Patents by Inventor Leona Ling

Leona Ling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR PREDICTING RESPONSE TO TREATMENT
    Publication number: 20230221302
    Abstract: Described herein are methods for treating rheumatoid arthritis by determining whether a subject having rheumatoid arthritis will respond to an anti-TNF-alpha therapy based on the number of innate and adaptive immune cells in a sample from the subject prior to treatment.
    Type: Application
    Filed: March 21, 2023
    Publication date: July 13, 2023
    Inventors: Ishan Capila, Victor Farutin, Thomas Prod'homme, Kevin McConnell, Leona Ling
  • Methods for predicting response to treatment
    Patent number: 11639923
    Abstract: Described herein are methods for treating rheumatoid arthritis by determining whether a subject having rheumatoid arthritis will respond to an anti-TNF-alpha therapy based on the number of innate and adaptive immune cells in a sample from the subject prior to treatment.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: May 2, 2023
    Assignee: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Ishan Capila, Victor Farutin, Thomas Prod'homme, Kevin McConnell, Leona Ling
  • FCRN ANTIBODIES AND METHODS OF USE THEREOF
    Publication number: 20220144946
    Abstract: Methods for dosing of antibodies to human neonatal Fc receptor (FcRn) are described. The anti-FcRn antibodies are useful, e.g., to promote clearance of autoantibodies in a subject, to suppress antigen presentation in a subject, to block an immune response, e.g., block an immune complex-based activation of the immune response in a subject, or to treat immunological diseases (e.g., autoimmune diseases) in a subject.
    Type: Application
    Filed: November 5, 2021
    Publication date: May 12, 2022
    Inventors: Sindhu Ramchandran, Hong Sun, William Denney, Santiago Arroyo, Leona Ling, Jocelyn Leu, Jianhua Jin, Marie-Helene Jouvin, Keith Karcher, Shawn Black, Yaowei Zhu
  • METHODS FOR PREDICTING RESPONSE TO TREATMENT
    Publication number: 20200256851
    Abstract: Described herein are methods for treating rheumatoid arthritis by determining whether a subject having rheumatoid arthritis will respond to an anti-TNF-alpha therapy based on the number of innate and adaptive immune cells in a sample from the subject prior to treatment.
    Type: Application
    Filed: September 18, 2018
    Publication date: August 13, 2020
    Inventors: Ishan Capila, Victor Farutin, Thomas Prod'homme, Kevin McConnell, Leona Ling
  • Pyrazoles and methods of making and using the same
    Publication number: 20060264440
    Abstract: The invention is based on the discovery that compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I (I).
    Type: Application
    Filed: February 12, 2004
    Publication date: November 23, 2006
    Applicant: BIOGEN IDEC MA INC.
    Inventors: Wen-Cherng Lee, Lihong Sun, Feng Shan, Claudio Chuaqui, Mark Cornebise, Timothy Pontz, Mary Carter, Juswinder Singh, Paula Boriack-Sjodin, Leona Ling, Russell Petter
  • Angiogenesis-modulating compositions and uses
    Publication number: 20050054568
    Abstract: Hedgehog agonists and antagonists can be used to regulate angiogenesis, and to prevent angiogenesis driven pathologies. Furthermore, hedgehog agonists and antagonists have utility in modulating tissue repair and in the treatment of many forms of cancer.
    Type: Application
    Filed: August 29, 2003
    Publication date: March 10, 2005
    Inventors: Leona Ling, Michele Sanicola-Nadel, Karen Kotkow, Lee Rubin