Patents by Inventor Leo Timothy Laughlin, II

Leo Timothy Laughlin, II has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210401818
    Abstract: The present invention is directed to a personal composition comprising a) a strobilurin; b) a 2-pyridinol-N-oxide material wherein the ratio of a:b is from about 10:1 to about 1:20; wherein there is a synergistic anti-inflammatory/cellular stress activity.
    Type: Application
    Filed: December 18, 2020
    Publication date: December 30, 2021
    Inventors: Jeanette Anthea Richards, James Robert Schwartz, Leo Timothy Laughlin, II, Geoffrey Marc Wise, Eric Scott Johnson
  • Publication number: 20210299206
    Abstract: A natural vaginal care composition is provided. The natural composition includes a biobased vaginal care agent; a biobased thickener; and at least 60% water. The natural composition may optionally include a biobased preservative, a biobased emulsifier, and a biobased pH adjuster. The natural vaginal care composition is suitable for treating symptoms of vaginal atrophy and/or dryness.
    Type: Application
    Filed: December 9, 2020
    Publication date: September 30, 2021
    Inventors: Travis Kyle HODGDON, Leo Timothy LAUGHLIN, II, Samantha Chen-Yee WANG
  • Publication number: 20210283131
    Abstract: The present invention is directed to a personal care composition comprising a) azoxystrobin; b) a 2-pyridinol-N-oxide material wherein the ratio of a:b is from about 4:1 to about 1:50; wherein there is a synergistic anti-inflammatory/cellular stress activity.
    Type: Application
    Filed: June 26, 2020
    Publication date: September 16, 2021
    Inventors: Jeanette Anthea Richards, James Robert Schwartz, II, Leo Timothy Laughlin, II, Geoffrey Marc Wise, Eric Scott Johnson
  • Patent number: 10925823
    Abstract: The present invention discloses to a personal care composition having a polyvalent metal salt of pyrithione; a 2-pyridinol-N-oxide material; and a zinc containing layered material; wherein the ratio of a:b is from about 0.5 to about 1.5; the ratio of b:c is about 0.2 to about 1.0; and the ratio of a:c is about 0.2 to about 1.0 and wherein there is a synergistic antioxidant activity.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: February 23, 2021
    Assignee: The Procter and Gamble Company
    Inventors: James Robert Schwartz, Leo Timothy Laughlin, II, Lijuan Li, Junjun Chen, Kathleen Marie Kerr
  • Publication number: 20210038632
    Abstract: A method of treating vaginal atrophy is provided. The method comprises administering a vaginal care composition to vaginal tissue of a user experiencing a symptom of vaginal atrophy. The vaginal care composition may include an effective amount of a vaginal care agent selected to specifically treat symptoms of vaginal atrophy exhibited by the introitus and/or labia, based on the transcriptomic data of skin cells obtained therefrom. In some instances, the vaginal care composition may be applied to introitus and/or labia with a suitable implement configured for such use.
    Type: Application
    Filed: October 27, 2020
    Publication date: February 11, 2021
    Inventors: Travis Kyle HODGDON, Leo Timothy LAUGHLIN, II, Samantha Chen-Yee WANG, Robert Lloyd BINDER
  • Publication number: 20210038665
    Abstract: This disclosure relates to a supplement, particularly a supplement for menopause.
    Type: Application
    Filed: October 26, 2020
    Publication date: February 11, 2021
    Inventors: Jesus VELAZQUEZ, Leo Timothy LAUGHLIN, II, Brian Kenneth BURGDORF
  • Publication number: 20210038679
    Abstract: A method of treating vaginal dryness by administering a vaginal care composition, which includes an effective amount of a vaginal care agent, to vaginal tissue of a user experiencing vaginal dryness. The vaginal care agent may be selected to specifically treat symptoms of vaginal dryness exhibited by the introitus and/or labia, based on the transcriptomic data of skin cells obtained therefrom. In some instances, the vaginal care composition may be applied to introitus and/or labia with a suitable implement configured for such use.
