Patents by Inventor Leo Kim

Leo Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11963905
    Abstract: Methods of delivering agents to structures within the eye are provided.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: April 23, 2024
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Jason Comander, Dean Eliott, Leo Kim, Luk H. Vandenberghe
  • Publication number: 20210196508
    Abstract: Methods of delivering agents to structures within the eye are provided.
    Type: Application
    Filed: January 4, 2021
    Publication date: July 1, 2021
    Inventors: Jason Comander, Dean Eliott, Leo Kim, Luk H. Vandenberghe
  • Patent number: 10906969
    Abstract: Methods of treating acute thyroid eye disease (TED) by administering a inhibitor, e.g., a VEGF-A inhibitor, e.g., an anti-VEGF antibody, optionally in combination with hyaluronidase, by periorbital or intraorbital injection. Also compositions comprising a VEGF inhibitor and hyaluronidase.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: February 2, 2021
    Assignees: Massachusetts Eye and Ear Infirmary, The Schepens Eye Research Institute, Inc.
    Inventors: N. Grace Lee, Leo Kim, Patricia A. D'Amore, James A. Stefater
  • Patent number: 10881548
    Abstract: Methods of delivering agents to structures within the eye are provided.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: January 5, 2021
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Jason Comander, Dean Eliott, Leo Kim, Luk H. Vandenberghe
  • Publication number: 20190276529
    Abstract: Methods of treating acute thyroid eye disease (TED) by administering a inhibitor, e.g., a VEGF-A inhibitor, e.g., an anti-VEGF antibody, optionally in combination with hyaluronidase, by periorbital or intraorbital injection. Also compositions comprising a VEGF inhibitor and hyaluronidase.
    Type: Application
    Filed: June 8, 2017
    Publication date: September 12, 2019
    Applicants: Massachusetts Eye and Ear Infirmary
    Inventors: N. Grace LEE, Leo KIM, Patricia A. D`AMORE, James A. STEFATER
  • Patent number: 9986905
    Abstract: In some example implementations, there is provided a method for predicting retinal degeneration in multiple eye diseases. The method may include receiving three-dimensional data representative of a plurality of layers of a retina of a subject under test; determining, from the received data, oxygen concentration at one or more of the plurality of layers; detecting, based on the determined oxygen concentration, a region of at least one a high oxygen concentration in the retina or a low oxygen concentration in the retina; and comparing the detected region to reference data to determine whether the retina including the detected region suffers from or will suffer from at least one of a retinal disease or a degeneration of the retina. Related apparatus are also disclosed.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: June 5, 2018
    Assignee: The Schepens Eye Research Institute, Inc.
    Inventors: Kevin McHugh, Magali Saint-Geniez, Leo Kim
  • Publication number: 20180116869
    Abstract: Methods of delivering agents to structures within the eye are provided.
    Type: Application
    Filed: May 6, 2016
    Publication date: May 3, 2018
    Inventors: Jason Comander, Dean Eliott, Leo Kim, Luk H. Vandenberghe
  • Publication number: 20160100752
    Abstract: In some example implementations, there is provided a method for predicting retinal degeneration in multiple eye diseases. The method may include receiving three-dimensional data representative of a plurality of layers of a retina of a subject under test; determining, from the received data, oxygen concentration at one or more of the plurality of layers; detecting, based on the determined oxygen concentration, a region of at least one a high oxygen concentration in the retina or a low oxygen concentration in the retina; and comparing the detected region to reference data to determine whether the retina including the detected region suffers from or will suffer from at least one of a retinal disease or a degeneration of the retina. Related apparatus are also disclosed.
    Type: Application
    Filed: April 23, 2014
    Publication date: April 14, 2016
    Inventors: Kevin McHugh, Magali Saint-Geniez, Leo Kim
  • Patent number: 7091177
    Abstract: The subject invention concerns the discovery of Bacillus thuringiensis isolates with advantageous activity against weevils. In preferred embodiments of the invention, B.t. isolates, or toxins therefrom, are used to control alfalfa weevils, boll weevils, and/or rice water weevils. The toxins can be administered to the pests through a variety of methods including the transformation of bacteria or plants to produce the weevil-active toxins.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: August 15, 2006
    Assignee: Mycogen Corporation
    Inventors: Gregory A. Bradfisch, H. Ernest Schnepf, Leo Kim
  • Publication number: 20040033953
    Abstract: The subject invention concerns the discovery of Bacillus thuringiensis isolates with advantageous activity against weevils. In preferred embodiments of the invention, B.t. isolates, or toxins therefrom, are used to control alfalfa weevils, boll weevils, and/or rice water weevils. The toxins can be administered to the pests through a variety of methods including the transformation of bateria or plants to produce the weevil-active toxins.
    Type: Application
    Filed: July 30, 2003
    Publication date: February 19, 2004
    Applicant: Mycogen Corporation
    Inventors: Gregory A. Bradfisch, H. Ernest Schnepf, Leo Kim
  • Patent number: 6605462
    Abstract: The subject invention concerns the discovery of Bacillus thuringiensis isolates with advantageous activity against weevils. In preferred embodiments of the invention, B.t. isolates, or toxins therefrom, are used to control alfalfa weevils, boll weevils, and/or rice water weevils. The toxins can be administered to the pests through a variety of methods including the transformation of bacteria or plants to produce the weevil-active toxins.
    Type: Grant
    Filed: December 14, 2000
    Date of Patent: August 12, 2003
    Assignee: Mycogen Corp.
    Inventors: Gregory A. Bradfisch, H. Ernest Schnepf, Leo Kim
  • Publication number: 20010001710
    Abstract: The subject invention concerns the discovery of Bacillus thuringiensis isolates with advantageous activity against weevils. In preferred embodiments of the invention, B.t. isolates, or toxins therefrom, are used to control alfalfa weevils, boll weevils, and/or rice water weevils. The toxins can be administered to the pests through a variety of methods including the transformation of bacteria or plants to produce the weevil-active toxins.
    Type: Application
    Filed: December 14, 2000
    Publication date: May 24, 2001
    Inventors: Gregory A. Bradfisch, H. Ernest Schnepf, Leo Kim
  • Patent number: 6180775
    Abstract: The subject invention concerns the discovery of Bacillus thuringiensis isolates with advantageous activity against weevils. In preferred embodiments of the invention, B.t. isolates, or toxins therefrom, are used to control alfalfa weevils, boll weevils, and/or rice water weevils. The toxins can be administered to the pests through a variety of methods including the transformation of bacteria or plants to produce the weevil-active toxins.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: January 30, 2001
    Assignee: Mycogen Corporation
    Inventors: Gregory A. Bradfisch, H. Ernest Schnepf, Leo Kim
  • Patent number: 5707619
    Abstract: The subject invention concerns the discovery of Bacillus thuringiensis isolates with advantageous activity against weevils. In preferred embodiments of the invention, B.t. isolates, or toxins therefrom, are used to control alfalfa weevils, boll weevils, and/or rice water weevils. The toxins can be administered to the pests through a variety of methods including the transformation of bacteria or plants to produce the weevil-active toxins.
    Type: Grant
    Filed: March 6, 1995
    Date of Patent: January 13, 1998
    Assignee: Mycogen Corporation
    Inventors: Gregory A. Bradfisch, H. Ernest Schnepf, Leo Kim
  • Patent number: 5698592
    Abstract: Methods and compositions for the control of nematodes are disclosed. Specifically, fatty acid ester compounds have been found to advantageously control nematodes at concentrations which are non-phytotoxic. The fatty acid ester compounds can be used in conjunction with other nematicidal agents such as free fatty acids, fatty acid salts, avermectins, ivermectin, and milbemycin.
    Type: Grant
    Filed: October 17, 1996
    Date of Patent: December 16, 1997
    Assignee: Mycogen Corporation
    Inventors: Leo Kim, Jerald S. Feitelson, John Harvey, Paul S. Zorner
  • Patent number: 5674897
    Abstract: Methods and compositions for the control of nematodes are disclosed. Specifically, fatty acid ester compounds have been found to advantageously control nematodes at concentrations which are non-phytotoxic. The fatty acid ester compounds can be used in conjunction with other nematicidal agents such as free fatty acids, fatty acid salts, avermectins, ivermectin, and milbemycin.
    Type: Grant
    Filed: October 20, 1995
    Date of Patent: October 7, 1997
    Assignee: Mycogen Corporation
    Inventors: Leo Kim, Jerald S. Feitelson, John Harvey, Paul S. Zorner
  • Patent number: 4452433
    Abstract: A carrying tower for a metallurgical vessel includes at least one carrying arm cantilevering from a non-rotatable carrying column and pivotable about the carrying column, which carrying arm carries at least one metallurgical vessel. A pivot bearing is provided between the carrying arm and the carrying column. In order to enable a simple check, maintenance and a quick removal of the pivot bearing with the carrying arm remaining on the carrying tower, a single pivot bearing accommodating axial and radial forces as well as tilting moments, with a lower-side shoulder of a first bearing race, rests on a supporting surface arranged on the upper end of the carrying column. The carrying arm is mounted so as to be suspended on a second bearing race of the pivot bearing.
    Type: Grant
    Filed: October 4, 1982
    Date of Patent: June 5, 1984
    Assignee: Voest-Alpine Aktiengesellschaft
    Inventors: Gerhard Muhlbauer, Franz Kagerhuber, Werner Glatz, Erich Felbermayer, Leo Kim
  • Patent number: 4418203
    Abstract: A process for the epoxidation of olefins wherein an olefin is contacted with hydrogen peroxide in a fluorinated alcoholic solvent in which are dissolved a catalyst selected from a group consisting of molybdenum, tungsten and rhenium and an organo tin co-catalyst.
    Type: Grant
    Filed: December 21, 1981
    Date of Patent: November 29, 1983
    Assignee: Shell Oil Company
    Inventor: Leo Kim
  • Patent number: 4384044
    Abstract: This invention relates to a process for the production of a polysaccharide wherein a microorganism species which produces polysaccharide (preferably in the stationary phase of the growth cycle) is supported on a porous, particulate inert support, the pore size being greater than about 0.5 .mu.m, to form an immobilized cell system, aqueous nutrient medium is passed through the immobilized system, and polysaccharide-containing medium is withdrawn from the system. The invention provides also for the use of the polysaccharide in the displacement of fluid from subsurface formations, and an immobilized cell system for use in the foregoing process.
    Type: Grant
    Filed: August 18, 1981
    Date of Patent: May 17, 1983
    Assignee: Shell Oil Company
    Inventors: Leo Kim, Stuart G. Ash
  • Patent number: 4371716
    Abstract: An improved process for preparing .beta.-(sec-alkoxy) ethanol which comprises reacting an olefin with ethylene glycol in the presence of a sulfuric acid or benzenesulfonic acid catalyst and sufficient sulfolane or alkyl-substituted sulfolane solvent to provide a one phase reaction medium, extracting the reaction products with an alkane and recovering the .beta.-(sec-alkoxy) ethanol product from the alkane extract.
    Type: Grant
    Filed: July 17, 1981
    Date of Patent: February 1, 1983
    Assignee: Shell Oil Company
    Inventors: Timm E. Paxson, Leo Kim, Andre B. Van Aken