Abstract: An antibody production process in mammalian cells in which engineered unpaired cysteine residues are post-translationally modified and capped with particular chemical entities, which capped antibodies are well suited to further site-specific conjugation steps to form antibody-drug conjugates (ADCs) or protein drug conjugates; ADCs produced using these capped antibodies including in particular ADCs formed by the selective reduction of the capped antibodies' cysteine residues, and ADCs formed using chemical handles such as aldehyde/azide/alkyne biorthogonal groups, which permit additional drug conjugation chemistry; and uncapped antibodies produced by cells in low cysteine, cysteine and glutathione media, and ADCs produced via direct conjugation to these uncapped antibodies.

Abstract: Vehicles may have autonomous capabilities that permit the vehicle to navigate according to varying levels of participation by a human operator. A human operator may be associated with a driving capability profile and the environment surrounding a vehicle may be associated with an environmental risk profile. A vehicle, or another party in communication with a vehicle, may determine whether, based on the human operator's driving capability profile and the environmental risk profile, it is likely that the vehicle will be navigated more safely if there is a change to the vehicle's autonomous capabilities and a corresponding change to the human operator's driving responsibilities. If it is determined that a change in autonomous vehicle capability is likely to increase safe navigation of the vehicle, an insurer may offer an insurance premium cost reduction if the human operator agrees to the proposed change in autonomous capabilities.

Abstract: A medical implant is disclosed. The medical implant includes a body having a first end having a first cross-sectional dimension, a second end having a second cross-sectional dimension, and a tapered portion extending between the first end and the second end. The first cross-sectional dimension is larger than the second cross-sectional dimension. In some embodiments, the body comprises multiple layers.

Abstract: A device and the method of installing and adjusting same, which provides reduction of glare from overhead lighting, including but not limited to “can” lighting, also referred to as recessed lighting.

Abstract: Crystalline zeolites having a FER framework type wherein the crystallites have a dimension in the c-axis of about 500 nanometers (nm) or less, a method for their preparation and a process for the co-production of acetic acid and dimethyl ether comprising the step of contacting methyl acetate and methanol in the presence of catalysts comprising the crystalline zeolites.

Abstract: Crystalline zeolites having a FER framework type wherein the crystallites have a dimension in the c-axis of about 500 nanometres (nm) or less, a method for their preparation and a process for the co-production of acetic acid and dimethyl ether comprising the step of contacting methyl acetate and methanol in the presence of catalysts comprising the crystalline zeolites.

Abstract: Process for the co-production of acetic acid and dimethyl ether by contacting methyl acetate and methanol in the presence of a catalyst containing a crystalline zeolite having a FER framework type. The zeolite has crystallites having a dimension of about 500 nm or less in the c-axis.

Abstract: A system for verifiably locking a first cylindrical component to a second cylindrical component in a safe and secure manner. The system provides a visible indication when the first component and second component are fully and effectively secured. The first cylindrical component comprises a lock cylinder fixedly attached to the first cylindrical component. The lock cylinder comprises a lock piston. The second cylindrical component comprises a channel with a guide region and a lock region. The visible portion of the lock piston provides an indication of whether or not the lock piston is secured in the lock region of the channel. The system is also capable of being operated from a control panel to operate the locks, receive signals from sensors, and to display the lock status of the system. The system offers redundant verifications to enhance safety in operating environments.

Abstract: A hand tool assembly, such as a push broom, includes an elongated work head defining a width and having a slot formed therein extending in a direction along the width. A handle includes an end portion slidably mounted in the slot such that the end portion is movable between a first position and a second position. A fastening mechanism releasably secures the end portion of the handle to the work head when the end portion is in the first position.

Abstract: Process for the co-production of acetic acid and dimethyl ether products from a mixture of methanol and methyl acetate by contacting the mixture at a temperature from 200 to 260° C., with a catalyst composition containing a zeolite possessing a 2-dimensional channel system. The catalyst system contains at least one channel having a 10-membered ring and a silica:alumina molar ratio of at least 22:1.