    Type: Application
    Filed: October 27, 2020
    Publication date: February 11, 2021
    Inventors: Travis Kyle HODGDON, Leo Timothy LAUGHLIN, II, Samantha Chen-Yee WANG, Robert Lloyd BINDER
  • Publication number: 20200405614
    Abstract: Methods and compositions for improving the appearance of skin are provided. The methods and compositions are especially suited for inhibiting activation of PAR2 in skin by utilizing a synergistic combination of a water lily extract and vitamin B3 compound. The method involves treating hyperpigmented skin by applying a skin care composition containing an effective amount of a combination of water lily extract and vitamin B3 compound to a target portion of skin over the course of a treatment period.
    Type: Application
    Filed: June 28, 2019
    Publication date: December 31, 2020
    Inventors: Tomohiro HAKOZAKI, Bin FANG DEYER, Leo Timothy LAUGHLIN, II
  • Patent number: 10849948
    Abstract: This disclosure relates to a supplement, particularly a supplement for menopause.
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: December 1, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Jesus Velazquez, Leo Timothy Laughlin, II, Brian Kenneth Burgdorf
  • Publication number: 20200330536
    Abstract: This disclosure relates to a supplement, particularly a supplement for menopause.
    Type: Application
    Filed: April 16, 2019
    Publication date: October 22, 2020
    Inventors: Jesus VELAZQUEZ, Leo Timothy LAUGHLIN, II, Brian Kenneth BURGDORF
  • Publication number: 20200138764
    Abstract: Treatment for excess adipose tissue by applying an activating compound directly to a targeted area. The activating compound is a cyclohexanecarboxamide derivative. The activating compound promotes thermogenesis in cells to generate heat.
    Type: Application
    Filed: November 7, 2019
    Publication date: May 7, 2020
    Inventors: Jose Mauro Goulart BRUM, Nicholas William GEARY, John Christian HAUGHT, Bhavani KASIBHATLA, Leo Timothy LAUGHLIN, II, Koti Tatachar SREEKRISHNA, John August WOS, Kenneth Edward YELM
  • Publication number: 20200009123
    Abstract: An improved method of treating a skin barrier condition is disclosed. The method involves identifying a target portion of skin on a person where treatment is desired and applying a low-pH composition to the target portion of skin. The low-pH composition contains an effective amount of a vitamin B3 compound and has a pH of less than 5.0.
    Type: Application
    Filed: July 2, 2019
    Publication date: January 9, 2020
    Inventors: Tomohiro HAKOZAKI, Leo Timothy LAUGHLIN, II, Jason Martin WINGET
  • Publication number: 20190362813
    Abstract: An improved connectivity mapping method for identifying connections between a potential skin care agent associated with an instance and genes associated with a skin hyperpigmentation condition. The system includes a non-transitory computer readable medium having a plurality of instances stored thereon, and a biased gene expression signature associated with a skin condition. The biased condition signature is constructed by filtering an unbiased condition signature through a benchmark signature.
    Type: Application
    Filed: May 22, 2019
    Publication date: November 28, 2019
    Inventors: Wenzhu NMN ZHAO, Tomohiro NMN HAKOZAKI, Leo Timothy LAUGHLIN, II
  • Publication number: 20190350831
    Abstract: The present invention discloses to a personal care composition having a polyvalent metal salt of pyrithione; a 2-pyridinol-N-oxide material; and a zinc containing layered material; wherein the ratio of a:b is from about 0.5 to about 1.5; the ratio of b:c is about 0.2 to about 1.0; and the ratio of a:c is about 0.2 to about 1.0 and wherein there is a synergistic antioxidant activity.
    Type: Application
    Filed: May 15, 2019
    Publication date: November 21, 2019
    Inventors: James Robert Schwartz, Leo Timothy Laughlin, II, Lijuan Li, Junjun Chen, Kathleen Marie Kerr
  • Patent number: 10267796
    Abstract: Embodiments of screening methods for determining test agents effective for modifying the appearance of pigmented skin are provided. The screening method may comprise the steps of contacting a cell, a cell culture, or bulk cells with the test agent, wherein the cell, the cell culture, or the bulk cells comprise ADR?1 receptors, and determining based on the binding interaction of the test agent with the ADR?1 receptors whether the test agent is an effective ADR?1 receptor antagonist suitable for modifying the appearance of pigmented skin, wherein a test agent is considered to be an effective ADR?1 receptor antagonist when it defines a half maximal inhibitory concentration of less than about 1000 ppm.
