Patents by Inventor Leon Tertoolen

Leon Tertoolen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cardiomyocyte maturation
    Patent number: 10844354
    Abstract: This disclosure generally concerns the fields of cell biology and molecular biology. In particular the invention concerns the field of stem cell biology and maturation of stem cell-derived cardiomyocytes. Disclosed is a method for improving the maturity of stem-cell derived cardiomyocytes, in particular of the ventricular type, as can be witnessed by, for example, an improved upstroke velocity of the stem-cell derived cardiomyocytes.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: November 24, 2020
    Assignee: NCARDIA B.V.
    Inventors: Stefan Robbert Braam, Leon Tertoolen, Christine Mummery
  • Differentiation of human embryonic stem cells to cardiomyocytes
    Publication number: 20070161107
    Abstract: A method for inducing cardiomyocyte differentiation of a hES cell, the method comprising co-culturing the hES cell with a cell excreting at least one cardiomyocyte differentiation inducing factor or with an extracellular medium therefrom, under conditions that induce differentiation, cells and cell populations so produced, and uses of the cells.
    Type: Application
    Filed: March 11, 2004
    Publication date: July 12, 2007
    Inventors: Christine Mummery, Petrus Adrianus Doevendans, Leon Tertoolen