Abstract: The present invention relates to the construction, expression, and purification of synthetic or recombinant light chain (LC) botulinum neurotoxin genes from all botulinum neurotoxin serotypes. The methods of the invention can provide 1.1 g of the LC per liter of culture. The LC product is stable and proteolytically active. Methods of using the products of the invention are described.

Abstract: Disclosed is a system and method for creating a financial index related to healthcare costs. A financial derivative instrument can be created from the index. Using the financial derivative instrument, an entity can hedge against unexpected fluctuations of healthcare costs.

Abstract: Aspects relate to a cognitive agent that performs functions associated with a desired result. The functions performed by cognitive agent supplement other activities performed at a same time. In such a manner, the cognitive agent can function as a surrogate for a user. A performed activity can trigger implementation of another activity that is an extension of the performed activity. Cognitive agent can perform functions that can be represented as an avatar. Further, cognitive agent can be associated with a diagnostics component that evaluates an operating condition. Based on the operating condition cognitive agent can implement automatic actions associated with mitigating failures and/or prolonging the life of machinery.

Abstract: Aspects of present invention provide a method, computer-readable medium, and system for saving and modifying a draft voicemail message. More specifically, a caller may create a draft voicemail message that is saved without being transmitted to a callee. Then the caller may access the draft voicemail message and generate events to modify the message. More specifically, when a modification event is generated, event data that describes the modification to the voicemail message requested by the caller is received. Then, the data included with the voicemail message is updated to reflect the input received from the caller.

Abstract: The present invention relates, inter alia, to a process for enriching a hydrocarbon fuel for use in an internal combustion engine, the process comprising: (i) contacting a hydrocarbon fuel with a gas stream containing hydrogen gas such that at least some of the hydrogen gas is introduced into the hydrocarbon fuel to produce an enriched hydrocarbon fuel; and optionally (ii) delivering the enriched hydrocarbon fuel to an internal combustion engine. The present invention further provides a device for use in the process.

Abstract: The present invention comprises a new class of compounds capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula I wherein R1 is and A1, A2, A3, A4, X, Z, Z?, R1, R2, R3, R4, R5 and R6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.

Abstract: Aspects relate to a cognitive agent that performs functions associated with a desired result. The functions performed by cognitive agent supplement other activities performed at a same time. In such a manner, the cognitive agent can function as a surrogate for a user. A performed activity can trigger implementation of another activity that is an extension of the performed activity. Cognitive agent can perform functions that can be represented as an avatar. Further, cognitive agent can be associated with a diagnostics component that evaluates an operating condition. Based on the operating condition cognitive agent can implement automatic actions associated with mitigating failures and/or prolonging the life of machinery.

Abstract: A perforated plate for a vibratory sifter, the perforated plate including a base plate comprising a plurality of openings formed therethrough, and a flange integrally formed with the base plate. A method of forming a screen assembly for a vibratory sifter, the method including forming a base plate, forming a plurality of openings extending from a top surface to a bottom surface of the base plate, and forming an integral flange on the base plate.

Abstract: A perforated plate for a vibratory sifter, the perforated plate including a base plate comprising a plurality of openings formed therethrough, and a flange integrally formed with the base plate. A method of forming a screen assembly for a vibratory sifter, the method including forming a base plate, forming a plurality of openings extending from a top surface to a bottom surface of the base plate, and forming an integral flange on the base plate.

Abstract: A transducer system is disclosed for detecting actual or simulated body sounds. An audio signal generation and detection system is disclosed for the purposes of simulating the medical examination of a patient or simulating the listening of sounds seeming to emanate from a live or inanimate body. A signal generator sets up a voltage potential at an electrode physically attached to the body, or electrically connected to a body, thereby setting up a voltage potential on a surface area of the body. An electric field potential sensor or a capacitive electrical sensor placed in proximity to the electrode or body surface then detects the voltage potential. The signals produced by the signal generator can represent heart, lung, bowel or other sounds and the electrical sensor can take the physical form of a listening device such as a stethoscope, thereby creating a simulation of listening to body sounds for medical diagnostic purposes.

Abstract: Aspects relate to a cognitive agent that performs functions associated with a desired result. The functions performed by cognitive agent supplement other activities performed at a same time. In such a manner, the cognitive agent can function as a surrogate for a user. A performed activity can trigger implementation of another activity that is an extension of the performed activity. Cognitive agent can perform functions that can be represented as an avatar. Further, cognitive agent can be associated with a diagnostics component that evaluates an operating condition. Based on the operating condition cognitive agent can implement automatic actions associated with mitigating failures and/or prolonging the life of machinery.