Abstract: A system for verifiably locking a first cylindrical component to a second cylindrical component in a safe and secure manner. The system provides a visible indication when the first component and second component are fully and effectively secured. The first cylindrical component comprises a lock cylinder fixedly attached to the first cylindrical component. The lock cylinder comprises a lock piston. The second cylindrical component comprises a channel with a guide region and a lock region. The visible portion of the lock piston provides an indication of whether or not the lock piston is secured in the lock region of the channel. The system is also capable of being operated from a control panel to operate the locks, receive signals from sensors, and to display the lock status of the system. The system offers redundant verifications to enhance safety in operating environments.

Abstract: Crystalline zeolites having a FER framework type wherein the crystallites have a dimension in the c-axis of about 500 nanometres (nm) or less, a method for their preparation and a process for the co-production of acetic acid and dimethyl ether comprising the step of contacting methyl acetate and methanol in the presence of catalysts comprising the crystalline zeolites.

Abstract: A process for the co-production of acetic acid and dimethyl ether products from a mixture of methanol and methyl acetate by contacting the mixture at a temperature from 200 to 260° C., with a catalyst composition comprising a zeolite possessing a 2-dimensional channel system comprising at least one channel having a 10-membered ring and a silica:alumina molar ratio of at least 22:1.

Abstract: A hand tool assembly, such as a push broom, includes an elongated work head defining a width and having a slot formed therein extending in a direction along the width. A handle includes an end portion slidably mounted in the slot such that the end portion is movable between a first position and a second position. A fastening mechanism releasably secures the end portion of the handle to the work head when the end portion is in the first position.

Abstract: A method and system for rapid containment and intervention of a subsea well blowout that can be performed in a rapid and efficient manner, where containment will minimize the damage to the environment and assets. The method can include disconnecting a riser from a subsea well after a blowout has occurred and moving the mobile offshore drilling unit away from the subsea well. Connecting a lower marine riser package with a blowout preventer, and diverting the well. The pressure and flow of the well fluid can be observed. At least of portion of the diversion path can be closed off and kill fluid and or cement pumped to the subsea well to kill and control the well.

Abstract: Disclosed is a non-interrupt meter change out device including a clamp assembly, at least one case assembly, and at least one collar, the clamp assembly including a frame and a distance adjuster.

Abstract: A method and system for rapid containment and intervention of a subsea well blowout that can be performed in a rapid and efficient manner, where containment will minimize the damage to the environment and assets. The method can include disconnecting a riser from a subsea well after a blowout has occurred and moving the mobile offshore drilling unit away from the subsea well. Connecting a lower marine riser package with a blowout preventer, and diverting the well. The pressure and flow of the well fluid can be observed. At least of portion of the diversion path can be closed off and kill fluid and or cement pumped to the subsea well to kill and control the well.

Abstract: Disclosed is a non-interrupt meter change out device including a clamp assembly, at least one case assembly, and at least one collar, the clamp assembly including a frame and a distance adjuster.

Abstract: A process for reacting in a fluid bed reactor at least one oxidisable reactant with molecular oxygen in the presence of a catalytically active fluidised bed of solid particles. In the process a molecular oxygen-containing gas having an oxygen concentration greater than that of air is introduced into the fluidised bed whilst the fluidised bed is maintained in a turbulent regime. The process is suitable for oxidation, ammoxidation and carboxylation processes, including the production of maleic anhydride, acrylonitrile, ethylene, acetic acid and vinyl acetate.

Abstract: An oxidation process for the production of alkenes and carboxylic acids from a feed comprising alkene and/or alkane, carbon monoxide, a molecular oxygen containing gas and optionally water in the presence of an oxidation catalyst in which the level of carbon monoxide is maintained between 1% and 20% by volume of the total feed to the reactor.