Patents by Inventor Leon Bradlow

Leon Bradlow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Formulation for administration of steroid compounds
    Patent number: 5824668
    Abstract: Disclosed are compositions including at least one 5.beta. steroid and an amorphous cyclodextrin. Also disclosed are methods for treating a condition such as obesity, diabetes syndrome, diabetes-associated hypercorticoidism, combinations thereof, and anemic disorders by administering to a mammal in need of such treatment a composition including an obesity-, diabetes-, or anemia antagonistic amount of at least one 5.beta. steroid and an amorphous cyclodextrin. Furthermore, disclosed are methods for treating a subject for a condition that responds to treatment with DHEA by administering to the subject at least one 5.beta. steroid and DHEA in an amount that minimizes the contribution of the DHEA to the production of testosterone and estradiol while maximizing an amount of .alpha.ET and .beta.ET circulating in the subject's blood from an initial dose administered to the subject.
    Type: Grant
    Filed: November 7, 1996
    Date of Patent: October 20, 1998
    Assignee: Supergen, Inc.
    Inventors: Joseph Rubinfeld, Julius A. Vida, H. Leon Bradlow, Elliott L. Fineman
  • Diagnostic assay for breast cancer in human female patients
    Patent number: 5130256
    Abstract: A method for determining whether a woman with gross cystic disease will develop breast cancer is provided. The method comprises analyzing human breast cyst fluid for the presence of a unique factor which has a retention time on an Amino Carbohydrate HPLC column of between about 6.4 minutes and about 6.7 minutes. The presence of this factor is diagnostically predictive for breast cancer.
    Type: Grant
    Filed: August 23, 1991
    Date of Patent: July 14, 1992
    Assignee: Long Island Jewish Medical Center
    Inventors: Fred I. Chasalow, H. Leon Bradlow
  • Biologically active agent having antihypertensive activity in mammals
    Patent number: 5122371
    Abstract: A biologically active agent extracted from female breast cyst fluids displays anti-hypertensive activity in mammals. The agent is also useful in the treatment of congestive heart disease, artial fibrillation and idiopathic edema in mammals.
    Type: Grant
    Filed: March 6, 1991
    Date of Patent: June 16, 1992
    Inventors: Fred I. Chaslow, H. Leon Bradlow
  • Biologically active agent having anti-hypertensive activity in mammals
    Patent number: 5028438
    Abstract: A biologically active agent extracted from female breast cyst fluids displays anti-hypertensive activity in mammals. The agent is also useful in the treatment of congestive heart disease, atrial fibrillation and idiopathic edema in mammals.
    Type: Grant
    Filed: December 9, 1987
    Date of Patent: July 2, 1991
    Assignee: Long Island Jewish Medical Center
    Inventors: Fred I. Chaslow, H. Leon Bradlow
  • Treatment of Prader-Willi syndrome
    Patent number: 5006517
    Abstract: Prader-Willi Syndrome is alleviated by administering of a 3-oxo or hydroxy substituted 5-beta-androstan-17-one to an individual having the syndrome.
    Type: Grant
    Filed: July 24, 1989
    Date of Patent: April 9, 1991
    Assignees: Progenics, Inc., Long Island Jewish Medical Center
    Inventors: Leon Bradlow, Fred I. Chasalow
  • Compositions that affect suppression of cutaneous delayed hypersensitivity and products including same
    Patent number: 4897260
    Abstract: Glucocorticoid carboxylic acid esters and topical compositions thereof are utilized in methods for modulating cutaneous delayed hypersensitivity. Formulations of the glucocorticoid carboxylic acid esters are disclosed including incorporation into percutaneous drug delivery devices.
    Type: Grant
    Filed: February 29, 1988
    Date of Patent: January 30, 1990
    Assignee: The Rockefeller University
    Inventors: Peter M. Ross, H. Leon Bradlow
  • Increasing the bioavailability of alpha-etiocholanolone
    Patent number: 4871726
    Abstract: Methods and compositions are disclosed for inducing an incresed blood level of alpha-etiocholanolone in the body of a mammal in need of such treatments comprising administering to said mammal an amount of etiocholanedione effective to induce said increased blood level.
    Type: Grant
    Filed: July 28, 1987
    Date of Patent: October 3, 1989
    Assignee: Progenics, Inc.
    Inventors: Norman Applezweig, H. Leon Bradlow
  • Breast cyst fluid screening method for cancer risk assessment
    Patent number: 4695471
    Abstract: A method for screening breast cyst fluid to identify patients having a high risk of developing breast cancer, comprising the steps of measuring the chloride ion content of breast cyst fluid aspirated from the patient; and correlating the chloride ion concentration with the risk of developing breast cancer.
    Type: Grant
    Filed: July 30, 1984
    Date of Patent: September 22, 1987
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Martin Fleisher, H. Leon Bradlow, Morton K. Schwartz