Abstract: The invention relates to a pharmaceutical composition comprising an SGLT2 inhibitor, a DPPIV inhibitor and a third antidiabetic agent which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.

Abstract: This invention relates to binding molecules that bind specifically Vascular Endothelial Growth Factor (VEGF) and Tropomyosin receptor kinase B (TrkB) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of diseases of the eye.

Abstract: The present invention relates to the medical use of specific long-acting glucagon analogues having dual GLP-1/glucagon receptor agonist activity in the prevention and/or treatment of metabolic liver disease, particularly non-alcoholic fatty liver disease (NAFLD), non-alcoholic fatty liver (NAFL), non-alcoholic steatohepatitis (NASH), NAFLD-associated liver fibrosis and/or cirrhosis.

Abstract: The invention relates to cyclopentathiophene carboxamides of formula (I.0) wherein R1, R2, R3, R4, and n are as defined herein, and pharmaceutically acceptable salts thereof. The invention also relates to the use of the cyclopentathiophene carboxamides of formula (I.0) for the treatment of diseases which can be influenced by antagonizing the activity mediated by the platelet activating factor receptor.

Abstract: Disclosed are antibodies and fragments thereof that target the A-domain of Neuropilin-1 (Nrp1A). Also disclosed are methods of using the anti-Nrp1A antibodies for the treatment of various diseases or disorders.

Abstract: The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel acylated glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.

Abstract: The present invention relates to antibodies and fragments thereof that target semaphorin 3A (Sema3A). More specifically, anti-Sema3A antibodies and methods of use for the treatment of various diseases or disorders are disclosed.

Abstract: A system or method for manipulating audiovisual data using transcript information. The system or method performs the following actions. Creating a computer-generated transcript of audio data from the audiovisual data, the computer-generated transcript includes a plurality of words, at least some words of the plurality of words are associated with a respective timestamp and a confidence score. Receiving a traditional transcript of the audio data, the traditional transcript includes a plurality of words that are not associated with timestamps. Identifying one or more words from the plurality of words of the computer-generated transcript that match words from the plurality of words of the traditional transcript. Associating the timestamp of the one or more words of the computer-generated transcript with the matching word of the traditional transcript. Processing the audiovisual data using the traditional transcript and the associated timestamps.

Abstract: A system or method for aligning in time a first transcript to audio data used to create the first transcript. The system or method performs the following actions. Receiving the first transcript. The first transcript includes a first plurality of words that are in the audio data. Transcribing the audio data to make a second transcript. The second transcript includes a second plurality of words that are in the audio data and a respective time of a location in the audio data of each word of the second plurality. For each word of the second plurality found in the first plurality, assigning the respective time of the location of the word of the second plurality to the word of the first plurality thereby aligning in time the first transcript to the audio data.

Abstract: The invention relates to a pharmaceutical composition according to the claim 1 comprising an SGLT2 inhibitor, a DPPIV inhibitor and a third antidiabetic agent which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.

Abstract: The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel acylated glucagon analog peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.

Abstract: A system or method for manipulating audiovisual data using transcript information. The system or method performs the following actions. Creating a computer-generated transcript of audio data from the audiovisual data, the computer-generated transcript includes a plurality of words, at least some words of the plurality of words are associated with a respective timestamp and a confidence score. Receiving a traditional transcript of the audio data, the traditional transcript includes a plurality of words that are not associated with timestamps. Identifying one or more words from the plurality of words of the computer-generated transcript that match words from the plurality of words of the traditional transcript. Associating the timestamp of the one or more words of the computer-generated transcript with the matching word of the traditional transcript. Processing the audiovisual data using the traditional transcript and the associated timestamps.

Abstract: Various embodiments are generally directed to systems for designing, generating, and/or creating maintenance arrangements for repairable systems in an interactive workspace, such as for computer simulation of maintenance events. Some embodiments are particularly directed to an interactive workspace that enables assignments and intuitive modeling of a maintenance arrangement associated with one or more components in a reliability block diagram (RBD). In embodiments, a system maintenance arrangement for one or more components of the RBD may be generated in a diagram workspace by associating events selected from an event menu with one or more components in an RBD; and by associating actions selected from an action menu with one or more events via the addition of linking elements. In such embodiments, resolution of an occurrence of an event, such as during a computer simulation, may depend on performance or simulated performance of the actions associated with the event via linking elements.

Abstract: The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel glucagon analog peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.

Abstract: The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel glucagon analog peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.

Abstract: A system or method for manipulating audiovisual data using transcript information. The system or method performs the following actions. Creating a computer-generated transcript of audio data from the audiovisual data, the computer-generated transcript includes a plurality of words, at least some words of the plurality of words are associated with a respective timestamp and a confidence score. Receiving a traditional transcript of the audio data, the traditional transcript includes a plurality of words that are not associated with timestamps. Identifying one or more words from the plurality of words of the computer-generated transcript that match words from the plurality of words of the traditional transcript. Associating the timestamp of the one or more words of the computer-generated transcript with the matching word of the traditional transcript. Processing the audiovisual data using the traditional transcript and the associated timestamps.

Abstract: A system or method for aligning in time a first transcript to audio data used to create the first transcript. The system or method performs the following actions. Receiving the first transcript. The first transcript includes a first plurality of words that are in the audio data. Transcribing the audio data to make a second transcript. The second transcript includes a second plurality of words that are in the audio data and a respective time of a location in the audio data of each word of the second plurality. For each word of the second plurality found in the first plurality, assigning the respective time of the location of the word of the second plurality to the word of the first plurality thereby aligning in time the first transcript to the audio data.

Abstract: Various embodiments are generally directed to systems for designing, generating, and/or creating maintenance arrangements for repairable systems in an interactive workspace, such as for computer simulation of maintenance events. Some embodiments are particularly directed to an interactive workspace that enables assignments and intuitive modeling of a maintenance arrangement associated with one or more components in a reliability block diagram (RBD). In embodiments, a system maintenance arrangement for one or more components of the RBD may be generated in a diagram workspace by associating events selected from an event menu with one or more components in an RBD; and by associating actions selected from an action menu with one or more events via the addition of linking elements. In such embodiments, resolution of an occurrence of an event, such as during a computer simulation, may depend on performance or simulated performance of the actions associated with the event via linking elements.

Abstract: The present invention relates to compounds defined by formula I wherein the groups X, Y, W and R1 to R4 are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are agonists of the 5-HT2C receptor, and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this receptor, such as metabolic and CNS-related disorders.

Abstract: The invention is directed to the use of selected purine derivatives for the treatment of hyperproliferative diseases.