Patents by Inventor Leon J.R.M. Raeven

Leon J.R.M. Raeven has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biochemical synthesis of 1,4-butanediamine
    Patent number: 8497098
    Abstract: The invention relates to a process for biochemical synthesis of 1,4-butanediamine in a microorganism having an increased level of an ornithine decarboxylase activity (increased ODC activity) as compared to the native level of the ornithine decarboxylase activity, wherein in the microorganism also an increased activity of N-acetylglutamate formation is present as compared to the native level of activity of N-acetylglutamate formation in the microorganism and wherein 1,4-butanediamine produced in the microorganism is excreted into a fermentation broth, and is recovered from the fermentation broth. The invention also relates to vectors, plasmids and hosts carrying a corresponding increased ODC activity and an increased activity of N-acetylglutamate formation.
    Type: Grant
    Filed: July 11, 2005
    Date of Patent: July 30, 2013
    Assignee: DSM IP Assets B.V.
    Inventors: Katrin Eppelmann, Petrus M. M. Nossin, Leon J. R. M. Raeven, Susanne M. Kremer, Marcel G. Wubbolts
  • Biochemical Synthesis of 1,4-Butanediamine
    Publication number: 20090011478
    Abstract: The invention relates to a process for biochemical synthesis of 1,4-butanediamine in a microorganism having an increased level of an ornithine decarboxylase activity (increased ODC activity) as compared to the native level of the ornithine decarboxylase activity, wherein in the microorganism also an increased activity of N-acetylglutamate formation is present as compared to the native level of activity of N-acetylglutamate formation in the microorganism and wherein 1,4-butanediamine produced in the microorganism is excreted into a fermentation broth, and is recovered from the fermentation broth. The invention also relates to vectors, plasmids and hosts carrying a corresponding increased ODC activity and an increased activity of N-acetylglutamate formation.
    Type: Application
    Filed: July 11, 2005
    Publication date: January 8, 2009
    Applicant: DSM IP ASSETS B.V.
    Inventors: Katrin Eppelmann, Petrus M.M. Nossin, Leon J.R.M. Raeven, Susanne M. Kremer, Marcel G. Wubbolts