Abstract: A medical diagnostic and communications apparatus with audio output comprises an electronic processor for processing stethoscope signals and secondary audio signals. An electronic stethoscope sensor is contained within a housing for transducing body sounds to electronic signals, and is operatively connected to the electronic processor. One or more secondary audio signal sources operatively connects to the electronic processor. A common audio output is connected to electronic processor to convert electronic stethoscope signals or secondary audio signals to acoustic output. These sounds may be produced separately or mixed.

Abstract: Aspects relate to a cognitive agent that performs functions associated with a desired result. The functions performed by cognitive agent supplement other activities performed at a same time. In such a manner, the cognitive agent can function as a surrogate for a user. A performed activity can trigger implementation of another activity that is an extension of the performed activity. Cognitive agent can perform functions that can be represented as an avatar. Further, cognitive agent can be associated with a diagnostics component that evaluates an operating condition. Based on the operating condition cognitive agent can implement automatic actions associated with mitigating failures and/or prolonging the life of machinery.

Abstract: The present invention relates to the construction, expression, and purification of synthetic or recombinant light chain (LC) botulinum neurotoxin genes from all botulinum neurotoxin serotypes. The methods of the invention can provide 1.1 g of the LC per liter of culture. The LC product is stable and proteolytically active. Methods of using the products of the invention are described.

Abstract: Provided is a single repository for capturing, connecting, sharing, and visualizing information based on a geographic location, for example. Detailed information can be dynamically rendered as a function of a user parameter, which can include a user demographic, a user profile, and a user preference information. Map information and advertisements displayed in conjunction with the map information can be dynamically rendered as a function of a user advertising preference. If a user prefers one product over another product, a first advertisement for the less preferred product can be replaced with a second advertisement for the preferred product.

Abstract: This invention relates to a method of automatically setting the gain of an echo signal in a Doppler ultrasound haemodynamic monitor. In essence the invention comprises monitoring the strength of velocity components measured by the apparatus, and identifying a group of such components occupying a particular band within the overall velocity spectrum. The signal gain is then adjusted so that the perceived width of the band falls within predetermined limits. The monitoring or assessment of the velocity components is preferably undertaken when the overall flow velocity is high e.g. during systole.

Abstract: The invention provides potent quinolinol-based BoNT/A small-molecule inhibitors of botulinum neurotoxins, in particular of Clostridium botulinum serotype A neurotoxins. The invention also provides methods of using these small-molecule inhibitors to inhibit infections by Clostridium botulinum, as well as, methods of preventing infections by Clostridium botulinum through materials that may be ingested.

Abstract: Combined blood flow and blood pressure measurements are used for the calculation of central vascular blood flow parameters. Blood flow measurements may be made simultaneously with arterial pressure measured either centrally or peripherally and central venous pressure for the monitoring of human subjects. A combined blood flow and blood pressure measurement device for hemodynamic monitoring may include a Doppler ultrasound probe utilizing a continuous wave or pulse wave ultrasound beam for the measurement of blood flow in the aorta, combined with arterial pressure measurement, or signal input from a suitable pressure transducer system from one of either the radial, brachial, dorsalis pedis or femoral artery. The ultrasound probe may comprise either an esophageal or suprasternal ultrasound probe, while the blood pressure measurement may be either an electronic transducer blood pressure sphygmomanometer on the arm, or a finger cot infrared light optical pulse detector.

Abstract: A perforated plate for a vibratory sifter, the perforated plate including a base plate comprising a plurality of openings formed therethrough, and a flange integrally formed with the base plate. A method of forming a screen assembly for a vibratory sifter, the method including forming a base plate, forming a plurality of openings extending from a top surface to a bottom surface of the base plate, and foaming an integral flange on the base plate.

Abstract: Provided is a single repository for capturing, connecting, sharing, and visualizing information based on a geographic location, for example. Detailed information of a structure or object information can be displayed on a rooftop or over an area of interest. The detailed information can be provided for a single structure or for each structure shown on a map area. According to an embodiment is a system that facilitates surface overlay and bounding on a map. The system can include a receiver component that receives information for an object, a boundary component that ascertains a perimeter of the object, and a rendering component that selectively displays the object information and object on a map based in part on a user perspective.