclosed for assessing the severity of plaque and/or stenotic lesions using contrast distribution predictions and measurements.
    Type: Application
    Filed: April 26, 2019
    Publication date: August 15, 2019
    Inventors: Charles A. Taylor, Leo Grady, Sethuraman Sankaran, Souma Sengupta, Hyun Jin Kim, Nan Xiao
  • Publication number: 20190247124
    Abstract: Systems and methods are disclosed for simulating or optimizing hemodialysis access. One method includes receiving a patient-specific anatomic model of a patient's vasculature; computing a pre-treatment hemodynamic characteristic of a pre-treatment geometry of a portion of the anatomic model; simulating a post-treatment geometry of a vascular access in the portion of the anatomic model; computing a post-treatment hemodynamic characteristic of the post-treatment geometry of the portion of the anatomic model having the vascular access; and generating a representation of the pre-treatment hemodynamic characteristic or the post-treatment hemodynamic characteristic.
    Type: Application
    Filed: April 29, 2019
    Publication date: August 15, 2019
    Inventors: Sethuraman SANKARAN, Leo Grady, Charles A. Taylor, Christopher K. Zarins
  • Publication number: 20190247123
    Abstract: Systems and methods are disclosed for providing personalized estimates of bioheat transfer through a patient's body or a portion of a patient's body. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model including at least a portion of tissue of the patient's anatomy; receiving an estimate of heat content of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue; determining an estimate of heat distribution of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue based on the vascular model, the tissue model, or the received estimate of heat content; and output the determined estimate of heat distribution to a storage medium or user display.
    Type: Application
    Filed: April 26, 2019
    Publication date: August 15, 2019
    Inventors: Leo GRADY, Charles A. TAYLOR, Christopher K. ZARINS
  • Publication number: 20190231437
    Abstract: A computer implemented method for assessing an arterio-venous malformation (AVM) may include, for example, receiving a patient-specific model of a portion of an anatomy of a patient; using a computer processor to analyze the patient-specific model for identifying one or more blood vessels associated with the AVM, in the patient-specific model; and estimating a risk of an undesirable outcome caused by the AVM, by performing computer simulations of blood flow through the one or more blood vessels associated with the AVM in the patient-specific model.
    Type: Application
    Filed: April 5, 2019
    Publication date: August 1, 2019
    Inventors: Sethuraman SANKARAN, Christopher K. ZARINS, Leo GRADY
  • Publication number: 20190237198
    Abstract: Systems and methods are disclosed for associating medical images with a patient. One method includes: receiving two or more medical images of patient anatomy in an electronic storage medium; generating an anatomical model for each of the received medical images; comparing the generated anatomical models; determining a score assessing the likelihood that the two or more medical images belong to the same patient, using the comparison of the generated anatomical models; and outputting the score to an electronic storage medium or display.
    Type: Application
    Filed: April 10, 2019
    Publication date: August 1, 2019
    Inventors: Leo GRADY, Christopher K. ZARINS, Edward Karl Hahn, III, Ying Bai, Sethuraman SANKARAN, Peter Kersten Petersen, Michiel SCHAAP
  • Patent number: 10354759
    Abstract: Systems and methods are disclosed for modeling changes in patient-specific blood vessel geometry and boundary conditions resulting from changes in blood flow or pressure. One method includes determining, using a processor, a first anatomic model of one or more blood vessels of a patient; determining a biomechanical model of the one or more blood vessels based on at least the first anatomic model; determining one or more parameters associated with a physiological state of the patient; and creating a second anatomic model based on the biomechanical model and the one or more parameters associated with the physiological state.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: July 16, 2019
    Assignee: HeartFlow, Inc.
    Inventors: Charles A. Taylor, Hyun Jin Kim, Sethuraman Sankaran, Michiel Schaap, David Eberle, Gilwoo Choi, Leo Grady
  • Publication number: 20190200881
    Abstract: Systems and methods are disclosed for using patient specific anatomical models and physiological parameters to estimate perfusion of a target tissue to guide diagnosis or treatment of cardiovascular disease. One method includes receiving a patient-specific vessel model and a patent-specific tissue model of a patient anatomy; extracting one or more patient-specific physiological parameters (e.g. blood flow, anatomical characteristics, image characteristics, etc.) from the vessel or tissue models for one or more physiological states of the patient; estimating a characteristic of the perfusion of the patient-specific tissue model (e.g., via a trained machine learning algorithm) using the patient-specific physiological parameters; and outputting the estimated perfusion characteristic to a display.
    Type: Application
    Filed: March 4, 2019
    Publication date: July 4, 2019
    Inventors: Leo Grady, Michiel SCHAAP, Charles A. TAYLOR, Clara JAQUET
  • Publication number: 20190189286
    Abstract: Methods and systems may be used for performing computer-simulated evaluation of treatments. For example, the method may include: for each of a plurality of patients, receiving one or more patient-specific anatomical and/or physiological models; selecting, from the plurality of patients, a set of patients that have one or more common characteristics; for each patient in an experimental group, modifying at least one model of the respective one or more patient-specific models to obtain at least one modified patient-specific model that models an effect of an evaluation treatment on the respective patient, and calculating a value of an evaluation endpoint based on the respective at least one modified patient-specific model; and comparing the calculated values of the evaluation endpoint with one or more control values of the evaluation endpoint for patients that satisfy the one or more selection criterion.
