Abstract: PCT A medical device (10) for insertion into a bodily vessel (4) to treat an aneurysm (5) having an aneurysm neck, the device (10) comprising: a mechanically expandable device expandable from a first position to a second position; the mechanically expandable device having an exterior circumferential surface at end portions (11, 12) of the mechanically expandable device such that the exterior circumferential surface engages with the inner surface of the vessel (4) so as to maintain a fluid pathway through said vessel (4) when the end portions (11, 12) of the mechanically expandable device are expanded radially outwardly to the second position; the mechanically expandable device having an exterior non-circumferential surface at a connecting portion (13) of the mechanically expandable device to connect the end portions (11, 12); and an expandable membrane (15) extending over a portion of the exterior non-circumferential surface, the membrane (15) is expanded in response to expansion of the mechanically expandabl

Abstract: An endovascular device (10) for insertion into a bodily vessel (5) to treat a diseased, damaged or weakened portion of a vessel wall (50), the endovascular device (10) comprising: a mechanically expandable device (11) expandable from a first position to a second position, said mechanically expandable device (11) is expanded radially outwardly to the second position such that the circumferential surface of said mechanically expandable device (11) engages with the inner surface of the vessel (5) so as to maintain a fluid pathway through said vessel (5); and a membrane (20) covering at least a portion of the circumferential surface of said mechanically expandable device (11), the membrane (20) comprising a plurality of pores (25), the porosity of the membrane (20) being defined by the ratio of the material surface area of the membrane (20) determined by the size of the pores (21) and the distance between adjacent pores (22, 23); wherein the mechanically expandable device (10) is positioned in the bodily vessel (

Abstract: An occluding device including expandable scaffold and a flow-limiting member is described. In some embodiments the scaffold is an expandable or self-expanding stent deliverable over a guide wire. The flow-limiting member can include a valve that can be closed following deployment. On deployment the stent and flow-limiting member can engage an inner surface of a body cavity lumen, blocking flow of material. In some embodiments the body cavity is a blood vessel, and the device can be used to block blood flow. In some embodiments the device includes bioactive agents.

Abstract: Embodiments of a uniformly porous membrane covering an endoprosthetic device, for example, a stent used to treat an aneurysm, are described. Some embodiments have a pore size and spacing that provides a material ratio of between 70-80% in the deployed state. Material ratio is the proportion of the total porous segment of the membrane that corresponds to membrane material, the remainder being pores. In some embodiments, pore size ranges from about 10-100 ?m. In some embodiments, pores are equidistantly spaced with pore spacing in a range of about 40-100 ?m. The combination of pore size and spacing are effective to provide a membrane that substantially prevents flow to the aneurysm, while maintaining flow to perforator vessels. In some embodiments the membrane includes permanently attached agents that promote attachment of endothelial cells or progenitors and healing of the aneurysm, or reduce immune responses detrimental to the healing process.

Abstract: An endovascular device (10) for treatment of a bodily vessel (5) of a patient at a surgical site, the endovascular device (10) comprising: a mechanically expandable device (11) expandable from a first position to a second position, said mechanically expandable device (11) is expanded radially outwardly to the second position such that the circumferential surface of said mechanically expandable device (11) engages with the inner surface of the vessel (5) so as to maintain a fluid pathway through said vessel (5); and a membrane (15) secured to a portion of the circumferential surface of said mechanically expandable device (11); wherein at least one capture agent (20, 21) is permanently attached to the lumenal surface of the membrane (15) to capture a predetermined target component from blood passing through the fluid pathway; and at least one signal agent (22) is permanently attached to the lumenal surface of the membrane (15) to signal the captured target component to up regulate or down regulate a cell functi

Abstract: A method for treating a bifurcation aneurysm, the aneurysm having an aneurysm neck, by positioning a first mechanically expandable device in a first bifurcation branch proximate to the aneurysm neck; positioning a second mechanically expandable device in a second bifurcation branch proximate to the aneurysm neck; and expanding the mechanically expandable devices to constrict the aneurysm neck such that blood circulation to the bifurcation aneurysm is reduced.

Abstract: A medical device (10) for insertion into a bodily vessel (6) to treat an aneurysm (5) having an aneurysm neck, the device (10) comprising: a mechanically expandable device (20) expandable from a first position to a second position, said mechanically expandable device (20) is expanded radially outwardly to the second position such that the exterior surface of said mechanically expandable device (20) engages with the inner surface of the vessel (6) so as to maintain a fluid pathway through said vessel (6); a therapeutically effective amount of a chemical compound comprising a biosynthesis accelerator to stimulate cell growth; and a polymer (30, 41, 42) mixed with the chemical compound to manage the release rate of the chemical compound; wherein the mechanically expandable device (20) provides a support for the release of the chemical compound within the aneurysm (5) to stimulate cell growth within the aneurysm (5) and close the aneurysm neck.

Abstract: A method for treating a bifurcation or trifurcation aneurysm (201) occurring on a first artery, the first artery and a second artery joining to a third artery, the method comprising: inserting a medical device (202) such that it is at least partially located in the first artery and is at least partially located in the third artery; expanding the medical device (202) from a first position to a second position, said medical device (202) is expanded radially outwardly to the second position such that the exterior surface of said medical device (202) engages with the inner surface of the first and third arteries so as to maintain a fluid pathway through said arteries; and positioning the medical device (202) such that a membrane (203) of the medical device (202) is located against an aneurysm neck of the aneurysm (201) to obstruct blood circulation to the aneurysm (201) when the medical device (202) is expanded to the second position, and at least a portion of the membrane (203) is secured to the medical device (

Abstract: A medical device for insertion into a bodily vessel to treat an aneurysm (201), the device comprising: a mechanically expandable device (202) expandable from a first position to a second position, said mechanically expandable device (202) is expanded radially outwardly to the second position such that the exterior surface of said mechanically expandable (202) engages with the inner surface of the vessel so as to maintain a fluid pathway through said vessel; and a membrane (203) expandable from a first position to a second position in response to expansion of said mechanically expandable device (202), said membrane (203) obstructing blood circulation to the aneurysm (201) when expanded to the second position, and at least a portion of the membrane (203) is secured to the mechanically expandable device (202) to maintain the position of the membrane (203) relative to the mechanically expandable device (202) when expanded to the second position.

Abstract: An implantable mechanical device for insertion into a passage, where the device is made from a platinum alloy selected from the group consisting of platinum:iridium alloy, platinum:tungsten alloy, platinum:rhodium:ruthenium alloy, platinum:rhodium alloy and platinum:nickel alloy.

Abstract: A composite expandable stent for delivery into a vessel carrying blood comprising an expandable support frame having first and second end portions. A porous imprevious polymer sleeve having inner and outer surfaces extending over the support frame. A coating is disposed on at least one of the inner and outer surfaces of the polymer sleeve for enhancing endothelial cell growth on the device and polymer sleeve. The stent can be cylindrical or tapered.