Patents by Inventor Leon I. Goldberg

Leon I. Goldberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for reducing emesis and nausea induced by the administration of an emesis causing agent
    Patent number: 5102887
    Abstract: A method for preventing or relieving nausea and emesis associated with the use of an emesis-causing agent in warm-blooded animals comprises administering to the animal both a narcotic analgesic and a quaternary derivative of noroxymorphone prior to, simultaneously with of after administering the emesis-causing agent. A particularly preferred noroxymorphone derivative is methylnaltrexone. The method is highly effective in preventing or relieving nausea and emesis induced by anticancer drugs, and by apomorphine.
    Type: Grant
    Filed: June 15, 1990
    Date of Patent: April 7, 1992
    Assignee: Arch Development Corporation
    Inventor: Leon I. Goldberg
  • Quaternary derivatives of noroxymorphone which relieve nausea and emesis
    Patent number: 4861781
    Abstract: Quaternary derivatives of noroxymorphone are used to prevent or relieve nausea and emesis associated with the use of narcotic analgesics without interfering with the analgesic activity of the drugs. A particularly preferred compound is methylnaltrexone. The compound is administered in a concentration between 0.05 mg/kg and 1.0 mg/kg prior to or concurrently with the administration of the narcotic analgesic.
    Type: Grant
    Filed: September 3, 1987
    Date of Patent: August 29, 1989
    Assignee: The University of Chicago
    Inventor: Leon I. Goldberg
  • Quaternary derivatives of noroxymorphone which relieve nausea and emesis
    Patent number: 4719215
    Abstract: Quaternary derivatives of noroxymorphone are used to prevent or relieve nausea and emesis associated with the use of narcotic analgesics without interfering with the analgesic activity of the drugs. A particularly preferred compound is methylnaltrexone. The compound is administered in a concentration between 0.25 mg/kg and 1.0 mg/kg prior to or concurrently with the administration of the narcotic analgesic.
    Type: Grant
    Filed: March 7, 1986
    Date of Patent: January 12, 1988
    Assignee: University of Chicago
    Inventor: Leon I. Goldberg
  • Epinine and the therapeutic use thereof
    Patent number: 4628064
    Abstract: Pharmaceutical compositions which contain epinine or a pharmaceutically acceptable salt thereof, and allow to reach a release of epinine comprised between 0.5 and 5 .mu.g/Kg/minute.Said compositions are useful in treating congestive heart failures; they stimulate the heart contractility, show a vasodilating and bronchodilating activity as well as a vasodilating activity on specific districts and particularly on the renal district without causing vasoconstrictive and pressor effects.
    Type: Grant
    Filed: July 17, 1984
    Date of Patent: December 9, 1986
    Assignee: SIMES, Societa Italiana Medicinali e Sintetici S.p.A.
    Inventors: Cesare Casagrande, Paolo Ghirardi, Leon I. Goldberg, Germano Marchetti
  • Method of increasing renal blood flow with dopamine derivatives
    Patent number: 4219568
    Abstract: Certain N,N-dialkyl substituted derivatives of dopamine (DA) increase renal blood flow without affecting cardiac contractility. Particularly effective are N,N-di-n-propyl DA; N-n-propyl-N-n-butyl DA; N-n-propyl-N-n-pentyl DA; N-n-propyl-N-isobutyl DA; and N-n-propyl-N-phenethyl DA. Orally effective versions of these derivatives are obtained by acylating the hydroxyl functions.
    Type: Grant
    Filed: March 1, 1978
    Date of Patent: August 26, 1980
    Assignee: University Patents, Inc.
    Inventors: Leon I. Goldberg, Joseph G. Cannon, John P. Long
  • Quaternary derivatives of noroxymorphone which relieve intestinal immobility
    Patent number: 4176186
    Abstract: Compounds of the formula ##STR1## wherein R is allyl or a related radical such as chloroallyl, cyclopropyl-methyl or propargyl, andX is the anion of an acid, especially a chloride, bromide, iodide or methylsulfate anion;the compounds prevent or relieve the intestinal mobility inhibiting side-effects of narcotic analgesics without interfering with the analgesic activity of the latter.
    Type: Grant
    Filed: July 28, 1978
    Date of Patent: November 27, 1979
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Leon I. Goldberg, Herbert Merz, Klaus Stockhaus