Patents by Inventor Leona C. Fitzmaurice

Leona C. Fitzmaurice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5850025
    Abstract: Transgenic plants that express properly processed ruminant or ruminant-like lysozymes and that are resistant to bacterial pathogens, including both gram-negative and gram-positive bacteria, are provided. A preferred embodiment provides transgenic tobacco plants that express a sufficient concentration of properly processed bovine lysozyme c2 to render the plants less susceptible to bacterial plant pathogens.Methods and compositions for treatment of plants, seeds and other plant tissues prior to or after exposure or infection with bacterial plant pathogens are also provided. In particular, compositions and methods of contacting plants with such compositions that contain a concentration of bovine lysozyme c2 or other ruminant or ruminant-like lysozyme are provided.A signal sequence that is effective for properly processing heterologous proteins that are expressed in transgenic plants is also provided.
    Type: Grant
    Filed: April 22, 1997
    Date of Patent: December 15, 1998
    Assignee: Sibia Neurosciences, Inc.
    Inventors: Theodore Erik Mirkov, Leona C. Fitzmaurice
  • Patent number: 5665579
    Abstract: Transgenic plants that are modified to produce fruits that have altered levels of soluble solids compared to non-transgenic species of the same species are provided. The transgenic plants are modified by introduction of DNA constructs that encode invertase operatively linked to DNA encoding regulatory regions that direct transcription of the DNA encoding invertase and to DNA encoding sequences that direct proper processing of the invertase through the secretory pathways of the plant and targeting of the invertase to the vacuole.In particular, DNA constructs encoding tomato plant vacuolar invertase in operative linkage with a developmentally regulated promoter region are provided. Preferred regulatory and structural DNA is obtained from genomic DNA clones and cDNA clones encoding tomato fruit vacuolar invertases from the commercial tomato plant, Lycopersicon esculentum, and wild tomato plant, Lycopersicon pimpinellifolium.
    Type: Grant
    Filed: May 17, 1994
    Date of Patent: September 9, 1997
    Assignee: The Salk Institute Biotechnology/Industrial Associates, Inc.
    Inventors: Leona C. Fitzmaurice, T. Erik Mirkov, Kathryn J. Elliott, William Owen Butler, Yoshihiro Konno, Craig Duane Dickinson
  • Patent number: 5576428
    Abstract: Transgenic plants that are modified to produce fruits that have altered levels of soluble solids compared to non-transgenic plants of the same species are provided. The transgenic plants are prepared by introducing into plants DNA constructs that encode invertase operatively linked to DNA encoding regulatory regions that direct transcription of the DNA encoding invertase and operatively linked to DNA encoding amino acids that direct proper processing of the invertase through the secretory pathways of the plant and targeting of the invertase to the vacuole.In particular, DNA constructs encoding tomato plant vacuolar invertase in operative linkage with a developmentally regulated promoter region are provided. Preferred regulatory and structural DNA is obtained from genomic DNA clones and cDNA clones encoding tomato fruit vacuolar invertases from the commercial tomato plant, Lycopersicon esculentum, and wild tomato plant, Lycopersicon pimpinellifolium.
    Type: Grant
    Filed: August 20, 1993
    Date of Patent: November 19, 1996
    Assignee: The Salk Institute Biotechnology/Industrial Associates, Inc.
    Inventors: William O. Butler, Yoshihiro Konno, Craig D. Dickinson, Leona C. Fitzmaurice, Theodore E. Mirkov, Kathryn J. Elliott
  • Patent number: 5422108
    Abstract: Transgenic plants that express properly processed ruminant or ruminant-like lysozymes and that are resistant to bacterial pathogens, including both gram-negative and gram-positive bacteria, are provided. A preferred embodiment provides transgenic tobacco plants that express a sufficient concentration of properly processed bovine lysozyme c2 to render the plants less susceptible to bacterial plant pathogens.Methods and compositions for treatment of plants, seeds and other plant tissues prior to or after exposure or infection with bacterial plant pathogens are also provided. In particular, compositions and methods of contacting plants with such compositions that contain a concentration of bovine lysozyme c2 or other ruminant or ruminant-like lysozyme are provided.A signal sequence that is effective for properly processing heterologous proteins that are expressed in transgenic plants is also provided.
    Type: Grant
    Filed: November 25, 1991
    Date of Patent: June 6, 1995
    Assignee: Smart Plants International Inc.
    Inventors: T. Erik Mirkov, Leona C. Fitzmaurice