Abstract: A bioprocessing system comprising a series of processing stations for performing operations for bioprocessing is disclosed. The bioprocessing system includes an automated system comprising means for manipulating a fluid connection between a first container and a separable second container whereby to create an aseptic connection that enables a controlled transfer of fluid or cell material between the first container and the second container, wherein the means for manipulating a fluid connection is configured to create an aseptic connection that can be disconnected after the transfer of fluid or cell material is complete to enable a further such fluid connection to be manipulated between the first container and a separable third container, and means for controlling an automated sequence of operation of the processing stations.

Abstract: An automated system for performing bioprocessing, comprising: an incubation system configured to accommodate at least one incubation chamber for incubating a cell culture chamber having a flexible tube connected fluidly thereto; and a storage system configured to store at least one fluid-containing consumable having a tube connected fluidly thereto; wherein the incubation system and storage system are together arranged to enable a robotic device to manipulate a tube weld between said flexible tube of the incubated cell culture chamber and said tube of the stored consumable, whereby said tube weld forms an aseptic fluid connection between the cell culture chamber and the consumable such that a closed system is maintained.

Abstract: A linear peristaltic pump (200) for a bioprocessing system comprises: at least one pair of jaws formed by a first jaw (201) and a second jaw (202), the first jaw (201) being moveable relative to the second jaw (202) such that the pair of jaws can be moved between an open configuration in which the jaws are spaced apart for receiving a flexible tube (155) therebetween and a closed configuration in which the jaws are brought together so as to retain the tube therebetween; an actuator mechanism configured to control movement of the first jaw relative to the second jaw; and means (220a-220m) for effecting a peristaltic pumping action on a fluid contained within the tube (155) when the tube is retained between the pair of jaws in the closed configuration.

Abstract: A bioprocessing system comprising a series of processing stations for performing operations for bioprocessing is disclosed. The bioprocessing system includes an automated system comprising means for manipulating a fluid connection between a first container and a separable second container whereby to create an aseptic connection that enables a controlled transfer of fluid or cell material between the first container and the second container, wherein the means for manipulating a fluid connection is configured to create an aseptic connection that can be disconnected after the transfer of fluid or cell material is complete to enable a further such fluid connection to be manipulated between the first container and a separable third container, and means for controlling an automated sequence of operation of the processing stations.

Abstract: A system can include a housing that defines an interior space; a shaft disposed at least in part in the interior space of the housing where the shaft includes a longitudinal axis, a curved surface and an end surface; a submersible electric motor operatively coupled to the shaft where the submersible electric motor includes a cable connector; two proximity sensors where each of the proximity sensors includes a sensor aperture disposed in the interior space of the housing; and circuitry operatively coupled to the proximity sensors that determines position values of the shaft with respect to time based at least in part on output of the proximity sensors.

Abstract: A method can include receiving sensor information from at least one sensor disposed in a downhole environment that includes an electric submersible pump operatively coupled to a power drive via a cable; receiving electrical information associated with transmission of power via the cable; and identifying a state of the electric submersible pump via an adaptive model of at least the cable and the electric submersible pump based at least in part on a portion of the sensor information and a portion of the electrical information.

Abstract: A system can include a housing that defines an interior space; a shaft disposed at least in part in the interior space of the housing where the shaft includes a longitudinal axis, a curved surface and an end surface; a submersible electric motor operatively coupled to the shaft where the submersible electric motor includes a cable connector; two proximity sensors where each of the proximity sensors includes a sensor aperture disposed in the interior space of the housing; and circuitry operatively coupled to the proximity sensors that determines position values of the shaft with respect to time based at least in part on output of the proximity sensors.

Abstract: A method can include receiving sensor information from at least one sensor disposed in a downhole environment that includes an electric submersible pump operatively coupled to a power drive via a cable; receiving electrical information associated with transmission of power via the cable; and identifying a state of the electric submersible pump via an adaptive model of at least the cable and the electric submersible pump based at least in part on a portion of the sensor information and a portion of the electrical information.