Patents by Inventor Leon E. Chen

Leon E. Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptides for activation and inhibition of ?PKC
    Patent number: 8822636
    Abstract: Peptides able to inhibit or activate the translocation or function of ?PKC are identified. Administration of the peptides for protection or enhancement of cell damage due to ischemia is described. Therapeutic methods to reduce damage to cells or to enhance damage to cells due to ischemia are also described, as well as methods for screening test compounds for ?PKC-selective agonists and antagonists.
    Type: Grant
    Filed: November 30, 2010
    Date of Patent: September 2, 2014
    Assignee: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Daria Mochly-Rosen, Leon E. Chen
  • Peptides for Activation and Inhibition of Delta-PKC
    Publication number: 20110143991
    Abstract: Peptides able to inhibit or activate the translocation or function of ?PKC are identified. Administration of the peptides for protection or enhancement of cell damage due to ischemia is described. Therapeutic methods to reduce damage to cells or to enhance damage to cells due to ischemia are also described, as well as methods for screening test compounds for ?PKC-selective agonists and antagonists.
    Type: Application
    Filed: November 30, 2010
    Publication date: June 16, 2011
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Daria Mochly-Rosen, Leon E. Chen
  • PROTEIN KINASE C PEPTIDE MODULATORS OF ANGIOGENESIS
    Publication number: 20110098224
    Abstract: The present invention provides peptides for inhibiting various protein kinase C isozymes. The peptide can be directed to any region of the protein kinase C isozyme, and in one embodiment, is directed to the V5 domain. The peptide can be conjugated to a carrier, in a releasable or non-releasable manner. The peptides can be used to inhibit angiogenesis and/or vascular permeability. The peptides can be used to treat subjects having, for example, cancer, diabetic blindness, macular degeneration, rheumatoid arthritis, or psoriasis.
    Type: Application
    Filed: October 12, 2010
    Publication date: April 28, 2011
    Inventors: Leon E. Chen, Derek MaClean, Sarah Walter
  • Method for reducing central nervous system tissue or cell damage in a subject due to stroke
    Patent number: 7915219
    Abstract: Peptides able to inhibit or activate the translocation or function of ?PKC are identified. Administration of the peptides for protection or enhancement of cell damage due to ischemia is described. Therapeutic methods to reduce damage to cells or to enhance damage to cells due to ischemia are also described, as well as methods for screening test compounds for ?PKC-selective agonists and antagonists.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: March 29, 2011
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Daria Mochly-Rosen, Leon E. Chen
  • Peptides for activation and inhibition of ?PKC
    Patent number: 7851586
    Abstract: Peptides able to inhibit or activate the translocation or function of ?PKC are identified. Administration of the peptides for protection or enhancement of cell damage due to ischemia is described. Therapeutic methods to reduce damage to cells or to enhance damage to cells due to ischemia are also described, as well as methods for screening test compounds for ?PKC-selective agonists and antagonists.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: December 14, 2010
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Daria Mochly-Rosen, Leon E. Chen
  • Peptides for activation and inhibition of ?PKC
    Patent number: 7745388
    Abstract: Peptides able to inhibit or activate the translocation or function of ?PKC are identified. Administration of the peptides for protection or enhancement of cell damage due to ischemia is described. Therapeutic methods to reduce damage to cells or to enhance damage to cells due to ischemia are also described, as well as methods for screening test compounds for ?PKC-selective agonists and antagonists.
    Type: Grant
    Filed: May 12, 2004
    Date of Patent: June 29, 2010
    Assignees: National Institute of Health (NIH), The United States of America as represented by the Department of Health and Human Services, The United States of America as represented by NIH Division of Extramural Inventions and Technology Resources (DEITR)
    Inventors: Daria Mochly-Rosen, Leon E. Chen
  • METHOD OF TREATING ACUTE ST-ELEVATION MYOCARDIAL INFARCTION WITH A DELTA PKC ANTAGONIST
    Publication number: 20090318351
    Abstract: Compositions, kits and methods are provided for preventing or treating tissue injury caused by stresses or shocks related to oxygen deficiency, such as ischemia, anoxia, hypoxia, reperfusion and other environmental stresses. In particular, protein kinase C (PKC) isozyme-specific agonists and antagonists are provided for treating cardiac tissue damage due to ischemia-reperfusion, such as acute myocardial infarction.
    Type: Application
    Filed: March 12, 2009
    Publication date: December 24, 2009
    Inventors: Kevin Grimes, Leon E. Chen
  • Peptides for activation and inhibition of deltaPKC
    Publication number: 20090192089
    Abstract: Peptides able to inhibit or activate the translocation or function of ?PKC are identified. Administration of the peptides for protection or enhancement of cell damage due to ischemia is described. Therapeutic methods to reduce damage to cells or to enhance damage to cells due to ischemia are also described, as well as methods for screening test compounds for ?PKC-selective agonists and antagonists.
    Type: Application
    Filed: April 30, 2007
    Publication date: July 30, 2009
    Inventors: Daria Mochly-Rosen, Leon E. Chen
  • PEPTIDES FOR ACTIVATION AND INHIBITION OF DELTAPKC
    Publication number: 20090075901
    Abstract: Peptides able to inhibit or activate the translocation or function of ?PKC are identified. Administration of the peptides for protection or enhancement of cell damage due to ischemia is described. Therapeutic methods to reduce damage to cells or to enhance damage to cells due to ischemia are also described, as well as methods for screening test compounds for ?PKC-selective agonists and antagonists.
    Type: Application
    Filed: August 14, 2007
    Publication date: March 19, 2009
    Inventors: Daria MOCHLY-ROSEN, Leon E. Chen
  • Peptides for activation and inhibition of ?PKC
    Patent number: 6855693
    Abstract: Peptides able to inhibit or activate the translocation or function of ?PKC are identified. Administration of the peptides for protection or enhancement of cell damage due to ischemia is described. Therapeutic methods to reduce damage to cells or to enhance damage to cells due to ischemia are also described, as well as methods for screening test compounds for ?PKC-selective agonists and antagonists.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: February 15, 2005
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Daria Mochly-Rosen, Leon E. Chen
  • Peptides for activation and inhibition of deltaPKC
    Publication number: 20040204364
    Abstract: Peptides able to inhibit or activate the translocation or function of &dgr;PKC are identified. Administration of the peptides for protection or enhancement of cell damage due to ischemia is described. Therapeutic methods to reduce damage to cells or to enhance damage to cells due to ischemia are also described, as well as methods for screening test compounds for &dgr;PKC-selective agonists and antagonists.
    Type: Application
    Filed: May 12, 2004
    Publication date: October 14, 2004
    Inventors: Daria Mochly-Rosen, Leon E. Chen
  • Peptides for activation and inhibition of deltaPKC
    Publication number: 20020150984
    Abstract: Peptides able to inhibit or activate the translocation or function of &dgr;PKC are identified. Administration of the peptides for protection or enhancement of cell damage due to ischemia is described. Therapeutic methods to reduce damage to cells or to enhance damage to cells due to ischemia are also described, as well as methods for screening test compounds for &dgr;PKC-selective agonists and antagonists.
    Type: Application
    Filed: November 9, 2001
    Publication date: October 17, 2002
    Inventors: Daria Mochly-Rosen, Leon E. Chen