Abstract: This disclosure is directed to a method and device for manipulating a sample, such as a biological sample. A device of this disclosure includes mat having a top planar surface spaced apart from a bottom planar surface and a recess formed in the top planar surface extending toward the bottom planar surface, the recess having an opening at the top planar surface and bounded by a non-planar bottom wall. By way of example, a device of this disclosure may be used to embed an aggregate of cells, such as an embryoid body or a neuralized embryoid body, within extracellular matrix.

Abstract: This disclosure is directed to a method and device for manipulating a sample, such as a biological sample. A device of this disclosure includes mat having a top planar surface spaced apart from a bottom planar surface and a recess formed in the top planar surface extending toward the bottom planar surface, the recess having an opening at the top planar surface and bounded by a non-planar bottom wall. By way of example, a device of this disclosure may be used to embed an aggregate of cells, such as an embryoid body or a neuralized embryoid body, within extracellular matrix.

Abstract: This disclosure is directed to a device for manipulating a sample, such as a biological sample. A device of this disclosure includes mat having a top planar surface spaced apart from a bottom planar surface and a recess formedap in the top planar surface extending toward the bottom planar surface, the recess having an opening at the top planar surface and bounded by a non-planar bottom wall. By way of example, a device of this disclosure may be used to embed an aggregate of cells, such as an embryoid body or a neuralized embryoid body, within extracellular matrix.