Abstract: The invention relates to a drive device for a printing press (100), especially a shaftless printing machine by intaglio engraving, which comprises a plurality of individually driven printing groups (111 to 114) provided with linear register adjusting devices. The first printing group is provided with means for simultaneously adjusting the linear register adjusting devices of all printing groups (111; 111, 112; 111, 112, 113) mounted upstream of a first printing group (112; 113; 114) or with means for simultaneously adjusting the linear register adjusting devices of the first printing group (112; 113) and of all printing groups (113, 114; 114) mounted downstream of the first printing group (112; 113) in order to adjust a register variation (?R2, ?R3, ?R4) on the first printing group. The invention also relates to a method for adjusting a misalignment (?R2, ?R3, ?R4).