    Type: Application
    Filed: December 19, 2018
    Publication date: June 20, 2019
    Inventor: Leo GRADY
  • Patent number: 10314655
    Abstract: Systems and methods are disclosed for providing personalized estimates of bioheat transfer through a patient's body or a portion of a patient's body. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model including at least a portion of tissue of the patient's anatomy; receiving an estimate of heat content of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue; determining an estimate of heat distribution of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue based on the vascular model, the tissue model, or the received estimate of heat content; and output the determined estimate of heat distribution to a storage medium or user display.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: June 11, 2019
    Assignee: HeartFlow, Inc.
    Inventors: Leo Grady, Charles A. Taylor, Christopher K. Zarins
  • Patent number: 10307131
    Abstract: Systems and methods are disclosed for assessing the severity of plaque and/or stenotic lesions using contrast distribution predictions and measurements.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: June 4, 2019
    Assignee: HeartFlow, Inc.
    Inventors: Charles A. Taylor, Leo Grady, Sethuraman Sankaran, Souma Sengupta, Hyun Jin Kim, Nan Xiao
  • Patent number: 10304569
    Abstract: Systems and methods are disclosed for associating medical images with a patient. One method includes: receiving two or more medical images of patient anatomy in an electronic storage medium; generating an anatomical model for each of the received medical images; comparing the generated anatomical models; determining a score assessing the likelihood that the two or more medical images belong to the same patient, using the comparison of the generated anatomical models; and outputting the score to an electronic storage medium or display.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: May 28, 2019
    Assignee: HeartFlow, Inc.
    Inventors: Leo Grady, Christopher Zarins, Edward Karl Hahn, III, Ying Bai, Sethuraman Sankaran, Peter Kersten Petersen, Michiel Schaap
  • Publication number: 20190156957
    Abstract: Systems and methods are disclosed herein for anatomical modeling using information obtained during a medical procedure, whereby an initial anatomical model is generated or obtained, a correspondence is determined between the initial model and additional data and/or measurements from an invasive or noninvasive procedure, and, if a discrepancy is found between the initial model and the additional data, the anatomical model is updated to incorporate the additional data and reduce the discrepancy.
    Type: Application
    Filed: January 29, 2019
    Publication date: May 23, 2019
    Inventors: Leo GRADY, Charles A. TAYLOR, Campbell ROGERS, Christopher K. ZARINS, Gilwoo CHOI
  • Publication number: 20190142281
    Abstract: Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes receiving one or more vascular models associated with either the patient or with a plurality of individuals; receiving observed perfusion information associated with the patient; and estimating, using one or more computer processors, one or more blood flow characteristics or one or more pathological characteristics of the patient based on the observed perfusion information and the one or more vascular models.
    Type: Application
    Filed: January 7, 2019
    Publication date: May 16, 2019
    Inventors: Leo GRADY, Charles A. TAYLOR
  • Patent number: 10285762
    Abstract: A computer implemented method for assessing an arterio-venous malformation (AVM) may include, for example, receiving a patient-specific model of a portion of an anatomy of a patient; using a computer processor to analyze the patient-specific model for identifying one or more blood vessels associated with the AVM, in the patient-specific model; and estimating a risk of an undesirable outcome caused by the AVM, by performing computer simulations of blood flow through the one or more blood vessels associated with the AVM in the patient-specific model.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: May 14, 2019
    Assignee: HeartFlow, Inc.
    Inventors: Sethuraman Sankaran, Christopher K. Zarins, Leo Grady
  • Publication number: 20190133456
    Abstract: Systems and methods are disclosed for evaluating a patient with vascular disease. One method includes receiving one or more vascular models associated with either the patient or with a plurality of individuals; receiving observed perfusion information associated with the patient; and estimating, using one or more computer processors, one or more blood flow characteristics or one or more pathological characteristics of the patient based on the observed perfusion information and the one or more vascular models.
    Type: Application
    Filed: January 7, 2019
    Publication date: May 9, 2019
    Inventors: Leo GRADY, Charles A. TAYLOR
  • Patent number: 10262101
    Abstract: Systems and methods are disclosed for using patient specific anatomical models and physiological parameters to estimate perfusion of a target tissue to guide diagnosis or treatment of cardiovascular disease. One method includes receiving a patient-specific vessel model and a patent-specific tissue model of a patient anatomy; extracting one or more patient-specific physiological parameters (e.g. blood flow, anatomical characteristics, image characteristics, etc.) from the vessel or tissue models for one or more physiological states of the patient; estimating a characteristic of the perfusion of the patient-specific tissue model (e.g., via a trained machine learning algorithm) using the patient-specific physiological parameters; and outputting the estimated perfusion characteristic to a display.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: April 16, 2019
    Assignee: HEARTFLOW, INC.
    Inventors: Leo Grady, Michiel Schaap, Charles A. Taylor, Clara Jaquet
  • Publication number: 20190095574
    Abstract: Systems and methods are disclosed for identifying and modeling unresolved vessels, and the effects thereof, in image-based patient-specific hemodynamic models. One method includes: receiving, in an electronic storage medium, one or more patient-specific anatomical models representing at least a vessel of a patient; determining, using a processor, the values and characteristics of one or more patient-specific morphometric features in the one or more patient-specific anatomical models; modifying the patient-specific anatomical model using the determined patient-specific morphometric features; and outputting, one or more of, a modified patient-specific anatomical model or a patient-specific morphometric feature to an electronic storage medium or display.
    Type: Application
    Filed: November 21, 2018
    Publication date: March 28, 2019
    Inventors: Charles A. TAYLOR, Hyun Jin KIM, Leo GRADY, Rhea TOMBROPOULOS, Gilwoo CHOI, Nan XIAO, David SPAIN