Patents by Inventor Leo J. J. Backx

Leo J. J. Backx has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Apolipoprotein-.beta. synthesis inhibitors
    Patent number: 5521186
    Abstract: The present invention provides novel compounds of formula ##STR1## the stereochemically isomeric forms thereof, and the pharmaceutically acceptable acid addition salts thereof, wherein A and B taken together form a bivalent radical of formula: --N.dbd.CH-- (a), --CH.dbd.N-- (b), --CH.sub.2 --CH.sub.2 -- (c), --CH.dbd.CH-- (d) --C(.dbd.O)--CH.sub.2 -- (e), --CH.sub.2 --C(.dbd.O)-- (f); R.sup.1 is hydrogen, C.sub.1-6 alkyl, or halo; R.sup.2 is hydrogen or halo; R.sup.3 is hydrogen; C.sub.1-8 alkyl; C.sub.3-6 cycloalkyl or C.sub.1-8 alkyl substituted with hydroxy, oxo, C.sub.3-6 cycloalkyl or aryl. Het is five- or six-membered optionally substituted heterocyclic ring. The use as a medicine, especially as a lipid lowering agent is disclosed as well as pharmaceutical compositions and processes for preparing compounds and compositions.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: May 28, 1996
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Robert J. M. Hendrickx, Luc A. L. Van Der Eycken, Didier R. G. G. De Chaffoy De Courcelles
  • Antifungal 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-y l]methoxy]phenyl]-1-piperazinyl]phenyl]triazolones and imidazolones
    Patent number: 5075309
    Abstract: 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]m ethoxy]phenyl]-1-piperazinyl]phenyl]triazolones and imidazolones, their pharmaceutically acceptable acid addition salts and stereoisomeric forms having improved antifungal properties, compositions containing the same, and methods of inhibiting and/or preventing the growth or the development of fungi, or of destroying fungi, in warm-blooded animals suffering from diseases caused by these fungi.
    Type: Grant
    Filed: May 1, 1990
    Date of Patent: December 24, 1991
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx
  • 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
    Patent number: 4931444
    Abstract: 4-(4-phenyl-1-piperazinyl)phenols for use as 5-lipoxygenase inhibitors and a method of treating warm-blooded animals suffering from leukotriene mediated diseases and disorders using the same. Pharmaceutical compositions containing the same as active ingredient. Novel compounds used in said method and processes for preparing said novel compounds.
    Type: Grant
    Filed: January 12, 1989
    Date of Patent: June 5, 1990
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jean P. F. Van Wauwe, Jan Heeres, Leo J. J. Backx
  • 4-[4-[4-[4-[[2-(2,4-difluoro phenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]ph enyl]triazolones
    Patent number: 4916134
    Abstract: 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]m ethoxy]phenyl]-1-piperazinyl]phenyl]triazolones, their pharmaceutically acceptable acid addition salts and stereoisomeric forms having improved antimicrobial properties, compositions containing the same, and methods of inhibiting and/or eliminating the development of fungi and bacteria in warm-blooded animals suffering from diseases caused by these fungi and/or bacteria.
    Type: Grant
    Filed: April 7, 1989
    Date of Patent: April 10, 1990
    Assignee: Janssen Pharmacuetica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Louis J. E. Van der Veken
  • [ [4-[4-Phenyl-1-piperazinyl)phenoxymethyl]-1-3-dioxolan-2-yl]-methyl]-1H-i midazoles and 1H-1,2,4-triazoles
    Patent number: 4861879
    Abstract: Substituted [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H -imidazoles and 1H-1,2,4-triazoles having antimicrobial properties and being particularly useful in the treatment of vaginal candidosis.
    Type: Grant
    Filed: February 9, 1988
    Date of Patent: August 29, 1989
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Raymond A. Stokbroekx, Leo J. J. Backx
  • [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]- 1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties
    Patent number: 4791111
    Abstract: Novel [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H -imidazoles and 1H-1,2,4-triazoles, having anti-microbial activity, compositions containing the same, and methods of inhibiting and/or eliminating the development of fungi and bacteria in warm-blooded animals suffering from diseases caused by these fungi and/or bacteria.
