Patents by Inventor Leon J. Nesti

Leon J. Nesti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regenerative tissue grafts and methods of making same
    Patent number: 10507187
    Abstract: A graft containing a scaffold that includes a matrix in which are positioned mesenchymal progenitor cells (MPCs) has the capacity to substantially improve wound healing, including wounds resulting from injury to nerve, bone and vascular tissue. MPCs can be harvested from debrided muscle tissue following orthopaedic trauma. The traumatized muscle-derived progenitor cells are a readily available autologous cell source that can be utilized to effect or improve wound healing in a variety of therapeutic settings and vehicles.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: December 17, 2019
    Assignees: THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC., THE UNITED STATES GOVERNMENT, AS REPRESENTED BY THE SECRETARY OF THE ARMY, U.S.A., THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Wesley M. Jackson, Leon J. Nesti, Rocky S. Tuan
  • CELL-NANOFIBER COMPOSITE AND CELL-NANOFIBER-HYDROGEL COMPOSITE AMALGAM BASED ENGINEERED INTERVERTEBRAL DISC
    Publication number: 20160106548
    Abstract: The instant invention is directed to a tissue engineered intervertebral disc comprising at least one inner layer and an exterior layer, wherein: the exterior layer comprises a nanofibrous polymer support comprising one or more polymer nanofibers; the at least one inner layer comprises a hydrogel composition comprising at least one or more hydrogel materials and/or one or more polymer nanofibers; and a plurality of cells which are dispersed throughout the tissue engineered intervertebral disc. Additionally, the instant invention is directed to methods of making such intervertebral discs and methods of treating intervertebral disc damage.
    Type: Application
    Filed: December 28, 2015
    Publication date: April 21, 2016
    Inventors: Wan-Ju Li, Leon J. Nesti, Rocky S. Tuan
  • REGENERATIVE TISSUE GRAFTS AND METHODS OF MAKING SAME
    Publication number: 20140227339
    Abstract: A graft containing a scaffold that includes a matrix in which are positioned mesenchymal progenitor cells (MPCs) has the capacity to substantially improve wound healing, including wounds resulting from injury to nerve, bone and vascular tissue. MPCs can be harvested from debrided muscle tissue following orthopaedic trauma. The traumatized muscle-derived progenitor cells are a readily available autologous cell source that can be utilized to effect or improve wound healing in a variety of therapeutic settings and vehicles.
    Type: Application
    Filed: February 12, 2014
    Publication date: August 14, 2014
    Applicants: THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC., THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF, THE UNITED STATES GOVERNMENT, AS REPRESENTED BY THE SECRETARY OF THE ARMY, U.S.A.
    Inventors: Wesley M. Jackson, Leon J. Nesti, Rocky S. Tuan
  • Tissue graft with non-aligned fiber matrix retains mesenchymal progenitor cells on the non-injury-facing side
    Patent number: 8652458
    Abstract: A graft containing a scaffold that includes a matrix in which are positioned mesenchymal progenitor cells (MPCs) has the capacity to substantially improve wound healing, including wounds resulting from injury to nerve, bone and vascular tissue. MPCs can be harvested from debrided muscle tissue following orthopaedic trauma. The traumatized muscle-derived progenitor cells are a readily available autologous cell source that can be utilized to effect or improve wound healing in a variety of therapeutic settings and vehicles.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: February 18, 2014
    Assignees: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., The United States of America, as represented by the Secretary of the Army, U.S.A., The United States of America, as represented by the Secretary of the Department of Health and Human Services
    Inventors: Wesley M. Jackson, Leon J. Nesti, Rocky S. Tuan
  • REGENERATIVE TISSUE GRAFTS AND METHODS OF MAKING SAME
    Publication number: 20110318414
    Abstract: A graft containing a scaffold that includes a matrix in which are positioned mesenchymal progenitor cells (MPCs) has the capacity to substantially improve wound healing, including wounds resulting from injury to nerve, bone and vascular tissue. MPCs can be harvested from debrided muscle tissue following orthopaedic trauma. The traumatized muscle-derived progenitor cells are a readily available autologous cell source that can be utilized to effect or improve wound healing in a variety of therapeutic settings and vehicles.
    Type: Application
    Filed: August 5, 2009
    Publication date: December 29, 2011
    Inventors: Wesley M. Jackson, Leon J. Nesti, Rocky S. Tuan
  • CELL-NANOFIBER COMPOSITE AND CELL-NANOFIBER-HYDROGEL COMPOSITE AMALGAM BASED ENGINEERED INTERVERTEBRAL DISC
    Publication number: 20100179659
    Abstract: The instant invention is directed to a tissue engineered intervertebral disc comprising at least one inner layer and an exterior layer, wherein: the exterior layer comprises a nanofibrous polymer support comprising one or more polymer nanofibers; the at least one inner layer comprises a hydrogel composition comprising at least one or more hydrogel materials and/or one or more polymer nanofibers; and a plurality of cells which are dispersed throughout the tissue engineered intervertebral disc. Additionally, the instant invention is directed to methods of making such intervertebral discs and methods of treating intervertebral disc damage.
    Type: Application
    Filed: September 27, 2007
    Publication date: July 15, 2010
    Inventors: Wan-Ju Li, Leon J. Nesti, Rocky S. Tuan