Patents by Inventor Leo Thomas

Leo Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12115179
    Abstract: The invention relates to a pharmaceutical composition comprising an SGLT2 inhibitor, a DPPIV inhibitor and a third antidiabetic agent which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.
    Type: Grant
    Filed: May 19, 2023
    Date of Patent: October 15, 2024
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Peter Eickelmann, Michael Mark, Leo John Seman, Leo Thomas, Uli Christian Broedl, Rolf Grempler
  • Patent number: 12110335
    Abstract: This invention relates to binding molecules that bind specifically Vascular Endothelial Growth Factor (VEGF) and Tropomyosin receptor kinase B (TrkB) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of diseases of the eye.
    Type: Grant
    Filed: October 20, 2021
    Date of Patent: October 8, 2024
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Peter Michael Benz, Remko Alexander Bakker, Holger Fuchs, Fei Han, Sandeep Kumar, Sarah Low, Justin M. Scheer, Leo Thomas
  • Patent number: 11813312
    Abstract: The present invention relates to the medical use of specific long-acting glucagon analogues having dual GLP-1/glucagon receptor agonist activity in the prevention and/or treatment of metabolic liver disease, particularly non-alcoholic fatty liver disease (NAFLD), non-alcoholic fatty liver (NAFL), non-alcoholic steatohepatitis (NASH), NAFLD-associated liver fibrosis and/or cirrhosis.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: November 14, 2023
    Assignee: Boehringer Ingelheim International GmbH
    Inventor: Leo Thomas
  • Patent number: 11766443
    Abstract: The invention relates to cyclopentathiophene carboxamides of formula (I.0) wherein R1, R2, R3, R4, and n are as defined herein, and pharmaceutically acceptable salts thereof. The invention also relates to the use of the cyclopentathiophene carboxamides of formula (I.0) for the treatment of diseases which can be influenced by antagonizing the activity mediated by the platelet activating factor receptor.
    Type: Grant
    Filed: November 12, 2021
    Date of Patent: September 26, 2023
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthias Eckhardt, Marina Kristina Willwacher, Juergen Prestle, Ferenc Kontes, Leo Thomas, Christofer Siegfried Tautermann, Dieter Wiedenmayer
  • Patent number: 11661458
    Abstract: Disclosed are antibodies and fragments thereof that target the A-domain of Neuropilin-1 (Nrp1A). Also disclosed are methods of using the anti-Nrp1A antibodies for the treatment of various diseases or disorders.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: May 30, 2023
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Nina Zippel, Pankaj Gupta, Fei Han, Sarah Low, Juergen Prestle, Leo Thomas
  • Patent number: 11274136
    Abstract: The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel acylated glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: March 15, 2022
    Assignee: Zealand Pharma A/S
    Inventors: Ditte Riber, Jakob Lind Tolborg, Dieter Wolfgang Hamprecht, Leo Thomas
  • Patent number: 11267880
    Abstract: The present invention relates to antibodies and fragments thereof that target semaphorin 3A (Sema3A). More specifically, anti-Sema3A antibodies and methods of use for the treatment of various diseases or disorders are disclosed.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: March 8, 2022
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Leo Thomas, Rachel Rebecca Barrett, Kristin Laura Bovat, Rajkumar Ganesan, Priyanka Gupta, Fei Han, Dongmei Liu, Juergen Prestle, Sanjaya Singh, Sathyadevi Venkataramani, Helen Haixia Wu, Nina Zippel
  • Patent number: 10943600
    Abstract: A system or method for manipulating audiovisual data using transcript information. The system or method performs the following actions. Creating a computer-generated transcript of audio data from the audiovisual data, the computer-generated transcript includes a plurality of words, at least some words of the plurality of words are associated with a respective timestamp and a confidence score. Receiving a traditional transcript of the audio data, the traditional transcript includes a plurality of words that are not associated with timestamps. Identifying one or more words from the plurality of words of the computer-generated transcript that match words from the plurality of words of the traditional transcript. Associating the timestamp of the one or more words of the computer-generated transcript with the matching word of the traditional transcript. Processing the audiovisual data using the traditional transcript and the associated timestamps.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: March 9, 2021
    Assignee: Axon Enterprise, Inc.
