Patents by Inventor Leo M. Albert

Leo M. Albert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted benzoxazoles as estrogenic agents
    Patent number: 7531564
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2006
    Date of Patent: May 12, 2009
    Assignee: Wyeth
    Inventors: Michael S. Malamas, Robert E. McDevitt, Iwan Gunawan, Eric S. Manas, Michael D. Collini, Heather A. Harris, James C. Keith, Jr., Leo M. Albert, C. Richard Lyttle
  • 6-Hydroxyequilenins as estrogenic agents
    Patent number: 7235539
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1 is hydrogen, alkyl of 1–6 carbon atoms, benzyl, alkylcarbonyl of 2–7 carbon atoms, or benzoyl; X is R2 is hydrogen, alkyl of 1–6 carbon atoms, benzyl, alkylcarbonyl of 2–7 carbon atoms, or benzoyl; R3 is hydrogen, alkyl of 1–6 carbon atoms, hydroxy, or alkoxy of 1–6 carbon atoms; a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable salt of a sulfate ester of the hydroxyl group at the 3- or 17-position when R1 or R2 is hydrogen, or a glucuronide of the hydroxyl group at the 3- or 17-position when R1 or R2 is hydrogen.
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: June 26, 2007
    Assignee: Wyeth
    Inventors: Heather A. Harris, James C. Keith, Jr., Leo M. Albert, Galina Vid, Sreenivasulu Megati, Christopher P. Miller
  • Substituted benzoxazoles as estrogenic agents
    Patent number: 7148247
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: December 12, 2006
    Assignee: Wyeth
    Inventors: Michael S Malamas, Robert E McDevitt, Iwan Gunawan, Eric S Manas, Michael D Collini, Heather A Harris, James C Keith, Jr., Leo M Albert, Cecil Richard Lyttle
  • Substituted phenyl naphthalenes as estrogenic agents
    Patent number: 7067524
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10, are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 18, 2004
    Date of Patent: June 27, 2006
    Assignee: Wyeth
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Cuijian Yang, Heather A. Harris, James C. Keith, Jr., Leo M. Albert, Eric S. Manas
  • Substituted 2-phenyl benzofurans as estrogenic agents
    Patent number: 7022733
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R, R?, A, A?, X, Y, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: April 4, 2006
    Assignee: Wyeth
    Inventors: Christopher P. Miller, Michael D. Collini, David H. Kaufman, Robert L. Morris, Robert R. Singhaus, Jr., John W. Ullrich, Heather A. Harris, James C. Keith, Jr., Leo M. Albert, Rayomand J. Unwalla
  • Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents
    Patent number: 6960607
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: November 1, 2005
    Assignee: Wyeth
    Inventors: Michael S. Malamas, Iwan Gunawan, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
  • Substituted phenyl naphthalenes as estrogenic agents
    Patent number: 6914074
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10, are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: July 5, 2005
    Assignee: Wyeth
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Cuijian Yang, Heather A. Harris, James C. Keith, Jr., Leo M. Albert, Eric S. Manas
  • Substituted indenones as estrogenic agents
    Patent number: 6903238
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure R1, R2, and R3 are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: June 7, 2005
    Assignee: Wyeth
    Inventors: Robert E. McDevitt, Folake O. Adebi, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
  • Phenyl benzisoxazoles as estrogenic agents
    Patent number: 6884814
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, and R3 are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: April 26, 2005
    Assignee: Wyeth
    Inventors: Michael S. Malamas, Tam Q. Dinh, Iwan Gunawan, Michael D. Collini, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
  • Phenyl substituted thiophenes as estrogenic agents
    Patent number: 6835745
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, R3, X, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: December 28, 2004
    Assignee: Wyeth
    Inventors: Richard D. Coghlan, William F. Fobare, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
  • Substituted phenyl naphthalenes as estrogenic agents
    Publication number: 20040225123
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: March 18, 2004
    Publication date: November 11, 2004
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Cuijian Yang, Heather A. Harris, James C. Keith, Leo M. Albert, Eric S. Manas
  • Substituted 2-phenyl benzofurans as estrogenic agents
    Patent number: 6774248
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R, R′, A, A′, X, Y, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 16, 2002
    Date of Patent: August 10, 2004
    Assignee: Wyeth
    Inventors: Christopher P. Miller, Michael D. Collini, David H. Kaufman, Robert L. Morris, Robert R. Singhaus, Jr., John W. Ullrich, Heather A. Harris, James C. Keith, Jr., Leo M. Albert, Rayomand J. Unwalla
  • Substituted 6H-DiBenzo[c,h]chromenes as estrogenic agents
    Patent number: 6723747
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4 R5, R6, and R7 are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: April 20, 2004
    Assignee: Wyeth
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Stephen T. Cohn, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
  • Phenyl benzisoxazoles as estrogenic agents
    Publication number: 20030207927
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: December 11, 2002
    Publication date: November 6, 2003
    Applicant: Wyeth
    Inventors: Michael S. Malamas, Tam Q. Dinh, Iwan Gunawan, Michael D. Collini, Heather A. Harris, James C. Keith, Leo M. Albert
  • Phenyl substituted thiophenes as estrogenic agents
    Publication number: 20030199570
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: January 10, 2003
    Publication date: October 23, 2003
    Inventors: Richard D. Coghlan, William F. Fobare, Heather A. Harris, James C. Keith, Leo M. Albert
  • Substituted benzoxazoles as estrogenic agents
    Publication number: 20030199562
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: December 4, 2002
    Publication date: October 23, 2003
    Applicant: Wyeth
    Inventors: Michael S. Malamas, Robert E. McDevitt, Iwan Gunawan, Eric S. Manas, Michael D. Collini, Heather A. Harris, James C. Keith, Leo M. Albert, C. Richard Lyttle
  • Substituted phenyl naphthalenes as estrogenic agents
    Publication number: 20030181519
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: December 11, 2002
    Publication date: September 25, 2003
    Applicant: Wyeth
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Cuijian Yang, Heather A. Harris, James C. Keith, Leo M. Albert
  • Substituted 6H-DiBenzo[c,h]chromenes as estrogenic agents
    Publication number: 20030176491
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: December 11, 2002
    Publication date: September 18, 2003
    Applicant: Wyeth
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Stephen T. Cohn, Heather A. Harris, James C. Keith, Leo M. Albert
  • Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents
    Publication number: 20030171412
    Abstract: This invention provides estrogen receptor modulators of formula 1, having the structure 1
    Type: Application
    Filed: December 11, 2002
    Publication date: September 11, 2003
    Applicant: Wyeth
    Inventors: Michael S. Malamas, Iwan Gunawan, Heather A. Harris, James C. Keith, Leo M. Albert
  • Substituted 2-phenyl benzofurans as estrogenic agents
    Publication number: 20030171428
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: December 16, 2002
    Publication date: September 11, 2003
    Applicant: Wyeth
    Inventors: Christopher P. Miller, Michael D. Collini, David H. Kaufman, Robert L. Morris, Robert R. Singhaus, John W. Ullrich, Heather A. Harris, James C. Keith, Leo M. Albert, Rayomand J. Unwalla