    Type: Grant
    Filed: October 21, 2011
    Date of Patent: April 23, 2019
    Assignee: The Procter & Gamble Company
    Inventors: Leo Timothy Laughlin, II, Tomohiro Hakozaki, Wenzhu Zhao, Jiazhen Wang, John Crist Bierman
  • Patent number: 10054582
    Abstract: A method of identifying a test agent as a skin tone agent. The method includes determining the level of high-mobility group protein B1 (HMGB1), messenger RNA associated with the expression and/or regulation of HMGB1 (HMGB1 mRNA), and/or micro-RNA associated with the expression and/or regulation of HMGB1 (HMGB1 miRNA) present in the test sample, and identifying the test agent as a skin tone agent when there is no increase in HMGB1 level, a downregulation in transcription of HMGB1 mRNA, and/or an upregulation of HMGB1 miRNA. The method also includes identifying a test agent as a skin tone agent when the test agent inhibits or prevents an increase in melanocyte dendricity and/or body size caused by HMGB1.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: August 21, 2018
    Assignee: The Procter & Gamble Company
    Inventors: Leo Timothy Laughlin, II, Tomohiro Hakozaki, Wenzhu Zhao
  • Patent number: 9964534
    Abstract: A method of making a skin composition that includes an effective amount of skin care agent selected to inhibit HMGB1 stimulation of human melanocytes. The method includes determining the level of high-mobility group protein B1 (HMGB1), messenger RNA associated with the expression and/or regulation of HMGB1 (HMGB1 mRNA), and/or micro-RNA associated with the expression and/or regulation of HMGB1 (HMGB1 miRNA) present in the test sample, and identifying the test agent as a skin tone agent when there is no increase in HMGB1 level, a downregulation in transcription of HMGB1 mRNA, and/or an upregulation of HMGB1 miRNA. The method also includes identifying a test agent as a skin tone agent when the test agent inhibits or prevents an increase in melanocyte dendricity and/or body size caused by HMGB1, and incorporating the skin tone agent in a dermatologically acceptable carrier.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: May 8, 2018
    Assignee: The Procter & Gamble Company
    Inventors: Leo Timothy Laughlin, II, Tomohiro Hakozaki, Wenzhu Zhao
  • Patent number: 9757317
    Abstract: A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include bisabolol, undecylenoyl phenylalanine and/or hexyldecanol, and a material selected from the group consisting of ethyl palmitate, stearyl alcohol, bis (2-ethylhexyl) adipate, bis (2-ethylhexyl) maleate, 5-pentadecanol, 1-stearoyl-rac-glycerol, bis (2-ethylhexyl) sebacate, and mixtures thereof. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: September 12, 2017
    Assignee: The Procter & Gamble Company
    Inventors: Leo Timothy Laughlin, II, Tomohiro Hakozaki, Shikhar Gupta
  • Patent number: 9597271
    Abstract: A cosmetic composition for topical application to skin is provided. The cosmetic composition includes vitamin B3 compound, a ricinoleate compound and a dermatologically acceptable carrier. The vitamin B3 compound and the ricinoleate beneficially or even synergistically up-regulate proteasomal protease activity as evidenced by a higher observed net luminescence value relative to the calculated net luminescence value in B16 melanoma cells.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: March 21, 2017
    Assignee: The Procter & Gamble Company
    Inventors: Tomohiro Hakozaki, Leo Timothy Laughlin, II, Michael Christopher Sabino
  • Patent number: 9498420
    Abstract: A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include batyl alcohol, undecylenoyl phenylalanine, hexyldecanol, and bisabolol. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: November 22, 2016
    Assignee: The Procter & Gamble Company
    Inventors: Leo Timothy Laughlin, II, Tomohiro Hakozaki, Shuhei Tanaka