    Inventors: Joseph Charles Dimino, Jr., Sayce William Falk, Leo Thomas Rossignac-Milon
  • Patent number: 10755729
    Abstract: A system or method for aligning in time a first transcript to audio data used to create the first transcript. The system or method performs the following actions. Receiving the first transcript. The first transcript includes a first plurality of words that are in the audio data. Transcribing the audio data to make a second transcript. The second transcript includes a second plurality of words that are in the audio data and a respective time of a location in the audio data of each word of the second plurality. For each word of the second plurality found in the first plurality, assigning the respective time of the location of the word of the second plurality to the word of the first plurality thereby aligning in time the first transcript to the audio data.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: August 25, 2020
    Assignee: Axon Enterprise, Inc.
    Inventors: Joseph Charles Dimino, Jr., Sayce William Falk, Leo Thomas Rossignac-Milon
  • Patent number: 10406172
    Abstract: The invention relates to a pharmaceutical composition according to the claim 1 comprising an SGLT2 inhibitor, a DPPIV inhibitor and a third antidiabetic agent which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: September 10, 2019
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Peter Eickelmann, Michael Mark, Leo John Seman, Leo Thomas, Uli Broedl, Rolf Grempler
  • Patent number: 10336802
    Abstract: The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel acylated glucagon analog peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: July 2, 2019
    Assignee: Zealand Pharma A/S
    Inventors: Ditte Riber, Jakob Lind Tolborg, Dieter Wolfgang Hamprecht, Leo Thomas
  • Publication number: 20190198038
    Abstract: A system or method for manipulating audiovisual data using transcript information. The system or method performs the following actions. Creating a computer-generated transcript of audio data from the audiovisual data, the computer-generated transcript includes a plurality of words, at least some words of the plurality of words are associated with a respective timestamp and a confidence score. Receiving a traditional transcript of the audio data, the traditional transcript includes a plurality of words that are not associated with timestamps. Identifying one or more words from the plurality of words of the computer-generated transcript that match words from the plurality of words of the traditional transcript. Associating the timestamp of the one or more words of the computer-generated transcript with the matching word of the traditional transcript. Processing the audiovisual data using the traditional transcript and the associated timestamps.
    Type: Application
    Filed: February 28, 2019
    Publication date: June 27, 2019
    Inventors: Joseph Charles DIMINO, JR., Sayce William FALK, Leo Thomas ROSSIGNAC-MILON
  • Patent number: 10282062
    Abstract: Various embodiments are generally directed to systems for designing, generating, and/or creating maintenance arrangements for repairable systems in an interactive workspace, such as for computer simulation of maintenance events. Some embodiments are particularly directed to an interactive workspace that enables assignments and intuitive modeling of a maintenance arrangement associated with one or more components in a reliability block diagram (RBD). In embodiments, a system maintenance arrangement for one or more components of the RBD may be generated in a diagram workspace by associating events selected from an event menu with one or more components in an RBD; and by associating actions selected from an action menu with one or more events via the addition of linking elements. In such embodiments, resolution of an occurrence of an event, such as during a computer simulation, may depend on performance or simulated performance of the actions associated with the event via linking elements.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: May 7, 2019
    Assignee: SAS INSTITUTE INC.
    Inventors: Peng Liu, Leo Thomas Wright, Jr.