    Type: Grant
    Filed: October 16, 1986
    Date of Patent: December 13, 1988
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Jozef B. A. Thijssen, Alfonsus G. Knaeps
  • [[4 -[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]-methyl]-1H- imidazoles and 1H-1,2,4-triazoles having antimicrobial properties
    Patent number: 4735942
    Abstract: Substituted [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3 dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having antimicrobial properties and being particularly useful in the treatment of vaginal candidosis.
    Type: Grant
    Filed: June 2, 1986
    Date of Patent: April 5, 1988
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Raymond A. Stokbroekx, Leo J. J. Backx
  • [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-diox olan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
    Patent number: 4619931
    Abstract: Substituted [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H -imidazoles and 1H-1,2,4-triazoles having antimicrobial properties and being particularly useful in the treatment of vaginal candidosis.
    Type: Grant
    Filed: January 9, 1984
    Date of Patent: October 28, 1986
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Raymond A. Stokbroekx, Leo J. J. Backx
  • Fungicidal 1-(2-aryl-2-R-ethyl)-1H-1,2,4-triazoles
    Patent number: 4598085
    Abstract: Novel compounds of the class of 1-(2-aryl-2-R-ethyl)-1H-1,2,4-triazoles having fungicidal and plant-growth regulating properties.
    Type: Grant
    Filed: January 21, 1982
    Date of Patent: July 1, 1986
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph A. Mostmans
  • Antimicrobial imidazole derivatives
    Patent number: 4524110
    Abstract: The invention is concerned with novel dithioketal derivatives of 1-(2-aryl-2-oxoethyl)-1H-imidazoles and sulfones and sulfoxides derived therefrom, said compounds being useful as antimicrobial agents.
    Type: Grant
    Filed: September 28, 1984
    Date of Patent: June 18, 1985
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
  • Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)-methyl-1H-imida zoles and 1H-1,2,4-triazoles
    Patent number: 4490530
    Abstract: Novel heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazol es and 1H-1,2,4-triazoles, useful as intermediates and as antifungal and antibacterial agents.
    Type: Grant
    Filed: September 28, 1982
    Date of Patent: December 25, 1984
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx
  • Antimicrobial imidazole derivatives
    Patent number: 4483865
    Abstract: The invention is concerned with novel dithioketal derivatives of 1-(2-aryl-2-oxoethyl)-1H-imidazoles and sulfones and sulfoxides derived therefrom, said compounds being useful as antimicrobial agents.
    Type: Grant
    Filed: January 25, 1982
    Date of Patent: November 20, 1984
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
  • Heterocyclic derivatives of (4-phenyl-piperazine-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)-methyl-1H-imi dazoles and 1H-1,2,4-triazoles
    Patent number: 4368200
    Abstract: Novel heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazol es and 1H-1,2,4-triazoles, useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: January 14, 1981
    Date of Patent: January 11, 1983
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx
  • 1-(1,3-Dioxolan-2-ylmethyl)-1H-1,2,4-triazoles and compositions
    Patent number: 4358449
    Abstract: 1-(1,3,-Dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: February 15, 1980
    Date of Patent: November 9, 1982
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
  • 1-(1,3-Dioxolan-2-ylmethyl)-1H-imidazoles
    Patent number: 4335125
    Abstract: Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: January 8, 1979
    Date of Patent: June 15, 1982
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
  • Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles
    Patent number: 4268680
    Abstract: Novel intermediates for making heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles, useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: June 20, 1979
    Date of Patent: May 19, 1981
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
  • Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidaz oles and 1H-1,2,4-triazoles
    Patent number: 4267179
    Abstract: Novel heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazol es and 1H-1,2,4-triazoles, useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: March 14, 1979
    Date of Patent: May 12, 1981
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Leo J. J. Backx
  • Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-1,2,4-triazoles
    Patent number: 4244964
    Abstract: Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-1,2,4-triazoles useful as anti-fungal and anti-bacterial agents.
    Type: Grant
    Filed: June 20, 1979
    Date of Patent: January 13, 1981
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
  • Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
    Patent number: 4232034
    Abstract: Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles useful as anti-fungal and anti-bacterial agents.
    Type: Grant
    Filed: June 20, 1979
    Date of Patent: November 4, 1980
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
  • Hydrazine carboxamide derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles
    Patent number: 4229581
    Abstract: Novel hydrazine carboxamide intermediates for making heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles, useful as antifungal and antibacterial agents.
    Type: Grant
    Filed: June 20, 1979
    Date of Patent: October 21, 1980
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans