Patents by Inventor Leo Linbeck, III
Leo Linbeck, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11433396Abstract: In a polymer assay cartridge having wells containing reagents, beads and sample, where the wells are covered (e.g., with Parafilm® or films) and shipped to the point of care, the reagents and well contents can leak out. The reagent solutions are made semi-solid by adding hydrogel reagents and cooling to form a gel. Preferably, the hydrogel is heated before an assay is conducted with the cartridge, and pigmented beads in the wells indicate melting or excessive heating, or congealing of the hydrogel, based on pigment color change.Type: GrantFiled: August 5, 2020Date of Patent: September 6, 2022Assignee: Fannin Partners LLCInventors: Leo Linbeck, III, Dev Chatterjee, Michael John Heffernan
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Publication number: 20220192810Abstract: The present invention relates to the application of medical devices that manage urinary incontinence. The inter-bladder/urethra implanted device allows for passive urine leakage above a threshold bladder pressure and subject-controlled opening and closing of a valve to allow urine passage, below the threshold bladder pressure. The valve is preferably a deformable sac which seals against the interior of the urethra when closed. The valve can be opened by withdrawing slightly from the urethra surface. Passive urine leakage to prevent over-pressure can be facilitated by including external channels on the valve sac. In another embodiment, the valve sac has a central passage which expands and contracts for opening and closing, respectively.Type: ApplicationFiled: December 21, 2021Publication date: June 23, 2022Inventors: Leo LINBECK, III, Michael John Heffernan, Deepti Gopinath, Christine Luk, Carine Rizk, Amanda Gibbens
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Patent number: 11327087Abstract: The invention herein relates to conducting assays with an apparatus including a substantially transparent assay cartridge loaded with magnetic beads, and a magnets positioned in a platform above and below the assay cartridge. The assay cartridge includes magnetic beads, sample and control solutions in some wells, and assay reagents in others. A microcomputer controls a linear actuator which moves the magnet platform causing the magnetic beads to travel from one well to another and to oscillate within a well. At assay completion, the cartridge will generate a signal representing a test result, which is then sent to a server through a wireless transmission system.Type: GrantFiled: April 13, 2020Date of Patent: May 10, 2022Assignee: BREVITEST TECHNOLOGIES, LLCInventors: Leo Linbeck, III, Javier Trinidad Garza, Jr., Robert Patrick Garr, Dev Chatterjee
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Patent number: 11110459Abstract: In a polymer assay cartridge having wells containing reagents, beads and sample, where the wells are covered (e.g., with Parafilm® or films) and shipped to the point of care, the reagents and well contents can leak out. The reagent solutions are made semi-solid by adding hydrogel reagents and cooling to form a gel. Preferably, the hydrogel is heated before an assay is conducted with the cartridge, and pigmented beads in the wells indicate melting or excessive heating, or congealing of the hydrogel, based on pigment color change.Type: GrantFiled: November 13, 2018Date of Patent: September 7, 2021Assignee: Fannin Partners LLCInventors: Dev Chatterjee, Leo Linbeck, III, Michael John Heffernan
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Publication number: 20200393453Abstract: In a polymer assay cartridge having wells containing reagents, beads and sample, where the wells are covered (e.g., with Parafilm® or films) and shipped to the point of care, the reagents and well contents can leak out. The reagent solutions are made semi-solid by adding hydrogel reagents and cooling to form a gel.Type: ApplicationFiled: August 5, 2020Publication date: December 17, 2020Inventors: Dev Chatterjee, Leo Linbeck, III, Michael John Heffernan
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Patent number: 10828636Abstract: The invention relates to conducting assays with an apparatus including a substantially transparent assay cartridge loaded with magnetic beads, and a magnet carrier base positioned below a scanning platform holding the assay cartridge. A microcomputer controls a stepping motor which controls movement of the magnet carrier base, and causes the magnetic beads to travel from one well to another, where the wells contain different assay reagents. An electromagnetic coil-spring assembly induces mixing of well contents with the magnetic beads on actuation. The assay cartridge is authenticated by sending its encoded identifier to a server or website, and assay instructions are provided remotely to the microcomputer. Following assay completion, the cartridge can have color change or other assay indication detected, and the results sent to the server or website or another recipient. Concurrently assaying a control allows modification of assay results based on measured field conditions.Type: GrantFiled: October 25, 2017Date of Patent: November 10, 2020Assignee: FANNIN PARTNERS LLCInventors: Leo Linbeck, III, Michael John Heffernan, Dev Chatterjee, Atul Varadhachary
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Patent number: 10737270Abstract: In a polymer assay cartridge having wells containing reagents, beads and sample, where the wells are covered (e.g., with Parafilm® or films) and shipped to the point of care, the reagents and well contents can leak out. The reagent solutions are made semi-solid by adding hydrogel reagents and cooling to form a gel. Preferably, the hydrogel is heated before an assay is conducted with the cartridge, and pigmented beads in the wells indicate melting or excessive heating, or congealing of the hydrogel, based on pigment color change.Type: GrantFiled: November 12, 2018Date of Patent: August 11, 2020Assignee: Fannin Partners, LLCInventors: Leo Linbeck, III, Michael John Heffernan, Dev Chatterjee
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Patent number: 10252268Abstract: The invention herein relates to conducting assays with an apparatus including a substantially transparent assay cartridge loaded with magnetic beads, and a magnet carrier base positioned below a scanning platform holding the assay cartridge. The assay cartridge includes magnetic beads, sample and control solutions in some wells, and assay reagents in others. A microcomputer controls a DC motor which controls movement of the magnet carrier base, and causes the magnetic beads to travel from one well to another. An electromagnetic coil-spring assembly induces mixing of well contents with the magnetic beads on actuation. The assay cartridge is authenticated by sending its encoding to a server or website, and assay instructions are provided remotely to the microcomputer. Following assay completion, the cartridge can have color change or other assay indication detected, and the results sent to the server or website or another recipient.Type: GrantFiled: December 26, 2016Date of Patent: April 9, 2019Assignee: Fannin Partners LLCInventors: Leo Linbeck, III, Michael John Heffernan, Dev Chatterjee
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Publication number: 20190091691Abstract: In a polymer assay cartridge having wells containing reagents, beads and sample, where the wells are covered (e.g., with Parafilm® or films) and shipped to the point of care, the reagents and well contents can leak out. The reagent solutions are made semi-solid by adding hydrogel reagents and cooling to form a gel.Type: ApplicationFiled: November 12, 2018Publication date: March 28, 2019Inventors: Dev Chatterjee, Leo Linbeck, III, Michael John Heffernan
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Patent number: 10195609Abstract: In a polymer assay cartridge having wells containing reagents, beads and sample, where the wells are covered (e.g., with Parafilm® or films) and shipped to the point of care, the reagents and well contents can leak out. The reagent solutions are made semi-solid by adding hydrogel reagents and cooling to form a gel. Preferably, the hydrogel is heated before an assay is conducted with the cartridge, and pigmented beads in the wells indicate melting or excessive heating, or congealing of the hydrogel, based on pigment color change.Type: GrantFiled: October 25, 2017Date of Patent: February 5, 2019Assignee: Fannin Partners, LLCInventors: Dev Chatterjee, Leo Linbeck, III, Michael John Heffernan, Brad Ernest Munoz, Atul Varadhachary
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Patent number: 10126297Abstract: The invention herein relates to conducting assays with an apparatus including a substantially transparent assay cartridge loaded with magnetic beads, and a magnet carrier base positioned below a scanning platform holding the assay cartridge. The assay cartridge includes magnetic beads, sample and control solutions in some wells, and assay reagents in others. A microcomputer controls a stepping motor which controls movement of the magnet carrier base, and causes the magnetic beads to travel from one well to another. An electromagnetic coil-spring assembly induces mixing of well contents with the magnetic beads on actuation. The assay cartridge is authenticated by sending its encoded identifier to a server or website, and assay instructions are provided remotely to the microcomputer. Following assay completion, the cartridge can have color change or other assay indication detected, and the results sent to the server or website or another recipient.Type: GrantFiled: October 25, 2017Date of Patent: November 13, 2018Assignee: Fannin Partners, LLCInventors: Dev Chatterjee, Leo Linbeck, III, Michael John Heffernan, Atul Varadhachary
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Patent number: 9528985Abstract: Disclosed herein are systems and methods for using the controlled movement of magnetic particles using controlled magnetic fields in a fluidic device containing separated fluidic regions to detect analytes in solution by immunoassay, such as an enzyme-linked immunosorbant assay (ELISA) for various medical and scientific applications. In order to achieve sequential exposure to the different chemical environments required in an immunoassay, magnetic particles are driven through fluid-containing chambers separated by air-gaps that may take the form of air bubbles or small open-air separations, for example. Externally controlled magnets coupled to actuators draw the flow of magnetic particles through air-liquid interfaces produced by microfluidic surface tension at the air-gap, washing the particles.Type: GrantFiled: January 11, 2016Date of Patent: December 27, 2016Assignee: FANNIN INNOVATION STUDIO, INC.Inventors: Dev Chatterjee, Atul Varadhachary, Leo Linbeck, III
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Publication number: 20090246196Abstract: A method of treating an individual comprising: evaluating the disease state of said individual through quantitative and/or qualitative assays; administering in amounts sufficient to treat said disease at least three agents wherein at least one agent is an inhibitor of the human epidermal receptor pathway, at least one agent is signal transduction inhibitor and at least one agent is an angiogenesis inhibitor and; reevaluating the disease state of said individual presenting through quantitative and/or qualitative assays. A composition comprising a first agent that is an inhibitor of the human epidermal receptor pathway, a second agent that is an angiogenesis inhibitor and a third agent that is an inhibitor of Akt wherein said first agent, second agent, third agent and combinations thereof are present in amounts that when administered to an individual in a diseased state are sufficient to treat said disease.Type: ApplicationFiled: March 15, 2007Publication date: October 1, 2009Inventors: Leo Linbeck, III, Martin Lindenberg, John J. Nemunaitis, Neil Senzer, David Shanahan