  • Patent number: 10253081
    Abstract: The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel glucagon analog peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: April 9, 2019
    Assignee: Zealand Pharma A/S
    Inventors: Jakob Lind Tolborg, Keld Fosgerau, Pia Nørregaard, Rasmus Just, Ditte Riber, Dieter Wolfgang Hamprecht, Robert Augustin, Leo Thomas, Wolfgang Rist
  • Patent number: 9975939
    Abstract: The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel glucagon analog peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: May 22, 2018
    Assignee: Zealand Pharma A/S
    Inventors: Jakob Lind Tolborg, Keld Fosgerau, Pia Nørregaard, Rasmus Just, Ditte Riber, Dieter Wolfgang Hamprecht, Robert Augustin, Leo Thomas, Wolfgang Rist
  • Publication number: 20180130484
    Abstract: A system or method for manipulating audiovisual data using transcript information. The system or method performs the following actions. Creating a computer-generated transcript of audio data from the audiovisual data, the computer-generated transcript includes a plurality of words, at least some words of the plurality of words are associated with a respective timestamp and a confidence score. Receiving a traditional transcript of the audio data, the traditional transcript includes a plurality of words that are not associated with timestamps. Identifying one or more words from the plurality of words of the computer-generated transcript that match words from the plurality of words of the traditional transcript. Associating the timestamp of the one or more words of the computer-generated transcript with the matching word of the traditional transcript. Processing the audiovisual data using the traditional transcript and the associated timestamps.
    Type: Application
    Filed: August 15, 2017
    Publication date: May 10, 2018
    Inventors: Joseph Charles Dimino, JR., Sayce William FALK, Leo Thomas ROSSIGNAC-MILON
  • Publication number: 20180130483
    Abstract: A system or method for aligning in time a first transcript to audio data used to create the first transcript. The system or method performs the following actions. Receiving the first transcript. The first transcript includes a first plurality of words that are in the audio data. Transcribing the audio data to make a second transcript. The second transcript includes a second plurality of words that are in the audio data and a respective time of a location in the audio data of each word of the second plurality. For each word of the second plurality found in the first plurality, assigning the respective time of the location of the word of the second plurality to the word of the first plurality thereby aligning in time the first transcript to the audio data.
    Type: Application
    Filed: August 15, 2017
    Publication date: May 10, 2018
    Inventors: Joseph Charles DIMINO, JR., Sayce William FALK, Leo Thomas ROSSIGNAC-MILON
  • Publication number: 20180095619
    Abstract: Various embodiments are generally directed to systems for designing, generating, and/or creating maintenance arrangements for repairable systems in an interactive workspace, such as for computer simulation of maintenance events. Some embodiments are particularly directed to an interactive workspace that enables assignments and intuitive modeling of a maintenance arrangement associated with one or more components in a reliability block diagram (RBD). In embodiments, a system maintenance arrangement for one or more components of the RBD may be generated in a diagram workspace by associating events selected from an event menu with one or more components in an RBD; and by associating actions selected from an action menu with one or more events via the addition of linking elements. In such embodiments, resolution of an occurrence of an event, such as during a computer simulation, may depend on performance or simulated performance of the actions associated with the event via linking elements.
    Type: Application
    Filed: October 3, 2017
    Publication date: April 5, 2018
    Applicant: SAS Institute Inc.
    Inventors: Peng Liu, Leo Thomas Wright, JR.
  • Patent number: 9346816
    Abstract: The present invention relates to compounds defined by formula I wherein the groups X, Y, W and R1 to R4 are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are agonists of the 5-HT2C receptor, and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this receptor, such as metabolic and CNS-related disorders.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: May 24, 2016
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Stephan-Georg Mueller, Christopher John Brown, Alexander Heifetz, Bernd Nosse, Juergen Prestle, Natacha Prevost, Klaus Rudolf, Stefan Scheuerer, Marcus Schindler, Dirk Stenkamp, Leo Thomas, Heather Tye
  • Publication number: 20160136180
    Abstract: The invention is directed to the use of selected purine derivatives for the treatment of hyperproliferative diseases.
    Type: Application
    Filed: January 20, 2016
    Publication date: May 19, 2016
    Inventors: Frank Himmelsbach, Michael Mark, Mohammad Tadayyon, Leo Thomas