Abstract: The present invention relates to modified fusion proteins and nucleic acid constructs suitable for use for protein degradation in cells. The fusion proteins comprise a RING domain; and an adaptor domain that is capable of localising the RING domain with a substrate. The fusion proteins are unable to undergo N-terminal autoubiquitination and have increased cellular half-life. The present invention also relates to compositions comprising these fusion proteins and nucleic acids, and the use of the fusion proteins and nucleic acid constructs in therapy.

Abstract: The present invention relates to fusion proteins comprising at least two RING domains and a protein targeting domain, and nucleic acid constructs encoding the same suitable for use for protein degradation in cells. The present invention also relates to compositions comprising these fusion proteins and nucleic acids, and the use of the fusion proteins and nucleic acid constructs in therapy.

Abstract: An example approach is provided for managing service requests. An input, from a device of a user, for a service request associated with a specified service and/or a product is processed.

Abstract: An example approach is provided for generating and managing service requests. One or more service requests are generated. Further, the one or more requests are assigned to one or more service providers and are aggregated. Furthermore, one or more updates are presented on at least a portion of the aggregation.